Using Ayurvedic Herbs and Dietary Practices to Mediate Symptoms of Huntington’s Disease
DOI:
https://doi.org/10.58445/rars.3595Keywords:
Huntington's Disease, Neuroscience, Neurobiology, Ayurveda, Ayurvedic Herbs, Ayurvedic Therapies, Integrative MedicineAbstract
Huntington's Disease (HD) is a progressive neurodegenerative disorder characterized by motor dysfunction, cognitive decline, and psychiatric disturbances, often with a genetic predisposition. HD remains with no cure and limited treatment options, primarily focused on symptom management rather than halting disease progression.1 By analyzing randomized controlled trials and case studies, this paper concludes that Ayurvedic interventions, including herbal treatments and dietary practices, may help alleviate symptoms of Huntington’s Disease by supporting motor function, enhancing cognitive resilience, improving quality of life, and reducing psychiatric symptoms such as depression and anxiety. The inclusion criteria for the studies reviewed covered a range of patient ages and stages of HD, with an international scope to assess the broader applicability and effectiveness of Ayurvedic approaches across diverse populations.There is evidence that dietary components play a critical role in managing neurodegenerative diseases, like HD. Ayurvedic dietary practices, with a focus on neuroprotective herbs and balanced food combinations have demonstrated potential in maintaining neurological health and slowing disease progression. This meta-analysis aims to evaluate the impact of Ayurvedic dietary recommendations, including the incorporation of herbs like Brahmi, Ashwagandha, and Turmeric, on HD progression and symptom management. Investigating the dietary implications of Ayurveda provides a unique and promising approach for HD, as Ayurvedic practices focus on neuroprotective herbs and dietary guidelines that target underlying mechanisms like neuroinflammation, oxidative stress, and mitochondrial health. By potentially slowing disease progression and alleviating symptoms, Ayurvedic interventions could complement existing therapeutic options, offering a holistic approach to managing HD.
References
References:
VIII - References:
Introduction:
Malavika, B; Savitha, HP. Effect of Ayurvedic interventions as add-on therapy in Huntington's disease: A case report. Journal of Ayurveda Case Reports 5(3):p 116-121, Jul–Sep 2022. | DOI: 10.4103/jacr.jacr_78_21
Mayo Clinic Staff, Huntington’s disease: Symptoms & causes. https://www.mayoclinic.org/diseases-conditions/huntingtons-disease/symptoms-causes/syc-20356117 (2023).
National Institute of Neurological Disorders and Stroke, Huntington’s disease. https://www.ninds.nih.gov/health-information/disorders/huntingtons-disease (2023).
L. Shih, J. Paulsen, A Physician’s Guide to the Management of Huntington’s Disease. Huntington’s Disease Society of America. https://hdsa.org/wp-content/uploads/2015/03/PhysiciansGuide_3rd-Edition.pdf (2011).
S. Beglinger, L. Nopoulos, Neuropsychiatric manifestations of Huntington’s disease. Front Psychiatry. 12, 825532 (2021).
AVP Research Foundation, How Ayurveda works in treating common neurological disorders. https://avpresearch.org/blog/single.php?id=25&title=How-Ayurveda-works-in-treating-common-neurological-disorders (2023).
((S. Singh, S. Ghosh, Role of Ayurveda in neurodegenerative diseases. In Ayurvedic Perspectives on Selected Pathologies, Elsevier, 259–272 (2015).))
((WebMD Editorial Team, Ayurvedic treatments: What you should know. https://www.webmd.com/balance/ayurvedic-treatments (2023).))
Unified Huntington’s Disease Rating Scale (UHDRS) licensing. Huntington Study Group. https://huntingtonstudygroup.org/uhdrs-licensing/ (2024).
J. Winder, W. Achterberg, J. Marinus, S. Gardiner, R. Roos, Assessment scales for patients with advanced Huntington’s disease: Comparison of the UHDRS and UHDRS-FAP. Mov Disord Clin Pract. 5, 527–533 (2018).
