Oncogene Addiction: How Cancer Cells Can Become So Aggressive
DOI:
https://doi.org/10.58445/rars.3188Keywords:
bone cancer, cancer, bone, oncogenes, tumor supressor, genesAbstract
Bone cancer is an aggressive, yet rare form of cancer that makes up less than 1% of all people who are diagnosed with cancer. Patients with bone cancer face significant challenges when it comes to cancer diagnosis and treatment due to the tumor’s rich microenvironment and heterogeneity. This review provides a comprehensive overview of bone cancer, starting with foundational mechanisms like DNA replication and the cell cycle, detailing how specific genes like tumor suppressors and oncogenes create errors and dysregulation in these processes, aiding in the formation of malignant tumors. With 500,000 people battling this complex cancer, it is important to understand the mechanisms of how it can form and metastasis in order to figure out new ways of diagnosing and treating patients more effectively.
References
Sources:
Cancer statistics. National Cancer Institute. (2025, May 7). https://www.cancer.gov/about-cancer/understanding/statistics
What is cancer?. NCI. (2021, October 11). https://www.cancer.gov/about-cancer/understanding/what-is-cancer#the-definition-of-cancer
American Cancer Society. (2025, January 16). Key statistics about bone cancer: Bone Cancer Statistics. Bone Cancer Statistics | American Cancer Society. https://www.cancer.org/cancer/types/bone-cancer/about/key-statistics.html
American Cancer Society. (2021, June 17). Understanding bone cancer. Understanding Bone Cancer | American Cancer Society. https://www.cancer.org/cancer/types/bone-cancer/about/what-is-bone-cancer.html
American Cancer Society. (2021, June 17). Bone cancer early detection, diagnosis, and staging. American Cancer Society. https://www.cancer.org/cancer/types/bone-cancer/detection-diagnosis-staging.html
Cooper GM. The Cell: A Molecular Approach. 2nd edition. Sunderland (MA): Sinauer Associates; 2000. DNA Replication. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9940/
The unzipping enzyme: Protein Data Bank in Europe. The unzipping enzyme | Protein Data Bank in Europe. (2021, May 1). https://www.ebi.ac.uk/pdbe/articles/unzipping-enzyme#:~:text=In%20general%2C%20bacterial%20helicases%20translocate,between%20bacterial%20and%20eukaryotic%20helicase.
Libretexts. (2022, July 30). 7.4: Cell Cycle Checkpoints. Biology LibreTexts. https://bio.libretexts.org/Courses/Lumen_Learning/Biology_for_Non-Majors_I_(Lumen)/07%3A_Cell_Division/7.04%3A_Cell_Cycle_Checkpoints
Cooper GM. The Cell: A Molecular Approach. 2nd edition. Sunderland (MA): Sinauer Associates; 2000. The Events of M Phase. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9958/
:Bone cancer causes, risk factors, and prevention. American Cancer Society. (2021c, June 17). https://www.cancer.org/cancer/types/bone-cancer/causes-risks-prevention.html
OpenStax College. (n.d.). Molecular mechanisms of DNA Replication . Khan Academy. https://www.khanacademy.org/science/ap-biology/gene-expression-and-regulation/replication/a/molecular-mechanism-of-dna-replication
Matthews, H. K., Bertoli, C., & de Bruin, R. A. M. (2021, September 10). Cell cycle control in cancer. Nature News. https://www.nature.com/articles/s41580-021-00404-3
National Center for Biotechnology Information (US). Genes and Disease [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 1998-. The p53 tumor suppressor protein. Available from: https://www.ncbi.nlm.nih.gov/books/NBK22268/
U.S. National Library of Medicine. (2009, April 1). RB1 gene: Medlineplus genetics. MedlinePlus. https://medlineplus.gov/genetics/gene/rb1/
Tumor suppressor gene. Genome.gov. (2025, July 29). https://www.genome.gov/genetics-glossary/Tumor-Suppressor-Gene
Satyanarayana, A., Kaldis, P. A dual role of Cdk2 in DNA damage response. Cell Div 4, 9 (2009). https://doi.org/10.1186/1747-1028-4-9
Murfin, K. (2021, April 6). 3 things to know about the tumor microenvironment. MD Anderson Cancer Center. https://www.mdanderson.org/cancerwise/what-is-the-tumor-microenvironment-3-things-to-know.h00-159460056.html
Buenrostro D, Mulcrone PL, Owens P, Sterling JA. The Bone Microenvironment: a Fertile Soil for Tumor Growth. Curr Osteoporos Rep. 2016 Aug;14(4):151-8. doi: 10.1007/s11914-016-0315-2. PMID: 27255469; PMCID: PMC4927340.
