High Fructose Corn Syrup and its Relations to the Gut Microbiome
DOI:
https://doi.org/10.58445/rars.727Keywords:
gut microbiome, obesity, high fructose corn syrupAbstract
This research paper delves into the intricate relationships between High Fructose Corn Syrup (HFCS) consumption, obesity, and the gut microbiome. HFCS, a commonly used sweetener in processed foods, is scrutinized for its potential role in obesity due to its unique metabolic pathways and effects on the gut microbiome. The study examines the economic and historical factors behind HFCS's prominence in the food industry, highlighting its distinctive metabolic consequences. It also explores how HFCS may disrupt the gut microbiome, contributing to imbalances in nutrient utilization and metabolic repercussions. While the paper emphasizes the complexity of these relationships, it underscores the need for further research to comprehensively understand the interactions and inform public health strategies.
References
Beisner, J., Gonzalez-Granda, A., Basrai, M., Damms-Machado, A., & Bischoff, S. C. (2020). Fructose-Induced Intestinal Microbiota Shift Following Two Types of Short-Term High-Fructose Dietary Phases. Nutrients, 12(11), 3444. https://doi.org/10.3390/nu12113444
Chakaroun, R. M., Massier, L., & Kovacs, P. (2020). Gut Microbiome, Intestinal Permeability, and Tissue Bacteria in Metabolic Disease: Perpetrators or Bystanders?. Nutrients, 12(4), 1082. https://doi.org/10.3390/nu12041082
Chakraborti, A., Graham, C., Chehade, S., Vashi, B., Umfress, A., Kurup, P., Vickers, B., Chen, H. A., Telange, R., Berryhill, T., Van Der Pol, W., Powell, M., Barnes, S., Morrow, C., Smith, D. L., Jr, Mukhtar, M. S., Watts, S., Kennedy, G., & Bibb, J. (2021). High Fructose Corn Syrup-Moderate Fat Diet Potentiates Anxio-Depressive Behavior and Alters Ventral Striatal Neuronal Signaling. Frontiers in neuroscience, 15, 669410. https://doi.org/10.3389/fnins.2021.669410
Douard, V., & Ferraris, R. P. (2008). Regulation of the fructose transporter GLUT5 in health and disease. American journal of physiology. Endocrinology and metabolism, 295(2), E227–E237. https://doi.org/10.1152/ajpendo.90245.2008
Duffey, K. J., & Popkin, B. M. (2008). High-fructose corn syrup: is this what's for dinner?. The American journal of clinical nutrition, 88(6), 1722S–1732S. https://doi.org/10.3945/ajcn.2008.25825C
Johnson, R. J., Perez-Pozo, S. E., Sautin, Y. Y., Manitius, J., Sanchez-Lozada, L. G., Feig, D. I., Shafiu, M., Segal, M., Glassock, R. J., Shimada, M., Roncal, C., & Nakagawa, T. (2009). Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?. Endocrine reviews, 30(1), 96–116. https://doi.org/10.1210/er.2008-0033
Kim J. Y. (2021). Optimal Diet Strategies for Weight Loss and Weight Loss Maintenance. Journal of obesity & metabolic syndrome, 30(1), 20–31. https://doi.org/10.7570/jomes20065
Leeming, E. R., Johnson, A. J., Spector, T. D., & Le Roy, C. I. (2019). Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration. Nutrients, 11(12), 2862. https://doi.org/10.3390/nu11122862
Liao, Y., Davies, N. A., & Bogle, I. D. L. (2020). Computational Modeling of Fructose Metabolism and Development in NAFLD. Frontiers in bioengineering and biotechnology, 8, 762. https://doi.org/10.3389/fbioe.2020.00762
Ma, X., Nan, F., Liang, H., Shu, P., Fan, X., Song, X., Hou, Y., & Zhang, D. (2022). Excessive intake of sugar: An accomplice of inflammation. Frontiers in immunology, 13, 988481. https://doi.org/10.3389/fimmu.2022.988481
Mai, B. H., & Yan, L. J. (2019). The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders. Diabetes, metabolic syndrome and obesity : targets and therapy, 12, 821–826. https://doi.org/10.2147/DMSO.S198968
Malik, V. S., & Hu, F. B. (2015). Fructose and Cardiometabolic Health: What the Evidence From Sugar-Sweetened Beverages Tells Us. Journal of the American College of Cardiology, 66(14), 1615–1624. https://doi.org/10.1016/j.jacc.2015.08.025
McAllister, E. J., Dhurandhar, N. V., Keith, S. W., Aronne, L. J., Barger, J., Baskin, M., Benca, R. M., Biggio, J., Boggiano, M. M., Eisenmann, J. C., Elobeid, M., Fontaine, K. R., Gluckman, P., Hanlon, E. C., Katzmarzyk, P., Pietrobelli, A., Redden, D. T., Ruden, D. M., Wang, C., Waterland, R. A., … Allison, D. B. (2009). Ten putative contributors to the obesity epidemic. Critical reviews in food science and nutrition, 49(10), 868–913. https://doi.org/10.1080/10408390903372599
Pereira, R. M., Botezelli, J. D., da Cruz Rodrigues, K. C., Mekary, R. A., Cintra, D. E., Pauli, J. R., da Silva, A. S. R., Ropelle, E. R., & de Moura, L. P. (2017). Fructose Consumption in the Development of Obesity and the Effects of Different Protocols of Physical Exercise on the Hepatic Metabolism. Nutrients, 9(4), 405. https://doi.org/10.3390/nu9040405
Rippe, J. M., & Angelopoulos, T. J. (2013). Sucrose, high-fructose corn syrup, and fructose, their metabolism and potential health effects: what do we really know?. Advances in nutrition (Bethesda, Md.), 4(2), 236–245. https://doi.org/10.3945/an.112.002824
Rizkalla S. W. (2010). Health implications of fructose consumption: A review of recent data. Nutrition & metabolism, 7, 82. https://doi.org/10.1186/1743-7075-7-82
Sanmiguel, C., Gupta, A., & Mayer, E. A. (2015). Gut Microbiome and Obesity: A Plausible Explanation for Obesity. Current obesity reports, 4(2), 250–261. https://doi.org/10.1007/s13679-015-0152-0
Softic, S., Gupta, M. K., Wang, G. X., Fujisaka, S., O'Neill, B. T., Rao, T. N., Willoughby, J., Harbison, C., Fitzgerald, K., Ilkayeva, O., Newgard, C. B., Cohen, D. E., & Kahn, C. R. (2017). Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. The Journal of clinical investigation, 127(11), 4059–4074. https://doi.org/10.1172/JCI94585
Stanhope, K. L., & Havel, P. J. (2008). Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrup. The American journal of clinical nutrition, 88(6), 1733S–1737S. https://doi.org/10.3945/ajcn.2008.25825D
Wang, X., Zhu, L., Li, X., Wang, X., Hao, R., & Li, J. (2022). Effects of high fructose corn syrup on intestinal microbiota structure and obesity in mice. NPJ science of food, 6(1), 17. https://doi.org/10.1038/s41538-022-00133-7
Wilk, K., Korytek, W., Pelczyńska, M., Moszak, M., & Bogdański, P. (2022, March 16). The effect of artificial sweeteners use on sweet taste perception and weight loss efficacy: A Review. Nutrients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954878/
Yeung AY, Tadi P. Physiology, Obesity Neurohormonal Appetite And Satiety Control. [Updated 2023 Jan 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK555906/
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