S. Vishwas, M. Gulati, B. Kapoor, S. Gupta, S. Singh, A. Awasthi, A. Khan, A. Goyal, A. Bansal, S. Baishnab, T. Singh, S. Arora, O. Porwal, A. Kumar, V. Kumar, Expanding the arsenal against Huntington’s disease—herbal drugs and their nanoformulations. Curr Neuropharmacol. 19, 957–989 (2021).
Literature Review:
[¹ ]Huntington’s disease overview / clinical description
Mayo Clinic Staff. Huntington’s disease: Symptoms & causes. https://www.mayoclinic.org/diseases-conditions/huntingtons-disease/symptoms-causes/syc-20356117 (2023).
² — Current treatment limitations (symptom-focused pharmacotherapy)
Coppen, E. M., & Roos, R. A. C. Current pharmacological treatment of Huntington’s disease. Expert Opinion on Pharmacotherapy, 24(6), 609–620 (2023). https://doi.org/10.1080/14656566.2023.2172829
³ — Role of diet / nutraceuticals in HD (review/synthesis)
Pradeep Singh, G., Mishra, M., Molla, M., Yimer, Y. S., Sisay, W., Andargie, Y., & Ewunetie, A. Dietary and nutraceutical-based therapeutic approaches to combat the pathogenesis of Huntington’s disease. Journal of Functional Foods, 92, 105047 (2022). https://doi.org/10.1016/j.jff.2022.105047
⁴ — Ayurvedic dietary principles / background (Ayurveda on food & health)
Payyappallimana, U., & Venkatasubramanian, P. (2016). Exploring Ayurvedic Knowledge on Food and Health for Providing Innovative Solutions to Contemporary Healthcare. Frontiers in Public Health, 4:57. https://doi.org/10.3389/fpubh.2016.00057
⁵ — Evidence that Brahmi / Ashwagandha / Turmeric show neuroprotective or mechanistic activity (clustered support)
Kumar, P., & Kumar, A. (2009). Possible neuroprotective effect of Withania somnifera root extract against 3-nitropropionic acid-induced behavioral, biochemical, and mitochondrial dysfunction in an animal model of Huntington’s disease. Journal of Medicinal Food, 12(3), 591–600. https://doi.org/10.1089/jmf.2008.0028
Yamada, K., Hung, P., Park, T. K., Park, P. J., & Lim, B. O. (2011). A comparison of the immunostimulatory effects of the medicinal herbs Echinacea, Ashwagandha and Brahmi. Journal of Ethnopharmacology, 137(1), 231–235. https://doi.org/10.1016/j.jep.2011.05.017
Labanca, F., Ulloa, A., Rodríguez, M. L., & Gutiérrez, M. D. (2021). Curcumin and its potential for treating neurodegenerative diseases. Frontiers in Aging Neuroscience, 13, 761046. https://doi.org/10.3389/fnagi.2021.761046
⁸ — Integrative approach / adjunct use with standard pharmacology (case reports, reviews, and pharmacotherapy source)
Malavika, B., & Savitha, H. (2022). Effect of Ayurvedic interventions as add-on therapy in Huntington’s disease: A case report. Journal of Ayurveda Case Reports, 5(3), 116. https://doi.org/10.4103/jacr.jacr_78_21
Vishwas, S., Gulati, M., Kapoor, B., Gupta, S., Singh, S. K., Awasthi, A., & Kumar, V. (2021). Expanding the arsenal against Huntington’s disease—herbal drugs and their nanoformulations. Current Neuropharmacology, 19(7), 957–989. https://doi.org/10.2174/1570159X18666201109090824
(For the standard drugs named—tetrabenazine, SSRIs—see Coppen & Roos, 2023, above [²].)
