Review of Chronic Kidney Disease and Comparison Between Humans, Dogs, and Cats
DOI:
https://doi.org/10.58445/rars.186Keywords:
cdk, Chronic Kidney Disease, Dogs, Canines, Cats, Felines, Humans, Renal, Kidney, Kidney Transplantation, Dialysis, Hypertension, DiabetesAbstract
The kidney is the body’s filter and when it is damaged, the body no longer functions the way it should. When enough damage has occurred to the kidney, the kidneys will slowly start to fail resulting in chronic kidney disease (CKD). There is no cure for CKD and it gets progressively worse over time. CKD affects a wide variety of animal species, including humans, dogs, and cats. We will be comparing CKD prevalence, symptoms, risk factors, and treatment modalities. There are many similarities in disease diagnosis, monitoring, and treatment between the species. There are also key differences in each species' physiology that results in different diagnostic and monitoring parameters as well as differences in the treatment options available. We compare CKD treatment options that include kidney transplantation, dialysis, hypertension, and nutrition. As part of the One Health movement, understanding these similarities and differences will help us better understand the disease process and hopefully improve treatment outcomes across species.
References
A “New Normal”: Life on Dialysis-The First 90 Days. (n.d.). National Kidney Foundation. https://www.kidney.org/sites/default/files/docs/11-10-0307_dialysistransitionbk2_oct07_lr_bm.pdf
Acierno, M. J., Brown, S., Coleman, A. E., Jepson, R. E., Papich, M., Stepien, R. L., & Syme, H. M. (2018). ACVIM consensus statement: Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. Journal of Veterinary Internal Medicine, 32(6), 1803–1822. https://doi.org/10.1111/jvim.15331
Acierno, M. J., & Labato, M. A. (2005). Hypertension in renal disease: Diagnosis and treatment. Clinical Techniques in Small Animal Practice, 20(1), 23–30. https://doi.org/10.1053/j.ctsap.2004.12.004
Aronson, L. R. (2016). Update on the Current Status of Kidney Transplantation for Chronic Kidney Disease in Animals. Veterinary Clinics of North America: Small Animal Practice, 46(6), 1193–1218. https://doi.org/10.1016/j.cvsm.2016.06.013
Bartges, J. W. (2012). Chronic Kidney Disease in Dogs and Cats. Veterinary Clinics of North America: Small Animal Practice, 42(4), 669–692. https://doi.org/10.1016/j.cvsm.2012.04.008
Bartlett, P. C., Van Buren, J. W., Bartlett, A. D., & Zhou, C. (2010). Case-Control Study of Risk Factors Associated with Feline and Canine Chronic Kidney Disease. Veterinary Medicine International, 2010, 1–9. https://doi.org/10.4061/2010/957570
Bernsteen, L., Gregory, C. R., Kyles, A. E., Wooldridge, J. D., & Valverde, C. R. (2000). Renal transplantation in cats. Clinical Techniques in Small Animal Practice, 15(1), 40–45. https://doi.org/10.1053/svms.2000.7303
Bijnen, A. B., & Obertop, H. (n.d.). Kidney Transplantation. https://www.osti.gov/servlets/purl/6637778#page=213
Brock, D. W. (1992). Voluntary Active Euthanasia. The Hastings Center Report, 22(2), 10. https://doi.org/10.2307/3562560
Buffington, C. A. T. (2008). Dry foods and risk of disease in cats. The Canadian Veterinary Journal = La Revue Veterinaire Canadienne, 49(6), 561–563.
