A Mysterious Case of Pediatric Uveitis
DOI:
https://doi.org/10.58445/rars.3746Keywords:
uveitis, ocular inflammation, immune response, post-infectious uveitisAbstract
This case report involves a 10-year-old female who presented with acute onset of high fever, sore throat, rash, and new-onset blurry vision, later diagnosed as post-infectious uveitis, following an upper respiratory infection. Initial evaluation raised concern for Kawasaki disease, but it was ultimately ruled out. Further laboratory and imaging did not reveal signs of vasculitis, autoimmune disease, or systemic infection. Ophthalmologic examination revealed anterior chamber inflammation, vitritis, snowballing, and peripheral retinal phlebitis, confirming significant ocular inflammation. Despite using corticosteroid eye drops, the patient initially demonstrated persistent uveitis, requiring escalation to oral methotrexate. Over the following months, the uveitis gradually improved and then resolved completely, and the methotrexate and steroids were appropriately tapered off throughout that time. Long-term follow-up over several years has shown stable vision.
References
American Academy of Ophthalmology. (n.d.). Retinal vasculitis. EyeWiki. https://eyewiki.aao.org/Retinal_Vasculitis
American Academy of Ophthalmology. (n.d.). Uveitis. EyeWiki. https://eyewiki.org/Acute_Anterior_Uveitis
Asghar, M. A., Tang, S., Wong, L. P., Zhao, Q., & Yang, P. (2024). Infectious uveitis: A comprehensive systematic review of emerging trends and molecular pathogenesis using network analysis. Journal of Ophthalmic Inflammation and Infection, 14, 60. https://pubmed.ncbi.nlm.nih.gov/39565496/
Filloy, A., Comas, C., & Català‑Mora, J. (2016). Anterior and intermediate uveitis with retinal vasculitis: An unusual manifestation of post‑streptococcal uveitis syndrome. Ocular Immunology and Inflammation, 24(6), 607–609. https://pubmed.ncbi.nlm.nih.gov/26713592/
Mayo Clinic. (n.d.). Uveitis: Diagnosis and treatment. https://www.mayoclinic.org/diseases-conditions/uveitis/diagnosis-treatment/drc-20378739
Mayo Clinic. (n.d.). Uveitis: Symptoms and causes. https://www.mayoclinic.org/diseases-conditions/uveitis/symptoms-causes/syc-20378734
National Eye Institute. (n.d.). Uveitis. National Institutes of Health. https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/uveitis
O’Keefe, G. A. D. (2021). Retinal vasculitis: A framework and proposal for a classification system. Journal Name. https://pubmed.ncbi.nlm.nih.gov/32450158/
Sève, P., Cacoub, P., Bodaghi, B., et al. (2022). Retinal vasculitis: A comprehensive review. Journal of Clinical Medicine, 11(9), 9101900. https://pmc.ncbi.nlm.nih.gov/articles/PMC9101900/
StatPearls Publishing. (2024). Retinal vasculitis. In StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK540993/
Song, W., Au, A., Sarraf, D., Prasad, P., & Tsui, E. (2025). Bilateral acute multifocal retinitis and retinal vasculitis secondary to Rickettsia typhi infection. Journal of Ophthalmic Inflammation and Infection, 15, 38. https://pubmed.ncbi.nlm.nih.gov/40259155/
Testi, I., Fabozzi, L., & De Benito‑Llopis, L. (2023). Cytomegalovirus anterior uveitis and occlusive retinal vasculitis without retinitis in a patient on immunomodulatory therapy. Journal of Ophthalmic Inflammation and Infection, 13, 34. https://pmc.ncbi.nlm.nih.gov/articles/PMC10403449/
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