Mayo Foundation for Medical Education and Research. (2025, June 11). Bone metastasis. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/bone-metastasis/symptoms-causes/syc-20370191
U.S. Department of Health and Human Services. (2025, July). Computed Tomography (CT). National Institute of Biomedical Imaging and Bioengineering. https://www.nibib.nih.gov/science-education/science-topics/computed-tomography-ct
Bone biopsy. Johns Hopkins Medicine. (2021, August 8). https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/bone-biopsy
Mayo Foundation for Medical Education and Research. (2024, March 13). Chemotherapy. Mayo Clinic. https://www.mayoclinic.org/tests-procedures/chemotherapy/about/pac-20385033
Mayo Foundation for Medical Education and Research. (2024b, July 2). Radiation therapy. Mayo Clinic. https://www.mayoclinic.org/tests-procedures/radiation-therapy/about/pac-20385162
Garcia-Ortega DY, Cabrera-Nieto SA, Caro-Sánchez HS, Cruz-Ramos M. An overview of resistance to chemotherapy in osteosarcoma and future perspectives. Cancer Drug Resist. 2022 Jun 23;5(3):762-793. doi: 10.20517/cdr.2022.18. PMID: 36176756; PMCID: PMC9511812.
Zacharia B, Joy J, Subramaniam D, Pai PK. Factors Affecting Life Expectancy After Bone Metastasis in Adults - Results of a 5-year Prospective Study. Indian J Surg Oncol. 2021 Dec;12(4):759-769. doi: 10.1007/s13193-021-01426-1. Epub 2021 Aug 30. PMID: 35110900; PMCID: PMC8764008.
Smrke A, Anderson PM, Gulia A, Gennatas S, Huang PH, Jones RL. Future Directions in the Treatment of Osteosarcoma. Cells. 2021 Jan 15;10(1):172. doi: 10.3390/cells10010172. PMID: 33467756; PMCID: PMC7829872.
Guan, Y., Zhang, W., Mao, Y. et al. Nanoparticles and bone microenvironment: a comprehensive review for malignant bone tumor diagnosis and treatment. Mol Cancer 23, 246 (2024). https://doi.org/10.1186/s12943-024-02161-1
Sun J, Xing F, Braun J, Traub F, Rommens PM, Xiang Z, Ritz U. Progress of Phototherapy Applications in the Treatment of Bone Cancer. Int J Mol Sci. 2021 Oct 21;22(21):11354. doi: 10.3390/ijms222111354. PMID: 34768789; PMCID: PMC8584114.
Todd A. Gould, R.-(R)(MR)(ARRT), & Edmonds, M. (2023, June 9). How MRI works. HowStuffWorks Science. https://science.howstuffworks.com/mri.htm
Canadian Cancer Society / Société canadienne du cancer. (2024, November). Chemotherapy for Bone Cancer. Canadian Cancer Society. https://cancer.ca/en/cancer-information/cancer-types/bone/treatment/chemotherapy
Buchbinder EI, Desai A. CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition. Am J Clin Oncol. 2016 Feb;39(1):98-106. doi: 10.1097/COC.0000000000000239. PMID: 26558876; PMCID: PMC4892769.
Home. (2025, February). https://www.explorecelltherapy.com/?cid=sem_3192009&gad_source=1&gad_campaignid=22515963570&gbraid=0AAAAA-gAQXQ_t9addYMIclX4b4Qsji4sd&gclid=EAIaIQobChMIiJu68tHFjgMVXihECB1a3iSaEAAYASAAEgK3wfD_BwE&gclsrc=aw.ds
Phi LTH, Sari IN, Yang YG, Lee SH, Jun N, Kim KS, Lee YK, Kwon HY. Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment. Stem Cells Int. 2018 Feb 28;2018:5416923. doi: 10.1155/2018/5416923. PMID: 29681949; PMCID: PMC5850899.
Moore, L., Le, T. & Fan, G. DNA Methylation and Its Basic Function. Neuropsychopharmacol 38, 23–38 (2013). https://doi.org/10.1038/npp.2012.112
Histone modifications. Abcam. (2025). https://www.abcam.com/en-us/technical-resources/guides/epigenetics-guide/histone-modifications?srsltid=AfmBOooObnOrLESvLiTyy763ulewpRjD0GYiLcUnam5vVk947Cw3tojI
Wei JW, Huang K, Yang C, Kang CS. Non-coding RNAs as regulators in epigenetics (Review). Oncol Rep. 2017 Jan;37(1):3-9. doi: 10.3892/or.2016.5236. Epub 2016 Nov 8. PMID: 27841002.
Song, J., Yang, P., Chen, C. et al. Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance. Sig Transduct Target Ther 10, 219 (2025). https://doi.org/10.1038/s41392-025-02266-z
Huang JF, Shen J, Li X, Rengan R, Silvestris N, Wang M, Derosa L, Zheng X, Belli A, Zhang XL, Li YM, Wu A. Incidence of patients with bone metastases at diagnosis of solid tumors in adults: a large population-based study. Ann Transl Med. 2020 Apr;8(7):482. doi: 10.21037/atm.2020.03.55. PMID: 32395526; PMCID: PMC7210217.
Singh, A., Settleman, J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 29, 4741–4751 (2010). https://doi.org/10.1038/onc.2010.215
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