Chazot, C. (2009). Why Are Chronic Kidney Disease Patients Anorexic and What Can Be Done About It? Seminars in Nephrology, 29(1), 15–23. https://doi.org/10.1016/j.semnephrol.2008.10.003
Chronic Kidney Disease in the United States, 2021. (2021). Center for Disease Control and Prevention (CDC). https://www.cdc.gov/kidneydisease/publications-resources/ckd-national-facts.html
Cohuet, G., & Struijker-Boudier, H. (2006). Mechanisms of target organ damage caused by hypertension: Therapeutic potential. Pharmacology & Therapeutics, 111(1), 81–98. https://doi.org/10.1016/j.pharmthera.2005.09.002
Cortinovis, C., & Caloni, F. (2016). Household Food Items Toxic to Dogs and Cats. Frontiers in Veterinary Science, 3. https://doi.org/10.3389/fvets.2016.00026
Cowgill, L. D., & Langston, C. E. (1996). Role of Hemodialysis in the Management of Dogs and Cats with Renal Failure. Veterinary Clinics of North America: Small Animal Practice, 26(6), 1347–1378. https://doi.org/10.1016/S0195-5616(96)50132-4
Dialysis: Types, How It Works, Procedure & Side Effects. (n.d.). Retrieved May 26, 2022, from https://my.clevelandclinic.org/health/treatments/14618-dialysis
Elliott, D. A. (2000). Hemodialysis. Clinical Techniques in Small Animal Practice, 15(3), 136–148. https://doi.org/10.1053/svms.2000.18297
Elliott, J., Barber, P. J., Syme, H. M., Rawlings, J. M., & Markwell, P. J. (2001). Feline hypertension: Clinical findings and response to antihypertensive treatment in 30 cases. Journal of Small Animal Practice, 42(3), 122–129. https://doi.org/10.1111/j.1748-5827.2001.tb02008.x
End-stage renal disease. (2021). Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/end-stage-renal-disease/symptoms-causes/syc-20354532
Feline Kidney Transplantation—General Information. (n.d.). Retrieved May 26, 2022, from https://www.vetmed.wisc.edu/dss/mcanulty/felinekidneytransplant/generalinfo.html
Finch, N. C., Syme, H. M., & Elliott, J. (2016). Risk Factors for Development of Chronic Kidney Disease in Cats. Journal of Veterinary Internal Medicine, 30(2), 602–610. https://doi.org/10.1111/jvim.13917
Find and Compare Transplant Programs. (n.d.). Retrieved May 27, 2022, from https://www.srtr.org/
Fischer, J. R., Pantaleo, V., Francey, T., & Cowgill, L. D. (2004). Veterinary hemodialysis: Advances in management and technology. Veterinary Clinics of North America: Small Animal Practice, 34(4), 935–967. https://doi.org/10.1016/j.cvsm.2004.03.007
Ghys, L., Paepe, D., Smets, P., Lefebvre, H., Delanghe, J., & Daminet, S. (2014). Cystatin C: A New Renal Marker and Its Potential Use in Small Animal Medicine. Journal of Veterinary Internal Medicine, 28(4), 1152–1164. https://doi.org/10.1111/jvim.12366
Hall, J. E., Henegar, J. R., Dwyer, T. M., Liu, J., da Silva, A. A., Kuo, J. J., & Tallam, L. (2004). Is obesity a major cause of chronic kidney disease? Advances in Renal Replacement Therapy, 11(1), 41–54. https://doi.org/10.1053/j.arrt.2003.10.007
Hamrahian, S. M., & Falkner, B. (2016). Hypertension in Chronic Kidney Disease. In Md. S. Islam (Ed.), Hypertension: From basic research to clinical practice (Vol. 956, pp. 307–325). Springer International Publishing. https://doi.org/10.1007/5584_2016_84
Harley, L., & Langston, C. (2012). Proteinuria in dogs and cats. The Canadian Veterinary Journal = La Revue Veterinaire Canadienne, 53(6), 631–638.
Hemodialysis vs. Peritoneal Dialysis in Veterinary Practice of Thailand—WSAVA 2015 Congress—VIN. (n.d.). Retrieved May 26, 2022, from https://www.vin.com/apputil/content/defaultadv1.aspx?pId=14365&catId=73690&id=7259181
High Blood Pressure and Chronic Kidney Disease | National Kidney Foundation. (n.d.). Retrieved May 26, 2022, from https://www.kidney.org/news/newsroom/factsheets/High-Blood-Pressure-and-CKD
Hopper, K., Mehl, M. L., Kass, P. H., Kyles, A., & Gregory, C. R. (2012). Outcome after Renal Transplantation in 26 Dogs: Renal Transplantation in Dogs. Veterinary Surgery, n/a-n/a. https://doi.org/10.1111/j.1532-950X.2011.00924.x
Hori, Y., Heishima, Y., Yamashita, Y., Isayama, N., Kanno, N., Nakamura, K., Iguchi, M., Ibaragi, T., Onodera, H., Aramaki, Y., Hirakawa, A., Yamano, S., Katagi, M., Kitade, A., & Sawada, T. (2018). Relationship between indirect blood pressure and various stages of chronic kidney disease in cats. Journal of Veterinary Medical Science, 80(3), 447–452. https://doi.org/10.1292/jvms.17-0620
IRIS Staging of CKD. (2019). International Renal Interest Society. http://www.iris-kidney.com/pdf/IRIS_Staging_of_CKD_modified_2019.pdf
Kannel, W. B., Gordon, T., & Schwartz, M. J. (1971). Systolic versus diastolic blood pressure and risk of coronary heart disease. The Amer
ican Journal of Cardiology, 27(4), 335–346. https://doi.org/10.1016/0002-9149(71)90428-0
Karadeniz Teknik Universitesi Saglik Bilimleri Fakultesi, Hemsirelik Bolumu, Trabzon, Turkiye, Hintistan, S., Deniz, A., & Ege Universitesi Saglik Bilimleri Enstitusu, Ic Hastaliklari Hemsireligi Anabilim Dali, Izmir, Turkiye. (2018).
