The Consumption of Artificial Sweeteners Aspartame and Sucralose Possibly Induces Progression of Parkinson’s Disease Through Mutations in SNCA and LRRK2 Genes
DOI:
https://doi.org/10.58445/rars.2689Keywords:
artificial sweeteners, SNCA, LRRK2, genetic mutationAbstract
The present study correlates the onset and progression of Parkinson’s Disease with the use of artificial sweeteners aspartame and sucralose through neuroinflammation, oxidative stress, and the loss of dopaminergic neurons. In this study, the existing literature was extensively reviewed to identify the genetic mutations causing this neurodegenerative disorder. The mutations which were significantly contributing to the induction of Parkinson’s were found in SNCA and LRRK2 genes. To further evaluate the functional aspects of the genetic mutations, the wild type and mutated protein sequences and structures were studied through computational analysis by using tools like multiple sequence alignment and homology modeling. The prolonged consumption of selected artificial sweeteners leads to the generation of free radicals and inflammatory responses in influential neurological regions in Parkinson’s Disease, which leads to the loss of dopaminergic neurons. This study concludes that use of selected artificial sweeteners could interact with the pathways involving mutated genes accelerating the development of Parkinson’s disease.
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