Brain-Body Connection of Chronic Drug Abuse
DOI:
https://doi.org/10.58445/rars.1977Keywords:
Opioids, Addiction, Opioid Use Disorder, Cannabis, NeuroscienceAbstract
Opioids have a longstanding history in medicine and are also the subject of the ongoing substance abuse epidemic in the United States. In addition to strong analgesic (pain-relief) properties, synthetic opioids also have high addiction potential and their long-term abuse can result in fatal outcomes. The mechanisms and outcomes associated with the long-term abuse of synthetic opioids involve both the body and mind. In this review article, key organ systems and brain areas affected by long-term opioid use are summarized. Additionally, possible mechanisms that underlie the effects mediated by long-term opioid abuse are included. Lastly, this review article provides an overview of interventional approaches under current investigation for the treatment and management of opioid use disorders. It is important research on opioids is continued to better help those suffering from opioid use disorders.
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