Evaluation of Symptoms in Patients Undergoing Hemodialysis. Bezmialem Science, 6(2), 112–118. https://doi.org/10.14235/bs.2018.1530
Keep Lilies Away From Your Cats | FDA. (n.d.). Retrieved May 26, 2022, from https://www.fda.gov/consumers/consumer-updates/keep-lilies-away-your-cats
Khalil, A., Mujtaba, M. A., Taber, T. E., Yaqub, M. S., Goggins, W., Powelson, J., Sundaram, C., & Sharfuddin, A. A. (2016). Trends and outcomes in right vs. left living donor nephrectomy: An analysis of the OPTN/UNOS database of donor and recipient outcomes - should we be doing more right-sided nephrectomies? Clinical Transplantation, 30(2), 145–153. https://doi.org/10.1111/ctr.12668
Kidney Transplant | Johns Hopkins Medicine. (n.d.). Retrieved May 26, 2022, from https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/kidney-transplant
Kidney transplant—Mayo Clinic. (n.d.). Retrieved May 26, 2022, from https://www.mayoclinic.org/tests-procedures/kidney-transplant/about/pac-20384777
Kistler, B. M., Moore, L. W., Benner, D., Biruete, A., Boaz, M., Brunori, G., Chen, J., Drechsler, C., Guebre-Egziabher, F., Hensley, M. K., Iseki, K., Kovesdy, C. P., Kuhlmann, M. K., Saxena, A., Wee, P. ter, Brown-Tortorici, A., Garibotto, G., Price, S. R., Yee-Moon Wang, A., & Kalantar-Zadeh, K. (2021). The International Society of Renal Nutrition and Metabolism Commentary on the National Kidney Foundation and Academy of Nutrition and Dietetics KDOQI Clinical Practice Guideline for Nutrition in Chronic Kidney Disease. Journal of Renal Nutrition, 31(2), 116-120.e1. https://doi.org/10.1053/j.jrn.2020.05.002
Kobayashi, D. L., Peterson, M. E., Graves, T. K., Nichols, C. E., & Lesser, M. (1990). Hypertension in Cats With Chronic Renal Failure or Hyperthyroidism. Journal of Veterinary Internal Medicine, 4(2), 58–62. https://doi.org/10.1111/j.1939-1676.1990.tb03104.x
Ku, E., Lee, B. J., Wei, J., & Weir, M. R. (2019). Hypertension in CKD: Core Curriculum 2019. American Journal of Kidney Diseases, 74(1), 120–131. https://doi.org/10.1053/j.ajkd.2018.12.044
Langston, C. (2002). Hemodialysis in Dogs and Cats. Animal Medical Center. http://assets.prod.vetlearn.com.s3.amazonaws.com/mmah/8e/efd8039d3f4bc89419bad076753184/filePV_24_07_540.pdf
Langston, C. (2017). Managing Fluid and Electrolyte Disorders in Kidney Disease. Veterinary Clinics of North America: Small Animal Practice, 47(2), 471–490. https://doi.org/10.1016/j.cvsm.2016.09.011
Lee, K.-Y. (2017). A unified pathogenesis for kidney diseases, including genetic diseases and cancers, by the protein-homeostasis-system hypothesis. Kidney Research and Clinical Practice, 36(2), 132–144. https://doi.org/10.23876/j.krcp.2017.36.2.132
Levy, D., Larson, M. G., Vasan, R. S., Kannel, W. B., & Ho, K. K. (1996). The progression from hypertension to congestive heart failure. JAMA, 275(20), 1557–1562.
