Exploring the Antibacterial Potential and Phytochemical Composition of Five Indigenous Indian Medicinal Plants Effective Strategies Against Multi-Drug Resistant and ESKAPE Pathogens (1)
DOI:
https://doi.org/10.58445/rars.334Abstract
This paper presents the findings of a secondary research study conducted to investigate the antibacterial potential and phytochemical composition of four indigenous Indian medicinal plants, namely Salvadora persica (Miswak), Caesalpinia pulcherrima (Peacock flower), Thymus vulgaris (Thyme), and Saussurea lappa (Kuth). The study aimed to explore the efficacy of these plants against multi-drug resistant and ESKAPE pathogens, which pose a significant threat to public health. A comprehensive review of scientific literature was conducted to gather relevant information on the antimicrobial properties and phytochemical constituents of the selected plants. The antibacterial activity of the plant extracts was evaluated against a panel of multi-drug resistant bacteria and ESKAPE pathogens, including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species. The results revealed that all four medicinal plants exhibited notable antibacterial activity against the tested pathogens. Salvadora persica demonstrated potent activity against Enterococcus faecium and Staphylococcus aureus, while Caesalpinia pulcherrima displayed significant activity against Klebsiella pneumoniae and Acinetobacter baumannii. Thymus vulgaris exhibited broad-spectrum activity against multiple pathogens, including Pseudomonas aeruginosa and Enterobacter species. Saussurea lappa also demonstrated promising antibacterial effects against various ESKAPE pathogens. Furthermore, the phytochemical analysis of the plant extracts revealed the presence of several bioactive compounds, such as alkaloids, flavonoids, phenolic compounds, and terpenoids, which are known for their antimicrobial properties. These compounds likely contribute to the observed antibacterial activity of medicinal plants.
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