Neuropsychiatric Associations of Mast Cell Activiation Syndrome and its Implications with Mental Health and Depression

Abstract

Abstract–Mast Cell Activation Syndrome (MCAS) is an underrecognized immunological disorder characterized by aberrant release of mast cell mediators affecting multiple organ systems. Beyond physical manifestations, patients frequently report psychiatric comorbidities including depression, anxiety, and cognitive impairment. This study reviews patient-reported outcomes, existing survey data, and published literature to explore the relationship between MCAS and mental health. Results indicate that elevated rates of depression and anxiety among MCAS patients may stem from both biological mechanisms—such as mast cell–derived cytokine release and histamine dysregulation—and psychosocial factors, including prolonged diagnostic uncertainty and chronic symptom burden. Evidence suggests that targeting mast cell activity may provide symptomatic relief beyond physical health, underscoring the need for interdisciplinary management that integrates psychiatry and immunology. Greater recognition of these neuropsychiatric dimensions could improve patient outcomes and guide future therapeutic strategies.