How Quantum Computing System Size and Performance Enhances the Drug Discovery Process for KRAS Mutants
DOI:
https://doi.org/10.58445/rars.3659Keywords:
Quantum Computing, Drug Discovery, KRAS MutantsAbstract
This study discusses the role of quantum computing in the drug discovery process for KRAS mutants and how larger qubit counts and increases in circuit depth can enhance the process. Increasing system size may offer improvements in the coming years. Specifically, as quantum computing enters the fault-tolerant era, algorithms requiring error-correction due to their long runtimes and sensitivity to noise can be used. By increasing the number of high-fidelity operations compared to today’s error-prone quantum computers, fault-tolerant systems will enable new classes of more capable algorithms and enhanced discovery of KRAS inhibitors. Lowering maintenance costs and increasing accessibility of quantum computers are necessary for a larger population to be able to make more rapid advancements in the field.
References
"Qubit - Quantum Computing Explained." Quandela, www.quandela.com/resources/quantum-computing-glossary/qubit/. Accessed 1 Jan. 2026.
"A Guide to Quantum Computers and the Development of Quantum Advantage." International Journal of High School Research, vol. 5, no. 3, 2023, p. 103, terra-docs.s3.us-east-2.amazonaws.com/IJHSR/Articles/volume5-issue3/IJHSR_2023_53_p103.pdf.
"Scientists Hit Quantum Computer Error Rate of 0.000015% — A World Record Achievement That Could Lead to Smaller and Faster Machines." Live Science, 28 July 2025, www.livescience.com/technology/computing/scientists-hit-quantum-computer-error-rate-of-0-000015-percent-a-world-record-achievement-that-could-lead-to-smaller-and-faster-machines.
"Global Quantum Computing Market to Grow." Yahoo Finance, finance.yahoo.com/news/global-quantum-computing-market-grow-191300732.html. Accessed 1 Jan. 2026.
"Quantum Computing Roadmaps: A Look at the Maps and Predictions of Major Quantum Players." The Quantum Insider, 16 May 2025, thequantuminsider.com/2025/05/16/quantum-computing-roadmaps-a-look-at-the-maps-and-predictions-of-major-quantum-players/.
Kulkarni, Sandeep, et al. Quantum Computing in Drug Discovery: A Review of Foundations and Emerging Applications. 2025, papers.ssrn.com/sol3/papers.cfm?abstract_id=5310140, https://doi.org/10.2139/ssrn.5310140. Accessed 7 Jan. 2026.
"The Convergence of Quantum Computing and Early Drug Discovery." Kvantify, www.kvantify.com/blog/the-convergence-of-quantum-computing-and-early-drug-discovery. Accessed 1 Jan. 2026.
"Quantum Computing Technology in Pharmaceutical R&D." Roots Analysis, 5 Sep. 2023, www.rootsanalysis.com/blog/quantum-computing-technology-in-pharma-research/.
Vakili, Mohammad Ghazi, et al. "Quantum-Computing-Enhanced Algorithm Unveils Potential KRAS Inhibitors." Nature Biotechnology, 2024, www.nature.com/articles/s41587-024-02526-3.
"The Quantum Advantage: Leveraging Community and Collaboration for Success." The Economist Impact, impact.economist.com/projects/state-of-quantum/digital-report/. Accessed 1 Jan. 2026.
"How Quantum Computing Is Revolutionising Drug Development." Drug Discovery World, 2025, www.ddw-online.com/how-quantum-computing-is-revolutionising-drug-development-34423-202504/.
"The Cost of Quantum Computing: How Expensive Is It to Run a Quantum System? (Stats Inside)." PatentPC, 22 Dec. 2025, patentpc.com/blog/the-cost-of-quantum-computing-how-expensive-is-it-to-run-a-quantum-system-stats-inside.
"IQM Spark." IQM Quantum Computers, meetiqm.com/products/iqm-spark/. Accessed 1 Jan. 2026.
Palma, Giacomo De, et al. “APS.” Limitations of Variational Quantum Algorithms: A Quantum Optimal Transport Approach, journals.aps.org/prxquantum/pdf/10.1103/PRXQuantum.4.010309. Accessed 7 Jan. 2026.