Living-donor kidney transplant—Type—Mayo Clinic. (n.d.). Retrieved May 26, 2022, from https://www.mayoclinic.org/tests-procedures/living-donor-kidney-transplant/pyc-20384838
Macdougall, D. F., Cook, T., Steward, A. P., & Cattell, V. (1986). Canine chronic renal disease: Prevalence and types of glomerulonephritis in the dog. Kidney International, 29(6), 1144–1151. https://doi.org/10.1038/ki.1986.120
Malkina, A. (2021). Chronic Kidney Disease. Merck Manual. https://www.merckmanuals.com/professional/genitourinary-disorders/chronic-kidney-disease/chronic-kidney-disease?query=ckd#v1054161
Marino, C. L., Lascelles, B. D. X., Vaden, S. L., Gruen, M. E., & Marks, S. L. (2014). Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies. Journal of Feline Medicine and Surgery, 16(6), 465–472. https://doi.org/10.1177/1098612X13511446
Mathews, K. G., & Gregory, C. R. (1997). Renal transplants in cats: 66 cases (1987-1996). Journal of the American Veterinary Medical Association, 211(11), 1432–1436.
McGrotty, Y. (2008). Diagnosis and management of chronic kidney disease in dogs and cats. In Practice, 30(9), 502–507. https://doi.org/10.1136/inpract.30.9.502
Medications After Kidney Transplant | Transplant Center | UC Davis Health. (n.d.). Retrieved May 26, 2022, from https://health.ucdavis.edu/transplant/about/medications-after-kidney-transplant.html
Muir, W. W. (2003). Clinical veterinary toxicology. Elsevier Mosby.
Nielsen, J. Ø., Shrestha, A. D., Neupane, D., & Kallestrup, P. (2017). Non-adherence to anti-hypertensive medication in low- and middle-income countries: A systematic review and meta-analysis of 92443 subjects. Journal of Human Hypertension, 31(1), 14–21. https://doi.org/10.1038/jhh.2016.31
Notice. (2013). Kidney International Supplements, 3(1), 1. https://doi.org/10.1038/kisup.2012.73
Novellas, R., Ruiz de Gopegui, R., & Espada, Y. (2010). Assessment of renal vascular resistance and blood pressure in dogs and cats with renal disease. Veterinary Record, 166(20), 618–623. https://doi.org/10.1136/vr.b4820
O’Connell, P. J., Brown, M., Chan, T. M., Claure-Del Granado, R., Davies, S. J., Eiam-Ong, S., Hassan, M. H., Kalantar-Zadeh, K., Levin, A., Martin, D. E., Muller, E., Ossareh, S., Tchokhonelidze, I., Trask, M., Twahir, A., Were, A. J. O., Yang, C.-W., Zemchenkov, A., & Harden, P. N. (2020). The role of kidney transplantation as a component of integrated care for chronic kidney disease. Kidney International Supplements, 10(1), e78–e85. https://doi.org/10.1016/j.kisu.2019.11.006
Ong, K. L., Cheung, B. M. Y., Man, Y. B., Lau, C. P., & Lam, K. S. L. (2007). Prevalence, Awareness, Treatment, and Control of Hypertension Among United States Adults 1999–2004. Hypertension, 49(1), 69–75. https://doi.org/10.1161/01.HYP.0000252676.46043.18
Oxalis (Clover, Good Luck Plant, Lucky Clover, Oxalis, Shamrock, Shamrock Plant, Sorrel, Wood-sorrel) | North Carolina Extension Gardener Plant Toolbox. (n.d.). Retrieved May 26, 2022, from https://plants.ces.ncsu.edu/plants/oxalis/
Parker, V. J. (2021). Nutritional Management for Dogs and Cats with Chronic Kidney Disease. Veterinary Clinics of North America: Small Animal Practice, 51(3), 685–710. https://doi.org/10.1016/j.cvsm.2021.01.007
Penn Vet | Renal Transplantation. (n.d.). Retrieved May 26, 2022, from https://www.vet.upenn.edu/veterinary-hospitals/ryan-veterinary-hospital/services/advanced-urinary-care/urinary-care-services/renal-transplantation
Perini-Perera, S., Del-Ángel-Caraza, J., Pérez-Sánchez, A. P., Quijano-Hernández, I. A., & Recillas-Morales, S. (2021). Evaluation of Chronic Kidney Disease Progression in Dogs With Therapeutic Management of Risk Factors. Frontiers in Veterinary Science, 8, 621084. https://doi.org/10.3389/fvets.2021.621084