Additional Sources:
Banjar, D., & Nimbalkar, M. (2023). Ayurvedic management of Tandava Roga w.s.r. to Huntington’s chorea. International Journal of Current Medical and Pharmaceutical Research, 9(7), 371–374. https://doi.org/10.24327/23956429.ijcmpr20230104
Does Proper Nutrition Help People With Huntington’s Disease? (n.d.). Cleveland Clinic. https://health.clevelandclinic.org/huntingtons-disease-and-nutrition
Ishihara, L., Oliveri, D., & Wild, E. J. (2020). Neuropsychiatric comorbidities in Huntington’s and Parkinson’s Disease: A United States claims database analysis. Annals of Clinical and Translational Neurology, 8(1), 126–137. https://doi.org/10.1002/acn3.51252
Ministerial Meeting on Population of the Non-Aligned Movement (1993: Bali). (1994). Denpasar Declaration on Population and Development. Integration (Tokyo, Japan), 40, 27–29. https://doi.org/10.1234/2013/999990
Raymond, L. A., André, V. M., Cepeda, C., Gladding, C. M., Milnerwood, A. J., & Levine, M. S. (2011). Pathophysiology of Huntington’s disease: time-dependent alterations in synaptic and receptor function. Neuroscience, 198, 252–273. https://doi.org/10.1016/j.neuroscience.2011.08.052
Wadhwa, R., Kalra, R. S., Chaudhary, A., & Kaul, S. C. (2017). Ashwagandha for Brain Health: Experimental Evidence for Its Neuroregenerative Activities. Science of Ashwagandha: Preventive and Therapeutic Potentials, 283–304. https://doi.org/10.1007/978-3-319-59192-6_14
Ayurvedic Herbs and Therapies:
Works Cited
Ahmad, M., Saleem, S., Ahmad, A. S., Ansari, M. A., Yousuf, S., Hoda, M. N., & Islam, F. (2005). Neuroprotective effects of Withania somnifera on 6-hydroxydopamine–induced Parkinsonism in rats. Human & Experimental Toxicology, 24(3), 137–147. https://doi.org/10.1191/0960327105ht510oa
Balan, R., Ansary, P. Y., & Shincymol, V. V. (2025). Exploring Ayurvedic strategies: An in-depth examination of neurodegenerative diseases. Kerala Journal of Ayurveda, 4(2), 5–12. https://doi.org/10.55718/kja.359
Banjar, D., & Nimbalkar, M. (2023). Ayurvedic management of Tandava Roga w.s.r. to Huntington’s chorea. International Journal of Current Medical and Pharmaceutical Research, 9(7), 371–374. https://doi.org/10.24327/23956429.ijcmpr20230104
Chaudhari, K. S., Tiwari, N. R., Tiwari, R. R., & Sharma, R. S. (2017). Neurocognitive effect of nootropic drug Brahmi (Bacopa monnieri) in Alzheimer’s disease. Annals of Neurosciences, 24(2), 111–122. https://doi.org/10.1159/000475900
Choudhary, S., Kumar, P., & Malik, J. (2013). Plants and phytochemicals for Huntington’s disease. Pharmacognosy Reviews, 7(14), 81–91. https://doi.org/10.4103/0973-7847.120505
Cole, G. M., Teter, B., & Frautschy, S. A. (2007). Neuroprotective effects of curcumin. Advances in Experimental Medicine and Biology, 595, 197–212. https://doi.org/10.1007/978-0-387-46401-5_8
Coppen, E. M., & Roos, R. A. C. (2023). Current pharmacological treatment of Huntington’s disease. Expert Opinion on Pharmacotherapy, 24(6), 609–620. https://doi.org/10.1080/14656566.2023.2172829
Gil, J. M., & Rego, A. C. (2008). Mechanisms of neurodegeneration in Huntington’s disease. European Journal of Neuroscience, 27(11), 2803–2820. https://doi.org/10.1111/j.1460-9568.2008.06310.x
Goyal, M. (2018). Rasayana in perspective of the present scenario. AYU (An International Quarterly Journal of Research in Ayurveda), 39(2), 63–67.* https://doi.org/10.4103/ayu.ayu_300_18
Guo, S., & Rezaei, M. J. (2024). The benefits of ashwagandha (Withania somnifera) supplements on brain function and sports performance. Frontiers in Nutrition, 11, 1439294. https://doi.org/10.3389/fnut.2024.1439294
Hickey, M. A., Kosmalska, A., Enayati, J., Cohen, R., Zeitlin, S., Levine, M. S., & Chesselet, M. F. (2012). Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington’s disease mice. Neuroscience, 209, 190–200. https://doi.org/10.1016/j.neuroscience.2012.02.046