"MegaQuop: Paving the Way for Millions of Operations." Oxford Quantum Circuits (OQC), 6 Feb. 2025, oqc.tech/resources/beyond-the-bit/megaquop-paving-the-way-for-millions-of-operations/.
Benedetti, Marcello, et al. "Parameterized Quantum Circuits as Machine Learning Models." Quantum Science and Technology, vol. 4, no. 4, 2019, iopscience.iop.org/article/10.1088/2058-9565/ab4eb5.
Nielsen, Michael A., and Isaac L. Chuang. Quantum Computation and Quantum Information. Cambridge University Press, 2010. Prof. M. Cruz, profmcruz.wordpress.com/wp-content/uploads/2017/08/quantum-computation-and-quantum-information-nielsen-chuang.pdf.
Ku, Calvin, et al. "Benchmarking Quantum Simulation Methods." arXiv, 2 Oct. 2025, arXiv:2510.01710, arxiv.org/pdf/2510.01710.
Callison, A., et al. "Heisenberg-Limited Quantum Phase Estimation of Multiple Eigenvalues with Few Control Qubits." PRX Quantum, vol. 3, no. 010318, 2022, journals.aps.org/prxquantum/abstract/10.1103/PRXQuantum.3.010318.
Mi, Xiao, et al. "Hardware-Efficient Quantum Phase Estimation via Local Control." PRX Quantum, vol. 2, no. 030305, 2021, journals.aps.org/prxquantum/abstract/10.1103/PRXQuantum.2.030305.
"What Is Quantum Annealing." D-Wave Systems, support.dwavesys.com/hc/en-us/articles/360003680954-What-Is-Quantum-Annealing. Accessed 1 Jan. 2026.
Wegsman, Shalma. "Particle Physicists Detect ‘Magic’ at the Large Hadron Collider." Quanta Magazine, 25 Nov. 2025, www.quantamagazine.org/particle-physicists-detect-magic-at-the-large-hadron-collider-20251125/.
Oya, Yuko, and Tetsuya Mitsudomi. “Is Adagrasib Just Another Sotorasib?-Or, Should We Differentiate Their Usage According to Patients’ Clinical Presentation?” Translational Lung Cancer Research, U.S. National Library of Medicine, 31 May 2023, pmc.ncbi.nlm.nih.gov/articles/PMC10261865/.
“Quantum Circuit Born Machines.” APX Machine Learning, n.d., apxml.com/courses/fundamentals-quantum-machine-learning/chapter-5-quantum-neural-networks-architectures-training/quantum-circuit-born-machines.
“IonQ | Demystifying Logical Qubits and Fault Tolerance.” Ionq.com, 2025, www.ionq.com/blog/demystifying-logical-qubits-and-fault-tolerance. Accessed 7 Jan. 2026.
“Quantum Computing in Pharmaceutical and Biomedical Research.” PubMed Central, 2024, pmc.ncbi.nlm.nih.gov/articles/PMC11586987/.
“Chapter 14 Spin Qubits for Quantum Information Processing.” Spin Qubits for Quantum Information Processing, www.nii.ac.jp/qis/first-quantum/forStudents/lecture/pdf/noise/chapter14.pdf. Accessed 7 Jan. 2026.
Voorhoede, De. “Superposition and Entanglement.” Quantum Inspire, 2021, www.quantum-inspire.com/kbase/superposition-and-entanglement/.
Blume-Kohout, Robin, et al. “Demonstration of Qubit Operations below a Rigorous Fault Tolerance Threshold with Gate Set Tomography.” Nature News, Nature Publishing Group, 15 Feb. 2017, www.nature.com/articles/ncomms14485?utm_.
Dueser, Ed, and Jeff Heaton. “Affordable Access to Quantum Computing Opens the Door to Experimentation, Potential Security Threats .” Default, May 2023, www.rgare.com/knowledge-center/article/affordable-access-to-quantum-computing-opens-the-door-to-experimentation-potential-security-threats.
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