Preprint / Version 1

The Impact of Diet and Environmental Factors on Hashimoto's Thyroiditis

##article.authors##

  • Deekshitha Vinod Bridgewater Raritan High School

DOI:

https://doi.org/10.58445/rars.539

Keywords:

Autoimmune Diseases, Thyroid, Hashimoto's Thyroiditis, Hashimoto's Disease, Hypothyroidism

Abstract

Hashimoto’s Thyroiditis, also known as Hashimoto’s Disease, is an autoimmune disease that causes the thyroid gland to be underactive. An underactive thyroid gland leads to hypothyroidism, in which antibodies made by the immune system attack the thyroid gland, leading to an accumulation of white blood cells and damage to the gland. This means that a lower number of thyroid hormones are produced. Typically the most common cause of hypothyroidism, Hashimoto’s Thyroiditis is estimated to have an incidence rate of 0.8/1000 per year for men and 3.5/1000 per year for women (Mincer and Jialal). Although there are some therapies to manage the disease like thyroid hormone replacement and levothyroxine, there is no permanent cure as the medication would have to be continued for life (Wartofsky). The development of Hashimoto’s Disease can be linked to family history/genes and viral infections such as Hepatitis C. Environmental and lifestyle factors like exercise, chemicals, and drugs can also be connected to the progression of Hashimoto’s Thyroiditis. Additionally, there is evidence to support the idea that dietary components, like sugars and gluten, also play a role in the symptoms and development of Hashimoto’s Disease. This paper explores the impact of dietary components and environmental influences, like viral infections, on Hashimoto’s Thyroiditis. 

References

Bellinger, Frederick P., et al. “Regulation and Function of Selenoproteins in Human Disease.” Biochemical Journal, vol. 422, no. 1, 29 July 2009, pp. 11–22, https://doi.org/10.1042/bj20090219.

Conlon, Michael, and Anthony Bird. “The Impact of Diet and Lifestyle on Gut Microbiota and Human Health.” Nutrients, vol. 7, no. 1, 24 Dec. 2014, pp. 17–44, www.ncbi.nlm.nih.gov/pmc/articles/PMC4303825/, https://doi.org/10.3390/nu7010017.

Delange, François, et al. “Determining Median Urinary Iodine Concentration That Indicates Adequate Iodine Intake at Population Level.” Bulletin of the World Health Organization, vol. 80, 2002, pp. 633–636, www.ncbi.nlm.nih.gov/pmc/articles/PMC2567591/pdf/12219154.pdf..

“Food Additives.” Www.who.int, www.who.int/news-room/fact-sheets/detail/food-additives#:~:text=Substances%20that%20are%20added%20to.

“Hashimoto’s Thyroiditis.” Www.hopkinsmedicine.org, 8 Aug. 2021, www.hopkinsmedicine.org/health/conditions-and-diseases/hashimotos-thyroiditis#:~:text=Thyroiditis%20is%20when%20your%20thyroid.

Kaličanin, Dean, et al. “Differences in Food Consumption between Patients with Hashimoto’s Thyroiditis and Healthy Individuals.” Scientific Reports, vol. 10, no. 1, 30 June 2020, https://doi.org/10.1038/s41598-020-67719-7.

Li, Dapeng, et al. “Th17 Cell Plays a Role in the Pathogenesis of Hashimoto’s Thyroiditis in Patients.” Clinical Immunology, vol. 149, no. 3, 1 Dec. 2013, pp. 411–420, https://doi.org/10.1016/j.clim.2013.10.001.

Ludwig, Ralf J., et al. “Mechanisms of Autoantibody-Induced Pathology.” Frontiers in Immunology, vol. 8, 31 May 2017, https://doi.org/10.3389/fimmu.2017.00603.

Mackawy, Amal Mohammed Husein, et al. “Vitamin D Deficiency and Its Association with Thyroid Disease.” International Journal of Health Sciences, vol. 7, no. 3, 2013, pp. 267–75, www.ncbi.nlm.nih.gov/pmc/articles/PMC3921055/.

