The Dose Makes the Cure
Harnessing the Therapeutic Potential of Peruvian Snake Venoms
DOI:
https://doi.org/10.58445/rars.3550Keywords:
Snake venom biochemistry, Venom-derived bioactive molecules, Natural toxins in biomedical research, Venom-based therapeutics, Animal venoms as drug leadsAbstract
For decades, snake venom has been studied for its diverse array of biological properties. From the isolation of various biomolecules, it has been possible to obtain resources for the development of therapeutic tools for a wide variety of medical conditions. This work compiles findings from multiple studies conducted on the subject, focusing specifically on the biomolecules from the four genera of venomous snakes found in Peru—Bothrops, Crotalus, Lachesis, and Micrurus—to highlight their importance as resources for biotechnological research. It presents information on metalloproteases, disintegrins, phospholipases A2, L-amino acid oxidases, serine proteases, and other biomolecules isolated from different species of these genera, describing their characteristics and potential applications in the development of therapeutic tools to treat a wide range of ailments, such as microbial and viral infections, various types of pain, and cancer, among others. Lastly, it briefly outlines several suggestions for the conservation and protection of these species, in hopes of expressing gratitude toward the natural sources that provide these valuable resources.
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