Preprint / Version 1

The Relationship Between Human Exposure to Drug-Resistant Fungi and Climate Change

##article.authors##

  • Jui Park Georgia

DOI:

https://doi.org/10.58445/rars.4083

Keywords:

Climate Change, Antifungal Resistance, Drug-Resistant Fungi, Fungal Pathogens, Candida auris, Global Warning, Human Exposure, Environmental Reservoirs, Fungal Infections, Public Health

Abstract

With average global temperatures rising, the climate crisis continues to be exacerbated.

Although climate change causes a plethora of environmental issues, it also directly affects

human health on a global scale. Due to the steep increase of global temperatures, pathogens

are able to adapt to new environments at faster rates as the warming accelerates. Moreover, as

environmental temperatures rise, fungi adapt to higher temperatures, and this adjustment allows

these pathogens to bypass the human body’s natural heat defense and survive within the body’s

systems. Additionally, global warming is also responsible for creating heat stress, which has

been linked to accelerated mutations in pathogenic fungi and accelerates adaptation. Ultimately,

this literary review aims to analyze the correlation between global warming and the prevalence

of drug-resistent fungi. The review analyzes the strength of this relationship by determining the

impact of this rise in fungal pathogens due to climate change on patients and individuals

world-wide and various mitigation strategies.

References

. Abdelmohsen, U. R., Balasubramanian, S., Oelschlaeger, T. A., Grkovic, T., Pham, N. B.,

Quinn, R. J., & Hentschel, U. (2016). Potential of marine natural products against

drug-resistant fungal, viral, and parasitic infections. The Lancet Infectious Diseases,

(2), e30–e41. https://doi.org/10.1016/s1473-3099(16)30323-1

. Akinbobola, A., Kean, R., & Quilliam, R. S. (2023). Plastic pollution as a novel reservoir for

the environmental survival of the drug resistant fungal pathogen Candida auris. Marine

Pollution Bulletin, 198, 115841. https://doi.org/10.1016/j.marpolbul.2023.115841

. Arastehfar, A., Lass-Flörl, C., Garcia-Rubio, R., Daneshnia, F., Ilkit, M., Boekhout, T.,

Gabaldon, T., & Perlin, D. S. (2020). The Quiet and Underappreciated Rise of

Drug-Resistant Invasive Fungal Pathogens. Journal of Fungi, 6(3), 138.

https://doi.org/10.3390/jof6030138

. Bendary, M. M., El-Hamid, M. I. A., Abousaty, A. I., Elmanakhly, A. R., Alshareef, W. A.,

Mosbah, R. A., Alhomrani, M., Ghoneim, M. M., Elkelish, A., Hashim, N., Alamri, A. S.,

Al-Harthi, H. F., & Safwat, N. A. (2023). Therapeutic Switching of Rafoxanide: a New

Approach To Fighting Drug-Resistant Bacteria and Fungi. Microbiology Spectrum, 11(4),

e0267922. https://doi.org/10.1128/spectrum.02679-22

. Chang, Z., Yadav, V., Lee, S. C., & Heitman, J. (2019). Epigenetic mechanisms of drug

resistance in fungi. Fungal Genetics and Biology, 132, 103253.

https://doi.org/10.1016/j.fgb.2019.103253

. Chen, X., Duan, H. D., Hoy, M. J., Koteva, K., Spitzer, M., Guitor, A. K., Puumala, E., Fiebig,

A. A., Hu, G., Yiu, B., Chou, S., Bian, Z., Choi, Y., Guo, A. B. Y., Wang, W., Sun, S.,

Robbins, N., Averette, A. F., Cook, M. A., . . . Wright, G. D. (2025). Butyrolactol A

enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi. Cell, 189(2),

-639.e28. https://doi.org/10.1016/j.cell.2025.11.036

. Engle, K., & Kumar, G. (2024). Tackling multi-drug resistant fungi by efflux pump inhibitors.