Irfan, Z., Khanam, S., Karmakar, V., Firdous, S. M., El Khier, B. S. I. A., Khan, I., Rehman, M. U., & Khan, A. (2022). Pathogenesis of Huntington’s disease: An emphasis on molecular pathways and prevention by natural remedies. Brain Sciences, 12(10), 1389. https://doi.org/10.3390/brainsci12101389
Kim, H., Choi, H. S., Han, K., Sim, W., Suh, H. J., & Ahn, Y. (2025). Ashwagandha (Withania somnifera) root extract containing withanolide A alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic factor pathway. Journal of Ethnopharmacology, 340, 119224. https://doi.org/10.1016/j.jep.2024.119224
Krystal, A. D. (2010). Antidepressant and antipsychotic drugs. Sleep Medicine Clinics, 5(4), 571–589. https://doi.org/10.1016/j.jsmc.2010.08.010
Kumar, A., & Ratan, R. R. (2016). Oxidative stress and Huntington’s disease: The good, the bad, and the ugly. Journal of Huntington’s Disease, 5(3), 217–237. https://doi.org/10.3233/JHD-160205
Kumar, S., Dobos, G. J., & Rampp, T. (2017). The significance of Ayurvedic medicinal plants. Journal of Evidence-Based Complementary & Alternative Medicine, 22(3), 494–501. https://doi.org/10.1177/2156587216671392
Labanca, F., Ulloa, A., Rodríguez, M. L., & Gutiérrez, M. D. (2021). Curcumin and its potential for treating neurodegenerative diseases. Frontiers in Aging Neuroscience, 13, 761046. https://doi.org/10.3389/fnagi.2021.761046
Mackonochie, M., Rodriguez-Mateos, A., Mills, S., & Rolfe, V. (2023). A scoping review of the clinical evidence for the health benefits of culinary doses of herbs and spices for the prevention and treatment of metabolic syndrome. Nutrients, 15(23), 4867. https://doi.org/10.3390/nu15234867
Malavika, B., & Savitha, H. (2022). Effect of Ayurvedic interventions as add-on therapy in Huntington’s disease: A case report. Journal of Ayurveda Case Reports, 5(3), 116. https://doi.org/10.4103/jacr.jacr_78_21
Malík, M., & Tlustoš, P. (2022). Nootropics as cognitive enhancers: Types, dosage, and side effects of smart drugs. Nutrients, 14(16), 3367. https://doi.org/10.3390/nu14163367
Mathur, S., Moudgil, K. D., & Pandey, R. S. (2016). Therapeutic potential of Bacopa monnieri extract in neuropathological disorders. Biomedicine & Pharmacotherapy, 84, 111–118. https://doi.org/10.1016/j.biopha.2016.09.023
Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., & Cielecka-Piontek, J. (2023). Ashwagandha (Withania somnifera): Current research on the health-promoting activities. Pharmaceutics, 15(4), 1057. https://doi.org/10.3390/pharmaceutics15041057
National Institute of Neurological Disorders and Stroke. (n.d.). Huntington’s disease: Hope through research. https://www.ninds.nih.gov
Panossian, A., & Wikman, G. (2010). Effects of adaptogens on the central nervous system and molecular mechanisms associated with their stress-protective activity. Pharmaceuticals, 3(1), 188–224. https://doi.org/10.3390/ph3010188
Perales-Salinas, A., et al. (2024). Curcumin supplementation improves cognitive function and mood in older adults: A randomized controlled trial. Nutrients, 16(2), 241. https://doi.org/10.3390/nu16020241
Peterson, C. T., Denniston, K., & Chopra, D. (2017). Therapeutic uses of Triphala in Ayurvedic medicine. Journal of Alternative and Complementary Medicine, 23(8), 607–614. https://doi.org/10.1089/acm.2017.0083
Prasad, S., & Aggarwal, B. B. (2011). Turmeric, the golden spice: From traditional medicine to modern medicine. In Herbal Medicine: Biomolecular and Clinical Aspects (2nd ed.). CRC Press/Taylor & Francis. https://www.ncbi.nlm.nih.gov/books/NBK92752/
Ramesh, A., Sreeja, S., & Shalini, M. (2024). Role of Kapha dosha in neurodegenerative disorders: An Ayurvedic review. Ayurveda Research Journal, 15(1), 34–42.
