A Systematic Review of Fasting Biology
DOI:
https://doi.org/10.58445/rars.897Keywords:
autophagy, fasting, glucose, circadian rhythmAbstract
Fasting is the pattern-based restriction of nutrient consumption or calories regularly practiced for health benefits. Through fasting, the availability of nutrients depletes and multiple biological responses are triggered. Biological processes that have been observed to respond to nutrient limitation as a result of fasting include: autophagy, glucose regulation, hormone regulation, and circadian rhythm. Although fasting has been implicated to rewire biological processes in the human body, it remains unclear whether fasting has any beneficial health implications. Knowing the full effects of fasting can provide insight on human biological systems and solidify the potential of utilizing fasting as a non-invasive preventive measure for human disease. In this review, we highlight the biological processes fasting affects, and utilizing the research articles we have concluded that fasting is a largely beneficial practice but more clinical studies need to be done to solidify conclusions.
References
Yiren Wang, Ruilin Wu, "The Effect of Fasting on Human Metabolism and Psychological Health", Disease Markers, vol. 2022, Article ID 5653739, 7 pages, 2022. https://doi.org/10.1155/2022/5653739
Jeffrey D. Browning, Jeannie Baxter, Santhosh Satapati, Shawn C. Burgess, “The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men”, PATIENT-ORIENTED AND EPIDEMIOLOGICAL RESEARCH VOLUME 53, ISSUE 3, P577-586, MARCH 2012. https://doi.org/10.1194/jlr.P020867
Shah A, Wondisford FE. Gluconeogenesis Flux in Metabolic Disease. Annu Rev Nutr. 2023 Aug 21;43:153-177. doi: 10.1146/annurev-nutr-061121-091507.
Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol. 2010 May;221(1):3-12. doi: 10.1002/path.2697. PMID: 20225336; PMCID: PMC2990190.
Bagherniya M, Butler AE, Barreto GE, Sahebkar A. The effect of fasting or calorie restriction on autophagy induction: A review of the literature. Ageing Res Rev. 2018 Nov;47:183-197. doi: 10.1016/j.arr.2018.08.004. Epub 2018 Aug 30. PMID: 30172870.
Ulgherait M, Midoun AM, Park SJ, Gatto JA, Tener SJ, Siewert J, Klickstein N, Canman JC, Ja WW, Shirasu-Hiza M. Circadian autophagy drives iTRF-mediated longevity. Nature. 2021 Oct;598(7880):353-358. doi: 10.1038/s41586-021-03934-0. Epub 2021 Sep 29. PMID: 34588695; PMCID: PMC9395244.
Yin Z, Klionsky DJ. Intermittent time-restricted feeding promotes longevity through circadian autophagy. Autophagy. 2022 Mar;18(3):471-472. doi: 10.1080/15548627.2022.2039524. Epub 2022 Feb 27. PMID: 35220894; PMCID: PMC9037462.
Kim BH, Joo Y, Kim MS, Choe HK, Tong Q, Kwon O. Effects of Intermittent Fasting on the Circulating Levels and Circadian Rhythms of Hormones. Endocrinol Metab (Seoul). 2021 Aug;36(4):745-756. doi: 10.3803/EnM.2021.405. Epub 2021 Aug 27. PMID: 34474513; PMCID: PMC8419605.
Varkaneh Kord H, M Tinsley G, O Santos H, Zand H, Nazary A, Fatahi S, Mokhtari Z, Salehi-Sahlabadi A, Tan SC, Rahmani J, Gaman MA, Sathian B, Sadeghi A, Hatami B, Soltanieh S, Aghamiri S, Bawadi H, Hekmatdoost A. The influence of fasting and energy-restricted diets on leptin and adiponectin levels in humans: A systematic review and meta-analysis. Clin Nutr. 2021 Apr;40(4):1811-1821. doi: 10.1016/j.clnu.2020.10.034. Epub 2020 Oct 24. PMID: 33158587.
Al-Rawi N, Madkour M, Jahrami H, Salahat D, Alhasan F, BaHammam A, Al-Islam Faris M. Effect of diurnal intermittent fasting during Ramadan on ghrelin, leptin, melatonin, and cortisol levels among overweight and obese subjects: A prospective observational study. PLoS One. 2020 Aug 26;15(8):e0237922. doi: 10.1371/journal.pone.0237922. PMID: 32845924; PMCID: PMC7449475.
Webber J, Taylor J, Greathead H, Dawson J, Buttery PJ, Macdonald IA. The effects of fasting on the thermogenic, metabolic and cardiovascular responses to infused adrenaline. Br J Nutr. 1995 Oct;74(4):477-90. doi: 10.1079/bjn19950152. PMID: 7577887.
Kolanowski J. Influence of insulin and glucagon on sodium balance in obese subjects during fasting and refeeding. Int J Obes. 1981;5 suppl 1:105-14. PMID: 6113218.
Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017 Oct;39:46-58. doi: 10.1016/j.arr.2016.10.005. Epub 2016 Oct 31. PMID: 27810402; PMCID: PMC5411330.
Varady KA, Cienfuegos S, Ezpeleta M, Gabel K. Cardiometabolic Benefits of Intermittent Fasting. Annu Rev Nutr. 2021 Oct 11;41:333-361. doi: 10.1146/annurev-nutr-052020-041327. PMID: 34633860.
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