Preprint / Version 4

The Association Between Genes in Ethnic Cohorts and Acute Lymphoblastic Leukemia

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  • Vivek Nalluri Polygence

DOI:

https://doi.org/10.58445/rars.74

Keywords:

biology, leukemia, acute lymphoblastic leukemia, ALL, cancer, oncology, genes

Abstract

Acute lymphoblastic leukemia (ALL) is a blood cancer which commonly affects children and progresses rapidly. While comparative analyses have been performed between ALL survival rates of children of various races, there remains a lack of knowledge about patterns of commonly expressed genes within different ethnic cohorts who have ALL. Thus, it is critical to identify common genes that are expressed in various ethnic youth cohorts affected by ALL to understand how these genes may be targeted in future ALL therapies. 

References

Acute Lymphocytic Leukemia. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/acute-lymphocytic-leukemia/symptoms-causes/syc-20369077.

Puckett Y, Chan O. Acute Lymphocytic Leukemia. [Updated 2022 Jun 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459149/

Acute Lymphoblastic Leukemia (ALL). St. Jude Children’s Research Hospital. https://www.stjude.org/disease/acute-lymphoblastic-leukemia-all.html

Bhatia, et al. Racial and ethnic differences in survival of children with acute lymphoblastic leukemia. The American Society of Hematology. 2002;100:6

Wiemels, et al. GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nat Commun. 2018 Jan 18;9(1):286.

Yan, et al. Association of XRCC3 Thr241Met polymorphism and leukemia risk: evidence from a meta-analysis. 2014; 55(9): 2130–2134

Xie, et al. Ethnicity-stratifed analysis of the association between XRCC3 Thr241Met polymorphism and leukemia: an updated meta-analysis. 2021; 14:229

Archer NP, Perez-Andreu V, Stoltze U, Scheurer ME, Wilkinson AV, Lin T-N, et al. (2017)

Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility. PLoS ONE 12(8): e0180488. https:// doi.org/10.1371/journal.pone.0180488

Xu, et al. ARID5B Genetic Polymorphisms Contribute to Racial Disparities in the Incidence and Treatment Outcome of Childhood Acute Lymphoblastic Leukemia. J Clin Oncol. 2012;30:751-757.

Xu, et al. Novel Susceptibility Variants at 10p12.31-12.2 for Childhood Acute Lymphoblastic Leukemia in Ethnically Diverse Populations. J Natl Cancer Inst. 2013;105:733–742.

Yang, et al. FOXO3 gene polymorphisms influence the risk of acute lymphoblastic leukemia in Chinese children. J Cell Biochem. 2020;121:2019–2026.

Wang, et al. Association of the 3’UTR FOXO3a Polymorphism rs4946936 with an increased risk of childhood acute lymphoblastic leukemia in a Chinese population. Cell Physio Biochem. 2014;34:325-332.

Wang Z, Zhang W. Association between XRCC3 Thr241Met polymorphism and colorectal cancer risk. Tumour Biol. 2013 Jun;34(3):1421-9.

Zhang J, Hou S, You Z, Li G, Xu S, Li X, Zhang X, Lei B, Pang D. Expression and prognostic values of ARID family members in breast cancer. Aging (Albany NY). 2021 Feb 11;13(4):5621-5637.

Lim B, Park JL, Kim HJ, Park YK, Kim JH, Sohn HA, Noh SM, Song KS, Kim WH, Kim YS, Kim SY. Integrative genomics analysis reveals the multilevel dysregulation and oncogenic characteristics of TEAD4 in gastric cancer. Carcinogenesis. 2014 May;35(5):1020-7.

Habrowska-Górczyńska DE, Kozieł MJ, Kowalska K, Piastowska-Ciesielska AW. FOXO3a and Its Regulators in Prostate Cancer. Int J Mol Sci. 2021 Nov 20;22(22):12530.

Hiraku Y, Kawanishi S. Oxidative DNA damage and apoptosis induced by benzene metabolites. Cancer Res. 1996;56(22):5172-8.

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2022-11-28 — Updated on 2022-12-23

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