The Effects of the ABCC11 Gene in Breast Cancer
Universal Difference, Carcinogenesis, and Therapeutic Possibilities
DOI:
https://doi.org/10.58445/rars.1958Keywords:
Breast cancer, ABCC11, gene, genetic mutation, Cancer TreatmentAbstract
Cancer has been a detrimental cause of death and a persistent global health issue for millennia. Breast cancer, in specific, has been one of the most prevalent types of cancer, especially in women. This paper presents the roles of a genetic mutation present within ABCC11, specifically the SNP rs17822931 538G>A, in breast cancer carcinogenesis, pre diagnosis, and possible treatment outcomes. While the ABCC11 protein functions as a transporter for specific molecules within cells, the genetic mutations, particularly the WT (wild-type) allele (538Gly), are linked to phenotypic expressions of wet earwax, axillary osmidrosis, and an increased risk of breast cancer incidence. While the WT (538Gly) allele is more frequent in African and Caucasian populations, the variant allele (538Arg) is more prevalent in the Eastern Asian population. With further research, the functions of the ABCC11 protein and the phenotypic expressions of ABCC11 may be utilized as a method for early genetic screening for breast cancer development and offers future therapeutic possibilities, improving breast cancer outcomes.
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