Port, F. K. (1993). Comparison of Survival Probabilities for Dialysis Patients vs Cadaveric Renal Transplant Recipients. JAMA: The Journal of the American Medical Association, 270(11), 1339. https://doi.org/10.1001/jama.1993.03510110079036
Rao, M. V., Qiu, Y., Wang, C., & Bakris, G. (2008). Hypertension and CKD: Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES), 1999-2004. American Journal of Kidney Diseases, 51(4), S30–S37. https://doi.org/10.1053/j.ajkd.2007.12.012
Romagnani, P., Remuzzi, G., Glassock, R., Levin, A., Jager, K. J., Tonelli, M., Massy, Z., Wanner, C., & Anders, H.-J. (2017). Chronic kidney disease. Nature Reviews Disease Primers, 3(1), 17088. https://doi.org/10.1038/nrdp.2017.88
Schmiedt, C. W., Holzman, G., Schwarz, T., & McANULTY, J. F. (2008). Survival, Complications, and Analysis of Risk Factors after Renal Transplantation in Cats. Veterinary Surgery, 37(7), 683–695. https://doi.org/10.1111/j.1532-950X.2008.00435.x
Schnuelle, P., Lorenz, D., Trede, M., & Van Der Woude, F. J. (1998). Impact of renal cadaveric transplantation on survival in end-stage renal failure: Evidence for reduced mortality risk compared with hemodialysis during long-term follow-up. Journal of the American Society of Nephrology, 9(11), 2135–2141. https://doi.org/10.1681/ASN.V9112135
Steuer, R. R., Leypoldt, J. K., Cheung, A. K., Senekjian, H. O., & Conis, J. M. (1996). Reducing symptoms during hemodialysis by continuously monitoring the hematocrit. American Journal of Kidney Diseases, 27(4), 525–532. https://doi.org/10.1016/S0272-6386(96)90163-8
Tandukar, S., & Palevsky, P. M. (2019). Continuous Renal Replacement Therapy. Chest, 155(3), 626–638. https://doi.org/10.1016/j.chest.2018.09.004
Tedla, F. M., Brar, A., Browne, R., & Brown, C. (2011). Hypertension in Chronic Kidney Disease: Navigating the Evidence. International Journal of Hypertension, 2011, 1–9. https://doi.org/10.4061/2011/132405
Tenhündfeld, J., Wefstaedt, P., & Nolte, I. J. A. (2009). A randomized controlled clinical trial of the use of benazepril and heparin for the treatment of chronic kidney disease in dogs. Journal of the American Veterinary Medical Association, 234(8), 1031–1037. https://doi.org/10.2460/javma.234.8.1031
The Kidney Transplant Waitlist – What You Need to Know | National Kidney Foundation. (n.d.). Retrieved May 26, 2022, from https://www.kidney.org/atoz/content/transplant-waitlist
Tonelli, M., Wiebe, N., Knoll, G., Bello, A., Browne, S., Jadhav, D., Klarenbach, S., & Gill, J. (2011). Systematic Review: Kidney Transplantation Compared With Dialysis in Clinically Relevant Outcomes: Systematic Review of Kidney Transplantation. American Journal of Transplantation, 11(10), 2093–2109. https://doi.org/10.1111/j.1600-6143.2011.03686.x
van der Veen, P. H., Geerlings, M. I., Visseren, F. L. J., Nathoe, H. M., Mali, W. P. T. M., van der Graaf, Y., & Muller, M. (2015). Hypertensive Target Organ Damage and Longitudinal Changes in Brain Structure and Function: The Second Manifestations of Arterial Disease–Magnetic Resonance Study. Hypertension, 66(6), 1152–1158. https://doi.org/10.1161/HYPERTENSIONAHA.115.06268
Vieth, J. T., & Lane, D. R. (2014). Anemia. Emergency Medicine Clinics of North America, 32(3), 613–628. https://doi.org/10.1016/j.emc.2014.04.007
What is peritoneal dialysis? | National Kidney Foundation. (n.d.). Retrieved May 26, 2022, from https://www.kidney.org/atoz/content/peritoneal
Yang, C.-W. (2007). Leptospirosis renal disease: Understanding the initiation by Toll-like receptors. Kidney International, 72(8), 918–925. https://doi.org/10.1038/sj.ki.5002393
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