Preprint / Version 1

Investigation of 6 Vulnerable Strains of MRSA, High Areas of Occurrence for MRSA, and Protein Structure and Function Variants for BlaZ gene.


  • Hasika Oggi Branham High School



MRSA, Protein Structure, BlaZ gene


Methicillin-resistant Staphylococcus aureus is a bacterium that is quickly developing resistance to many antibiotics including methicillin, penicillin, beta-lactam antibiotics and more. It causes many infections and can be fatal in some cases if not diagnosed and treated properly. While MRSA incidence has declined in some regions, it still is a clinical threat due to its high level of resistance to modern antibiotics. Successfully eradicating MRSA will take time, but this review aims to look at the gene diversity between various strains of MRSA. This ultimately can be useful for doctors when deciding the most effective treatment regimen for a patient. NCBI, PathogenWatch, and BLAST were used to search for MRSA strains and discover what they were resistant to. NCBI was used to download various genome assemblies using the search terms Staphylococcus aureus and to look at papers that provided further information on the onset and problems that MRSA causes. PathogenWatch was used to keep track of all the assemblies and to create a tree that would clearly showcase resistance genes present in the genomes. Finally, BLAST was used to check for gene diversity and see what genes would MRSA be most resistant to. I blasted 51 MRSA strains that are included in this paper and concluded that gene diversity is present in all but 6 strains which are extremely vulnerable to any sort of treatment. Most commonly, the resistance genes were mecA, tetM, and ermA, the most popular types of antibiotics used to treat MRSA. It is imperative that more successful treatments be created for MRSA, but until then, we may have to resort to using multiple antibiotics to treat this disease. Possible treatments for MRSA may include multi-drug therapy or alternative therapeutic treatments.


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