Exploring the Intersection of Alzheimer's Disease and Vascular Factors
DOI:
https://doi.org/10.58445/rars.457Keywords:
Neuroscience, Alzheimer's Disease, Vascular, Neurodegenerative DisorderAbstract
Alzheimer's Disease (AD) and vascular risk factors have long been investigated as separate entities within the fields of neuroscience and medicine. However, emerging evidence suggests a complex connection between these two factors, leading to a need in the reevaluation of their relationship. This review implements an integrative review approach, utilizing evidence from epidemiological studies, neuroimaging, genetics, and molecular investigations. Ultimately, this paper underscores the need for a holistic understanding of AD pathogenesis that incorporates vascular factors into the disease model. Utilizing such multidisciplinary strategies paves the way to the development of novel therapeutics and therapies for AD in the future.
References
Alzheimer's Association. (2020). Alzheimer's disease facts and figures. Alzheimer's & Dementia, 16(3), 391-460.
Biessels, G. J., Strachan, M. W., Visseren, F. L., Kappelle, L. J., & Whitmer, R. A. (2014). Dementia and cognitive decline in type 2 diabetes and prediabetic stages: Towards targeted interventions. The Lancet Diabetes & Endocrinology, 2(3), 246-255.
Chen, X., Guo, C., Kong, J., Oxenkrug, G., & Cui, Q. (2020). The interaction between mitochondrial dysfunction and inflammation in Alzheimer's disease. Frontiers in Aging Neuroscience, 12, 188.
Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., ... & Schneider, J. A. (2011). Vascular contributions to cognitive impairment and dementia: A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 42(9), 2672-2713.
Hardy, J., & Selkoe, D. J. (2002). The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science, 297(5580), 353-356.
Kivipelto, M., Helkala, E. L., Hänninen, T., Laakso, M. P., Hallikainen, M., Alhainen, K., ... & Nissinen, A. (2001). Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study. Neurology, 56(12), 1683-1689.
Ladecola, C., Gottesman, R. F., & Moskowitz, M. A. (2019). Hypertension and dementia. Hypertension, 74(2), 171-179.
Rensma, S. P., van Sloten, T. T., Launer, L. J., Stehouwer, C. D., & Cordonnier, C. (2018). Cerebral small vessel disease and risk of incident stroke, dementia, and depression, and all-cause mortality: A systematic review and meta-analysis. Neurology, 91(8), e832-e842.
Power MC, Weuve J, Gagne JJ, McQueen MB, Viswanathan A, Blacker D. The association between blood pressure and incident Alzheimer disease: a systematic review and meta-analysis. Epidemiology. 2011 Sep;22(5):646-59. doi: 10.1097/EDE.0b013e31822708b5. PMID: 21705906; PMCID: PMC3640480.
Sasaki, N., Fukatsu, R., Tsuzuki, K., Hayashi, Y., Yoshida, T., Fujii, N., & Koike, T. (2018). Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases. The American Journal of Pathology, 153(4), 1149-1155.
Snyder HM, Asthana S, Bain L, Brinton R, Craft S, Dubal DB, Espeland MA, Gatz M, Mielke MM, Raber J, Rapp PR, Yaffe K, Carrillo MC. Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative. Alzheimers Dement. 2016 Nov;12(11):1186-1196. doi: 10.1016/j.jalz.2016.08.004. Epub 2016 Sep 27. PMID: 27692800; PMCID: PMC10341380.
Vemuri, P., Lesnick, T. G., Przybelski, S. A., Graff-Radford, J., Reid, R. I., Lowe, V. J., ... & Jack Jr, C. R. (2020). Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging. Annals of Neurology, 88(3), 434-449.
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