Preprint / Version 1

Effects of Urban Noise Pollution on the Brain

##article.authors##

  • Anya Verma Student

DOI:

https://doi.org/10.58445/rars.2739

Keywords:

Urban noise pollution, Environmental stressors

Abstract

Urban noise pollution is characterized by the sounds of sirens, cars, trains, and other traffic. It can be a nuisance to the average person during their commute. Noise pollution is a prevalent environmental issue that contributes to the suffering of millions of people globally (United Nations Environment Programme, 2020; Soundproof Cow, 2017). Several diseases and negative mental states have been linked to excessive noise, such as cardiovascular disease and increased annoyance (Münzel et al., 2018; Jafari et al., 2019). However, while the physical effects of noise have been investigated thoroughly, the biochemical effects are yet to be studied.

The first specific aim of this study is to analyze the chemical changes in the brain in response to varying amplitudes of noise. It is known that noise increases variability in neurotransmitter release (Faisal et al., 2008). Additionally, response to noise results in an increase in the stress hormone cortisol (Spreng, 2000).

The second specific aim of this study is to determine what chronic noise exposure does to oxidative stress in the brain. Specifically, it aims to determine whether levels of oxidative stress vary as the time of exposure increases, or remains the same during the whole period, including during levels after exposure has concluded.

The third specific aim of this study is to analyze what happens to the rate of hippocampal neurogenesis during exposure to chronic noise. It has been established that noise exposure negatively affects visual and auditory attention span (Jafari et al., 2019). This study will analyze the amount of mature and proliferating neurons in the hippocampus to identify specific patterns. 

 

References

Babcock, K. R., Page, J. S., Fallon, J. R., & Webb, A. E. (2021). Adult Hippocampal Neurogenesis in Aging and Alzheimer’s Disease. Stem Cell Reports, 16(4), 681–693. https://doi.org/10.1016/j.stemcr.2021.01.019

Bai, L., Shin, S., Oiamo, T. H., Burnett, R. T., Weichenthal, S., Jerrett, M., Kwong, J. C., Copes, R., Kopp, A., & Chen, H. (2020). Exposure to Road Traffic Noise and Incidence of Acute Myocardial Infarction and Congestive Heart Failure: A Population-Based Cohort Study in Toronto, Canada. Environmental Health Perspectives, 128(8), 087001. https://doi.org/10.1289/ehp5809

Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998). Neurogenesis in the adult human hippocampus. Nature Medicine, 4(11), 1313–1317. https://doi.org/10.1038/3305

Faisal, A. A., Selen, L. P. J., & Wolpert, D. M. (2008). Noise in the nervous system. Nature Reviews Neuroscience, 9(4), 292–303. https://doi.org/10.1038/nrn2258

Gaweł, S., Wardas, M., Niedworok, E., & Wardas, P. (2004). [Malondialdehyde (MDA) as a lipid peroxidation marker]. Wiadomosci Lekarskie (Warsaw, Poland: 1960), 57(9-10), 453–455. https://pubmed.ncbi.nlm.nih.gov/15765761/#:~:text=Malondialdehyde%20(MDA)%20is%20one%20of

Gemma, C., Vila, J., Bachstetter, A., & Bickford, P. C. (2013). Oxidative Stress and the Aging Brain: From Theory to Prevention. Nih.gov; CRC Press/Taylor & Francis. https://www.ncbi.nlm.nih.gov/books/NBK3869/

Grońska-Pęski, M., Gonçalves, J. T., & Hébert, J. M. (2021). Enriched Environment Promotes Adult Hippocampal Neurogenesis through FGFRs. The Journal of Neuroscience, 41(13), 2899–2910. https://doi.org/10.1523/jneurosci.2286-20.2021

Gusel’nikova, V. V., & Korzhevskiy, D. E. (2015). NeuN As a Neuronal Nuclear Antigen and Neuron Differentiation Marker. Acta Naturae, 7(2), 42–47. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463411/

Harman, D. (1981). The aging process. Proceedings of the National Academy of Sciences of the United States of America, 78(11), 7124–7128. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC349208/

Huang, T.-T., Zou, Y., & Corniola, R. (2012). Oxidative stress and adult neurogenesis – effects of radiation and superoxide dismutase deficiency. Seminars in Cell & Developmental Biology, 23(7), 738–744. https://doi.org/10.1016/j.semcdb.2012.04.003