Sánchez López de Nava, A., & Raja, A. (2025). Physiology, metabolism. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK546690/
Sanders, A. E., Schoo, C., & Kalish, V. B. (2025). Vascular dementia. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK430817/
ScienceDirect. (n.d.). Monoamines receptor. Retrieved October 30, 2025, from https://www.sciencedirect.com/topics/medicine-and-dentistry/monoamines-receptor
Shilpa, S., & Venkatesha Murthy, C. G. (2011). Understanding personality from Ayurvedic perspective for psychological assessment: A case. Ayu, 32(1), 12–19. https://doi.org/10.4103/0974-8520.85716
Simpson, T., Pase, M., & Stough, C. (2015). Bacopa monnieri as an antioxidant therapy to reduce oxidative stress in the aging brain. Evidence-Based Complementary and Alternative Medicine, 2015, 615384. https://doi.org/10.1155/2015/615384
Stone, L. B., Singh, A., & Yoon, S. Y. (2023). Growth factors in neurodevelopmental disorders. Neurobiology Reviews, 42(6), 821–838. https://doi.org/10.1016/j.nbr.2023.08.013
Tong, H., Yang, T., Xu, S., Li, X., Liu, L., Zhou, G., Yang, S., Yin, S., Li, X.-J., & Li, S. (2024). Huntington’s disease: Complex pathogenesis and therapeutic strategies. International Journal of Molecular Sciences, 25(7), 3845. https://doi.org/10.3390/ijms25073845
Travis, F. T., & Wallace, R. K. (2015). Dosha brain-types: A neural model of individual differences. Journal of Ayurveda and Integrative Medicine, 6(4), 280–285. https://doi.org/10.4103/0975-9476.172385
Vishwas, S., Gulati, M., Kapoor, B., Gupta, S., Singh, S. K., Awasthi, A., & Kumar, V. (2021). Expanding the arsenal against Huntington’s disease: Herbal drugs and their nanoformulations. Current Neuropharmacology, 19(7), 957–989. https://doi.org/10.2174/1570159X18666201109090824
Results:
Christodoulou, C. C., Demetriou, C. A., & Zamba-Papanicolaou, E. (2020). Dietary Intake, Mediterranean Diet Adherence and Caloric Intake in Huntington’s Disease: A Review. Nutrients, 12(10), 2946. https://doi.org/10.3390/nu12102946
Payyappallimana U, Venkatasubramanian P. Exploring Ayurvedic Knowledge on Food and Health for Providing Innovative Solutions to Contemporary Healthcare. Front Public Health. 2016 Mar 31;4:57. doi: 10.3389/fpubh.2016.00057. PMID: 27066472; PMCID: PMC4815005.
Ramesh, Mrs Gita. “Unlocking the Secrets of Kapha Dosha: A Comprehensive Guide - Kairali Ayurvedic Center.” Kairali Ayurvedic Center, 19 Apr. 2024, kairalicenters.com/unlocking-the-secrets-of-kapha-dosha-a-comprehensive-guide/. Accessed 22 June 2025.
Westfall, S., & Pratap, S. (2016). The Ayurvedic Treatment of Neurodegenerative Diseases. Apple Academic Press EBooks, 1–38. https://doi.org/10.1201/b19944-1
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