Preprint / Version 1

From Code to Cure The Role of Generative AI in Antibody Design and Immunotherapy Optimization

##article.authors##

  • Ben Wilhelm Tamalpais High School

DOI:

https://doi.org/10.58445/rars.524

Keywords:

Cancer, immunology, Biology, Antibody, Artificial Inteligence, Immunotherapy, Biomedicine

Abstract

This research paper explores the emergent integration of Generative Artificial Intelligence (AI) in the specialized field of immunotherapy, aiming to revolutionize disease treatment and clarify the future role of AI in healthcare. It focuses on the potential of Generative AI, characterized by its autonomous ability to produce diverse and unique outputs, to enhance immunotherapy—a treatment strategy that leverages the body's immune system to fight diseases. Drawing on machine learning's transformative potential, which powers generative models like OpenAI’s GPT-3 and Google’s BERT, we delve into the application of these technologies in immunotherapy, particularly in designing effective antibodies. This possibility introduces opportunities for more targeted and efficient treatment modalities in immunotherapy, promising enhanced therapeutic outcomes. This article delves into the present and prospective uses of generative AI in immunotherapy, championing enhanced design and functionality, with the ambition of nurturing a potent fusion of technology and biology, "From Code to Cure," that could revolutionize medical research and patient care.

References

What is generative AI? (2023, January 19). McKinsey & Company. https://www.mckinsey.com/featured-insights/mckinsey-explainers/what-is-generative-ai

Dobosz, Paula, and Tomasz Dzieciątkowski. “The Intriguing History of Cancer Immunotherapy.” Frontiers in immunology vol. 10 2965. 17 Dec. 2019, doi:10.3389/fimmu.2019.02965 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928196/

Callaway, E. (2023). How generative AI is building better antibodies. Nature. https://www.nature.com/articles/d41586-023-01516-w

Kaul, V., Enslin, S., & Gross, S. A. (2020). History of artificial intelligence in medicine. Gastrointestinal Endoscopy, 92(4), 807–812. https://pubmed.ncbi.nlm.nih.gov/32565184/

History of Artificial Intelligence in Medicine - Gastrointestinal Endoscopy, https://www.giejournal.org/article/S0016-5107(20)34466-7/fulltext

Kulikowski, C. A. (2019). Beginnings of Artificial Intelligence in Medicine (AIM): Computational Artifice Assisting Scientific Inquiry and Clinical Art – with Reflections on Present AIM Challenges. Yearbook of Medical Informatics, 28(01), 249–256. https://pubmed.ncbi.nlm.nih.gov/31022744/

Sardanelli, F., Castiglioni, I., Colarieti, A., Schiaffino, S., & Di Leo, G. (2023). Artificial intelligence (AI) in biomedical research: discussion on authors’ declaration of AI in their articles title. European Radiology Experimental, 7(1). https://eurradiolexp.springeropen.com/articles/10.1186/s41747-022-00316-7

Athanasopoulou, K., Daneva, G. N., Adamopoulos, P. G., & Scorilas, A. (2022). Artificial intelligence: the milestone in modern biomedical research. BioMedInformatics, 2(4), 727–744. https://www.mdpi.com/2673-7426/2/4/49#:~:text=AI%20is%20set%20to%20reduce,and%20personalized%20medicine%20%5B30%5D.

Generative AI – What is it and How Does it Work? | NVIDIA. (n.d.-b). NVIDIA. https://www.nvidia.com/en-us/glossary/data-science/generative-ai/#:~:text=What%20is%20Generative%20AI%3F,or%20other%20types%20of%20data.

Lawton, G. (2023). GANs vs. VAEs: What is the best generative AI approach? Enterprise AI. https://www.techtarget.com/searchenterpriseai/feature/GANs-vs-VAEs-What-is-the-best-generative-AI-approach

Davenport, T. H. (2023, August 15). How generative AI is changing creative work. Harvard Business Review. https://hbr.org/2022/11/how-generative-ai-is-changing-creative-work

Professional, C. C. M. (n.d.). Antibodies. Cleveland Clinic. https://my.clevelandclinic.org/health/body/22971-antibodies#:~:text=Antibodies%20are%20proteins%20that%20protect,word%20for%20antibody%20is%20immunoglobulin.

What is immunotherapy? (2022, May 26). Cancer.Net. https://www.cancer.net/navigating-cancer-care/how-cancer-treated/immunotherapy-and-vaccines/what-immunotherapy#:~:text=Immunotherapy%20is%20a%20type%20of,and%2For%20other%20cancer%20treatments.

Zhang, H., & Chen, J. (2018). Current status and future directions of cancer immunotherapy. Journal of Cancer, 9(10), 1773–1781. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968765/

Callaway, E. (2023b). How generative AI is building better antibodies. Nature. https://www.nature.com/articles/d41586-023-01516-w

Kim, J., McFee, M., Fang, Q., Abdin, O., & Kim, P. M. (2023). Computational and artificial intelligence-based methods for antibody development. Trends in Pharmacological Sciences, 44(3), 175–189. https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(22)00279-6

Zhavoronkov, A., PhD. (2022, December 21). AI In Big Pharma: The First Antibody Designed Using AI In The Clinic. Forbes. https://www.forbes.com/sites/alexzhavoronkov/2022/12/21/ai-in-big-pharma-the-first-antibody-designed-using-ai-in-the-clinic/?sh=5ba8343e769e

Xu, Z., Wang, X., Zeng, S., Ren, X., Yan, Y., & Gong, Z. (2021). Applying artificial intelligence for cancer immunotherapy. Acta Pharmaceutica Sinica B, 11(11), 3393–3405. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642413/

Gao, Q., Yang, L., Lu, M., Jin, R., Ye, H., & Ma, T. (2023). The artificial intelligence and machine learning in lung cancer immunotherapy. Journal of Hematology & Oncology, 16(1). https://jhoonline.biomedcentral.com/articles/10.1186/s13045-023-01456-y

Naik, N., Hameed, B. M. Z., Shetty, D. K., Swain, D., Shah, M., Paul, R., Aggarwal, K., Ibrahim, S., Patil, V., Smriti, K., Shetty, S., Prasad, B., Chlosta, P., & Somani, B. (2022). Legal and ethical consideration in artificial intelligence in healthcare: Who takes responsibility? Frontiers in Surgery, 9. https://www.frontiersin.org/articles/10.3389/fsurg.2022.862322/full

Gerke, S., Minssen, T., & Cohen, G. (2020b). Ethical and legal challenges of artificial intelligence-driven healthcare. In Elsevier eBooks (pp. 295–336). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332220/

References for visuals:

Dobosz, Paula, and Tomasz Dzieciątkowski. “The Intriguing History of Cancer Immunotherapy.” Frontiers in Immunology, vol. 10, Frontiers Media, Dec. 2019, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928196/.

Athanasopoulou, Konstantina, et al. “Artificial Intelligence: The Milestone in Modern Biomedical Research.” BioMedInformatics, vol. 2, no. 4, Dec. 2022, pp. 727–44. https://www.mdpi.com/2673-7426/2/4/49#:~:text=AI%20is%20set%20to%20reduce,and%20personalized%20medicine%20%5B30%5D.

Yang, Ming, et al. “Cancer Immunotherapy and Delivery System: An Update.” Pharmaceutics, vol. 14, no. 8, Multidisciplinary Digital Publishing Institute, Aug. 2022, p. 1630. https://www.mdpi.com/1999-4923/14/8/1630.

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Posted

2023-10-01