Preprint / Version 1

Investigating Methods to Promote Neuroplasticity and Brain Regeneration following a Stroke

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  • SriKeerthana Kotturu Kotturu Polygence

DOI:

https://doi.org/10.58445/rars.1926

Keywords:

stroke, neuroplasticity, ischemia, physical therapy, cognitive therapy, pharmacological therapy, synaptic plasticity

Abstract

 

Stroke is one of the most common causes of physical and mental disability and is a ubiquitous neurological impairment throughout the world. In the United States, an individual is impacted by a stroke every 40 seconds. While there currently are FDA approved therapies, such as clot-dissolving anticoagulants and procedural thrombectomies, or the process to medically remove a clot, they only aim for restoring the proper blood flow to the affected area rather than providing an overall solution to prevent further damage.This highlights the necessity for therapies that not only restore blood flow, but also promote neuroplasticity, or the brain’s ability to reorganize and recover itself by repairing broken connections. The medical field could improve stroke treatment by focusing on the promotion of neuroplasticity. This paper explores a multitude of therapies designed to promote neuroplasticity after a stroke from different categories: cognitive, physical, and pharmacological. 

 

References

Acharya, A., & Wroten, M. (2023). Broca Aphasia—StatPearls—NCBI Bookshelf.

Barthels, D., & Das, H. (2020). Current advances in ischemic stroke research and therapies. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1866(4), 165260. https://doi.org/10.1016/j.bbadis.2018.09.012

Dobkin, B. H., & Dorsch, A. (2013). New Evidence for Therapies in Stroke Rehabilitation. Current Atherosclerosis Reports, 15(6), 331. https://doi.org/10.1007/s11883-013-0331-y

Hacke, W., Kaste, M., Bluhmki, E., Brozman, M., Dávalos, A., Guidetti, D., Larrue, V., Lees, K. R., Medeghri, Z., Machnig, T., Schneider, D., von Kummer, R., Wahlgren, N., & Toni, D. (2008). Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke. New England Journal of Medicine, 359(13), 1317–1329. https://doi.org/10.1056/NEJMoa0804656

Hill, G., Johnson, F., Uy, J., Serrada, I., Benyamin, B., Van Den Berg, M., & Hordacre, B. (2023). Moderate intensity aerobic exercise may enhance neuroplasticity of the contralesional hemisphere after stroke: A randomised controlled study. Scientific Reports, 13(1), 14440. https://doi.org/10.1038/s41598-023-40902-2

Hui, C., Tadi, P., Suheb, M. Z. K., & Patti, L. (2024). Ischemic Stroke. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK499997/

Lv, Q., Zhang, J., Pan, Y., Liu, X., Miao, L., Peng, J., Song, L., Zou, Y., & Chen, X. (2022). Somatosensory Deficits After Stroke: Insights From MRI Studies. Frontiers in Neurology, 13, 891283. https://doi.org/10.3389/fneur.2022.891283

Marín-Medina, D. S., Arenas-Vargas, P. A., Arias-Botero, J. C., Gómez-Vásquez, M., Jaramillo-López, M. F., & Gaspar-Toro, J. M. (2024). New approaches to recovery after stroke. Neurological Sciences, 45(1), 55–63. https://doi.org/10.1007/s10072-023-07012-3

Martin, S. S., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Barone Gibbs, B., Beaton, A. Z., Boehme, A. K., Commodore-Mensah, Y., Currie, M. E., Elkind, M. S. V., Evenson, K. R., Generoso, G., Heard, D. G., Hiremath, S., Johansen, M. C., Kalani, R., … on behalf of the American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. (2024). 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association. Circulation, 149(8). https://doi.org/10.1161/CIR.0000000000001209

Price, A. J., Wright, F. L., Green, J., Balkwill, A., Kan, S. W., Yang, T. O., Floud, S., Kroll, M. E., Simpson, R., Sudlow, C. L. M., Beral, V., & Reeves, G. K. (2018). Differences in risk factors for 3 types of stroke: UK prospective study and meta-analyses. Neurology, 90(4). https://doi.org/10.1212/WNL.0000000000004856

Tenny, S., & Thorell, W. (2024). Intracranial Hemorrhage—StatPearls—NCBI Bookshelf.

Virani, S. S., Alonso, A., Aparicio, H. J., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Cheng, S., Delling, F. N., Elkind, M. S. V., Evenson, K. R., Ferguson, J. F., Gupta, D. K., Khan, S. S., Kissela, B. M., Knutson, K. L., Lee, C. D., Lewis, T. T., … On behalf of the American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. (2021). Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association. Circulation, 143(8). https://doi.org/10.1161/CIR.0000000000000950

Yadav, R. S., Chaudhary, D., Avula, V., Shahjouei, S., Azarpazhooh, M. R., Abedi, V., Li, J., & Zand, R. (2022). Social Determinants of Stroke Hospitalization and Mortality in United States’ Counties. Journal of Clinical Medicine, 11(14), 4101. https://doi.org/10.3390/jcm11144101

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Posted

2024-11-05