Rosin-based ointment for treating Psoriasis

Abstract

Psoriasis is a chronic, immune-mediated skin disorder characterized by the overproduction of keratinocytes and inflammation, resulting in scaly, erythematous plaques that significantly impact quality of life. Conventional treatments, such as topical agents, phototherapy, and systemic therapies, often have side effects or limited long-term efficacy, highlighting the need for safer and more effective alternatives. This study investigates the formulation of a novel topical ointment using gum rosin, salicylic acid, glycerol, olive oil, and vitamin E to address the key pathological features of psoriasis. Gum rosin’s anti-inflammatory properties, combined with the keratolytic effects of salicylic acid and the emollient benefits of glycerol and olive oil, offer a multifaceted approach to psoriasis treatment. Three volunteers with mild to moderate psoriasis applied the ointment twice daily over four weeks, with all showing marked clinical improvement, particularly in reducing erythema, scaling, and improving skin texture within two weeks. One participant, whose symptoms had worsened from cortisone-based treatment, experienced rapid symptom relief with the ointment. No adverse effects were reported, suggesting the ointment's safety and efficacy. While the results are promising, the small sample size and short duration underscore the need for larger-scale clinical trials to confirm its potential as a cost-effective, safe alternative for long-term management of psoriasis.