Mayo Clinic. “Hashimoto’s Disease - Symptoms and Causes.” Mayo Clinic, 2020, www.mayoclinic.org/diseases-conditions/hashimotos-disease/symptoms-causes/syc-20351855.

Mazzucca, Camilla Barbero, et al. “How to Tackle the Relationship between Autoimmune Diseases and Diet: Well Begun Is Half-Done.” Nutrients, vol. 13, no. 11, 5 Nov. 2021, p. 3956, https://doi.org/10.3390/nu13113956.

McMurray, Robert G, and Keith B Elbourne. “Hepatitis c Virus Infection and Autoimmunity.” Seminars in Arthritis and Rheumatism, vol. 26, no. 4, 1 Feb. 1997, pp. 689–701, https://doi.org/10.1016/s0049-0172(97)80005-4.

Medline Plus. “Autoimmune Disorders: MedlinePlus Medical Encyclopedia.” Medlineplus.gov, 2017, medlineplus.gov/ency/article/000816.htm.

Mikulska, Aniceta A., et al. “Metabolic Characteristics of Hashimoto’s Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management—an Overview.” International Journal of Molecular Sciences, vol. 23, no. 12, 1 Jan. 2022, p. 6580, www.mdpi.com/1422-0067/23/12/6580/htm, https://doi.org/10.3390/ijms23126580.

Mincer, Dana L, and Ishwarlal Jialal. “Hashimoto Thyroiditis.” Nih.gov, StatPearls Publishing, 5 May 2019, www.ncbi.nlm.nih.gov/books/NBK459262/.

“Office of Dietary Supplements - Vitamin D.” Ods.od.nih.gov, ods.od.nih.gov/factsheets/VitaminD-Consumer/#:~:text=Levels%20of%2050%20nmol%2FL.

Pastore, Francesca, et al. “Hepatitis c Virus Infection and Thyroid Autoimmune Disorders: A Model of Interactions between the Host and the Environment.” World Journal of Hepatology, vol. 8, no. 2, 18 Jan. 2016, pp. 83–91, pubmed.ncbi.nlm.nih.gov/26807204/, https://doi.org/10.4254/wjh.v8.i2.83.

Sundaresan, Bhargavi, et al. “The Role of Viral Infections in the Onset of Autoimmune Diseases.” Viruses, vol. 15, no. 3, 1 Mar. 2023, p. 782, www.mdpi.com/1999-4915/15/3/782#:~:text=Viral%20infections%20are%20one%20of, https://doi.org/10.3390/v15030782. Accessed 28 Apr. 2023.

“Thyroid Antibodies: MedlinePlus Lab Test Information.” Medlineplus.gov, 15 Dec. 2020, medlineplus.gov/lab-tests/thyroid-antibodies/.

Ventura, Mara, et al. “Selenium and Thyroid Disease: From Pathophysiology to Treatment.” International Journal of Endocrinology, 2017, www.hindawi.com/journals/ije/2017/1297658/.

Wartofsky, Leonard. “Hashimoto’s Disease.” National Institute of Diabetes and Digestive and Kidney Diseases, 5 Apr. 2019, www.niddk.nih.gov/health-information/endocrine-diseases/hashimotos-disease.

Wentz, Izabella. “The Effect of Iodine on Hashimoto’s - Dr. Izabella Wentz.” Dr. Izabella Wentz, PharmD, 15 Jan. 2021, thyroidpharmacist.com/articles/iodine-hashimotos/#:~:text=While%20iodine%20deficiency%20can%20cause. Accessed 31 Aug. 2023.

Wimmer, I., et al. “Selenium Levels in Patients with Autoimmune Thyroiditis and Controls in Lower Austria.” Hormone and Metabolic Research, vol. 46, no. 10, 30 June 2014, pp. 707–709, https://doi.org/10.1055/s-0034-1377029.

Downloads

Posted

2023-10-08

Categories