Homeostatic Response Mechanisms in Cancer Chemotherapy
DOI:
https://doi.org/10.58445/rars.2356Keywords:
biology, cancer, homeostasis, dual role of cancer cellsAbstract
This review explores the mechanisms by which cancer cells use adaptive, homeostatic responses to resist chemotherapy. This paper reviews the basic biology of cancer and the ability of cancer cells to resist and tolerate cancer treatments. Then, the discussion will examine three homeostatic mechanisms of chemotherapy resistance: antioxidant metabolism, autophagy, and the endoplasmic reticulum (ER) stress response. Additionally, the paper addresses how these mechanisms mediating cancer resistance contribute to homeostasis in healthy cells and how essential cell organelles and proteins promote tumour survival for cancer cells. Despite the advancement in cancer treatment, scientists still struggle to understand the dual role of these three mechanisms.
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