Preprint / Version 1

Studying the role of the tumor’ microenvironment on cancer progression.

##article.authors##

  • George Zhang Sunnyvale High School
  • Carie Stanfill Sunnyvale High School

DOI:

https://doi.org/10.58445/rars.336

Keywords:

cancer research, cancer biology, metastasis, tumor microenvironment, cancer progression, cancer, high school research

Abstract

This research paper delves into the crucial significance of the tumor microenvironment in cancer progression and treatment resistance. Focusing on tumor angiogenesis, immune cell interactions, and extracellular matrix modifications, the study highlights the need to comprehend the complex dynamics within the tumor microenvironment. Targeting these interactions presents promising avenues for developing effective cancer therapies. Disrupting angiogenesis, overcoming immune suppression, and addressing ECM alterations emerge as potential strategies to improve treatment outcomes. The research emphasizes the importance of exploring the tumor microenvironment to advance our understanding and pave the way for transformative cancer treatments in the future.

References

Richard. (2016, September 14). Angiogenesis of tumors, its history. Retrieved 11 August 2023, from Seagate World | A look into the human side of Seagate website: https://www.seagateworld.com/2016/09/angiogenesis-of-tumors/.

Anderson, N. M., & Simon, M. C. (2020). The tumor microenvironment. Current Biology: CB, 30(16), R921–R925. doi:10.1016/j.cub.2020.06.081

Huang, J., Zhang, L., Wan, D., Zhou, L., Zheng, S., Lin, S., & Qiao, Y. (2021). Extracellular matrix and its therapeutic potential for cancer treatment. Signal Transduction and Targeted Therapy, 6(1), 153. doi:10.1038/s41392-021-00544-0

Extracellular matrix. (2017, September 8). Retrieved 11 August 2023, from Biology Dictionary website: https://biologydictionary.net/extracellular-matrix/.

Gupta, M. K., & Qin, R.-Y. (2003). Mechanism and its regulation of tumor-induced angiogenesis. World Journal of Gastroenterology: WJG, 9(6), 1144–1155. doi:10.3748/wjg.v9.i6.1144

Greten, F. R., & Grivennikov, S. I. (2019). Inflammation and cancer: Triggers, mechanisms, and consequences. Immunity, 51(1), 27–41. doi:10.1016/j.immuni.2019.06.025

Sharpe, M., & Mount, N. (2015). Genetically modified T cells in cancer therapy: opportunities and challenges. Disease Models & Mechanisms, 8(4), 337–350. doi:10.1242/dmm.018036

Singh, Yogendra. “(PDF) Tumor Angiogenesis: Clinical Implications.” ResearchGate, https://www.researchgate.net/publication/282782201_Tumor_Angiogenesis_Clinical_Implications.

Pan, Y., Yu, Y., Wang, X., & Zhang, T. (2020). Tumor-associated macrophages in tumor immunity. Frontiers in Immunology, 11, 583084. doi:10.3389/fimmu.2020.583084

Zhou, J., & Shi, Y. (2023). Mesenchymal stem/stromal cells (MSCs): origin, immune regulation, and clinical applications. Cellular & Molecular Immunology, 20(6), 555–557. doi:10.1038/s41423-023-01034-9

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Posted

2023-08-24