The Effects of COX-1 Enzyme Inhibitions by NSAIDs
DOI:
https://doi.org/10.58445/rars.2398Keywords:
COX-1, NSAIDsAbstract
Cyclooxygenase-1 (COX-1) is a crucial enzyme responsible for the biosynthesis of prostaglandins, which regulate various physiological functions, including gastric mucosal protection. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit COX-1, preventing the production of prostaglandins which maintain gastric integrity by promoting mucous secretion and vasodilation. This review explores the molecular mechanism of COX-1 catalysis, detailing the oxidation of arachidonic acid into prostaglandin intermediates and the impact of NSAID inhibition on gastrointestinal health.
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Image References
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