Biochemical Pharmacology, 226, 116400. https://doi.org/10.1016/j.bcp.2024.116400

. Fisher, M. C., Hawkins, N. J., Sanglard, D., & Gurr, S. J. (2018). Worldwide emergence of

resistance to antifungal drugs challenges human health and food security. Science,

(6390), 739–742. https://doi.org/10.1126/science.aap7999

. Garvey, M., Kremer, T. A., & Rowan, N. J. (2025). Efficacy of cleaning, disinfection, and

sterilization modalities for addressing infectious drug-resistant fungi: a review. Journal of

Applied Microbiology, 136(1). https://doi.org/10.1093/jambio/lxaf005

. Garvey, M., & Rowan, N. J. (2023). Pathogenic Drug Resistant Fungi: A Review of

Mitigation Strategies. International Journal of Molecular Sciences, 24(2), 1584.

. Gharehbolagh, S. A., Izadi, A., Talebi, M., Sadeghi, F., Zarrinnia, A., Zarei, F., Darmiani, K.,

Borman, A. M., & Mahmoudi, S. (2021). New weapons to fight a new enemy: A

systematic review of drug combinations against the drug‐resistant fungus Candida auris.

Mycoses, 64(11), 1308–1316. https://doi.org/10.1111/myc.13277

. Jaggi, T. K., Agarwal, R., Tiew, P. Y., Shah, A., Lydon, E. C., Hage, C. A., Waterer, G. W.,

Langelier, C. R., Delhaes, L., & Chotirmall, S. H. (2024). Fungal lung disease. European

Respiratory Journal, 64(5), 2400803. https://doi.org/10.1183/13993003.00803-2024

. Jiang, B., Lai, Y., Xiao, W., Zhong, T., Liu, F., Gong, J., & Huang, J. (2024). Microbial

extracellular vesicles contribute to antimicrobial resistance. PLoS Pathogens, 20(5),

e1012143. https://doi.org/10.1371/journal.ppat.1012143

. Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2020). Antifungal Drug Resistance:

Molecular Mechanisms in Candida albicans and Beyond. Chemical Reviews, 121(6),

–3411. https://doi.org/10.1021/acs.chemrev.0c00199

. Lockhart, S. R., Chowdhary, A., & Gold, J. a. W. (2023). The rapid emergence of

antifungal-resistant human-pathogenic fungi. Nature Reviews Microbiology, 21(12),

–832. https://doi.org/10.1038/s41579-023-00960-9

. McCarthy, M. W., Kontoyiannis, D. P., Cornely, O. A., Perfect, J. R., & Walsh, T. J. (2017).

Novel agents and drug targets to meet the challenges of resistant fungi. The Journal of

Infectious Diseases, 216(suppl_3), S474–S483. https://doi.org/10.1093/infdis/jix130

. Osmanov, A., Wise, A., & Denning, D. W. (2019). In vitro and in vivo efficacy of miramistin

against drug-resistant fungi. Journal of Medical Microbiology, 68(7), 1047–1052.

https://doi.org/10.1099/jmm.0.001007

. Revie, N. M., Iyer, K. R., Robbins, N., & Cowen, L. E. (2018). Antifungal drug resistance:

evolution, mechanisms and impact. Current Opinion in Microbiology, 45, 70–76.

https://doi.org/10.1016/j.mib.2018.02.005

. Silva, I., Miranda, I. M., & Costa-de-Oliveira, S. (2024). Potential environmental reservoirs

of Candida auris: A systematic review. Journal of Fungi, 10(5), 336.

https://doi.org/10.3390/jof10050336

. Wiederhold, N. P. (2021). Emerging fungal infections: new species, new names, and

antifungal resistance. Clinical Chemistry, 68(1), 83–90.

https://doi.org/10.1093/clinchem/hvab217

. Williams, S. L., Toda, M., Chiller, T., Brunkard, J. M., & Litvintseva, A. P. (2024). Effects of

climate change on fungal infections. PLoS Pathogens, 20(5), e1012219.

https://doi.org/10.1371/journal.ppat.1012219

Downloads

Posted

2026-08-19