Antihyperglycemic Effect of Combined Pomelo (Citrus maxima) and Banana (Musa × paradisiaca L.) Peel Extract Against Induced Diabetic Sprague Dawley Rats
DOI:
https://doi.org/10.58445/rars.257Keywords:
antihyperglycemic, pomelo, citrus maxima, banana, musa x paradisiaca l., sprague dawley rats, diabetes, hyperglycemiaAbstract
Buildup of blood sugar leads to a condition known as hyperglycemia which is attributed to diabetes mellitus that leads to numerous conditions such as blurry vision, heart problems, and in severe cases, death. In 2022, the mortality rate due to diabetes was 6.6% making it the fourth leading cause of death in the Philippines. Plants bearing fruits have flavonoids, an active compound that exhibits antidiabetic and antihyperglycemic activity. Thus, this study aims to determine the antihyperglycemic effect of combined Pomelo (Citrus maxima) and Banana (Musa x paradisiaca L.) peel extract against induced diabetic Sprague Dawley Rats. In this study, the researchers utilized 3 groups with 2 rats each, an experimental group treated with 50% PPE: 50% BPE, a positive control group treated with the commercially available antihyperglycemic drug Metformin, and a negative control group. After the treatment period, the results have shown that both fruit extracts and the commercially available drug was effective in lowering the blood glucose levels of the rats with an average percent decrease of 64.94% and 83.49% respectively however the untreated rats also present an average percent decrease of 64.81%. Afterwards, the data was statistically analyzed using ANOVA with an alpha value of 0.01. However, the result shows a p-value 0.489306 which is higher than the desired alpha value. In general, combined Pomelo (Citrus maxima) and Banana (Musa x paradisiaca L.) peel extract was effective in lowering the blood glucose level of the rats but not as effective as commercially available antihyperglycemic drug.
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