Preprint / Version 1

Mechanisms of Cancer Resistance Across Mammals

##article.authors##

  • Amari Anderson N/A

DOI:

https://doi.org/10.58445/rars.499

Keywords:

cancer, resistance, mammals

Abstract

Cancer is a complex disease that threatens the health of a broad range of species. Despite the fact that cancer is the second leading cause of death worldwide, there are a number of species that are remarkably resistant to cancer, including the elephant, naked mole rat, blind mole rat, whale, horse, cow, and microbat. These animals exhibit a natural resistance to cancer through various mechanisms, including enhanced DNA repair, hypersensitivity to genotoxic stress, resistance to metastatic invasion, and duplicate copies of tumor suppressor genes. These mechanisms can provide insight into preventing, as well as treating, cancer in less resistant species. This paper reviews potential mechanisms for cancer resistance across a variety of mammals and provides insight as to why some mammals are more resistant to cancer than others. 

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