Jafari, M. J., Khosrowabadi, R., Khodakarim, S., & Mohammadian, F. (2019). The Effect of Noise Exposure on Cognitive Performance and Brain Activity Patterns. Open Access Macedonian Journal of Medical Sciences, 7(17), 2924–2931. https://doi.org/10.3889/oamjms.2019.742

Kumar, A., Pareek, V., Faiq, M. A., Ghosh, S. K., & Kumari, C. (2019). ADULT NEUROGENESIS IN HUMANS: A Review of Basic Concepts, History, Current Research, and Clinical Implications. Innovations in Clinical Neuroscience, 16(5-6), 30–37. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659986/#:~:text=The%20first%20evidence%20of%20adult

Liu, L., Shen, P., He, T., Chang, Y., Shi, L., Tao, S., Li, X., Xun, Q., Guo, X., Yu, Z., & Wang, J. (2016). Noise induced hearing loss impairs spatial learning/memory and hippocampal neurogenesis in mice. Scientific Reports, 6(1). https://doi.org/10.1038/srep20374

Mathews, K. J., Allen, K. M., Boerrigter, D., Ball, H., Shannon Weickert, C., & Double, K. L. (2017). Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers. Aging Cell, 16(5), 1195–1199. https://doi.org/10.1111/acel.12641

Münzel, T., Schmidt, F. P., Steven, S., Herzog, J., Daiber, A., & Sørensen, M. (2018). Environmental Noise and the Cardiovascular System. Journal of the American College of Cardiology, 71(6), 688–697. https://doi.org/10.1016/j.jacc.2017.12.015

Neurogenesis - an overview | ScienceDirect Topics. (n.d.). Www.sciencedirect.com. Retrieved July 16, 2024, from https://www.sciencedirect.com/topics/medicine-and-dentistry/neurogenesis#:~:text=Neurogenesis%20occurring%20in%20the%20dentate

Noise. (2023, October 4). Www.eea.europa.eu. https://www.eea.europa.eu/en/topics/in-depth/noise?activeTab=fa515f0c-9ab0-493c-b4cd-58a32dfaae0a

Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., Squadrito, F., Altavilla, D., & Bitto, A. (2017). Oxidative Stress: Harms and Benefits for Human Health. Oxidative Medicine and Cellular Longevity, 2017(8416763), 1–13. https://doi.org/10.1155/2017/8416763

Poulose, S. M., Miller, M. G., Scott, T., & Shukitt-Hale, B. (2017). Nutritional Factors Affecting Adult Neurogenesis and Cognitive Function. Advances in Nutrition: An International Review Journal, 8(6), 804–811. https://doi.org/10.3945/an.117.016261

Soundproof Cow. (2017, July 21). Top 10 Loudest Cities in the World to Live. Soundproof Cow; Soundproof Cow. https://www.soundproofcow.com/top-10-loudest-cities-world-live/

Spreng, M. (2000). Possible health effects of noise induced cortisol increase. Noise & Health, 2(7), 59–64. https://pubmed.ncbi.nlm.nih.gov/12689472/

Taupin, P. (2007). BrdU immunohistochemistry for studying adult neurogenesis: Paradigms, pitfalls, limitations, and validation. Brain Research Reviews, 53(1), 198–214. https://doi.org/10.1016/j.brainresrev.2006.08.002

United Nations Environment Programme. (2020). Frontiers 2022: Noise, Blazes and Mismatches – Emerging Issues of Environmental Concern. https://www.unep.org/resources/frontiers-2022-noise-blazes-and-mismatches

Urban Noise - an overview | ScienceDirect Topics. (n.d.). Www.sciencedirect.com. https://www.sciencedirect.com/topics/earth-and-planetary-sciences/urban-noise

Zare, S., Baneshi, M. R., Hemmatjo, R., Ahmadi, S., Omidvar, M., & Dehaghi, B. F. (2019). The Effect of Occupational Noise Exposure on Serum Cortisol Concentration of Night-shift Industrial Workers: A Field Study. Safety and Health at Work, 10(1), 109–113. https://doi.org/10.1016/j.shaw.2018.07.002

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Posted

2025-07-13