Preprint / Version 1

The Determinants of the Long-term Impacts of Tuberculosis in Poverty-stricken Areas

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  • Yuna Suh Polygence

DOI:

https://doi.org/10.58445/rars.1757

Keywords:

Tuberculosis, poverty, biology

Abstract

Tuberculosis (TB) is an infectious disease that affects millions of people worldwide. Despite the developments of treatments and various methods to diagnose it, it remains a large threat, especially in underdeveloped, crisis-affected, or low-income countries. As numbers of drug-resistant strains increase, these countries are at greater risk. Various factors that are present in such countries affect the increase in the prevalence of TB, including lack of healthcare and education, high HIV prevalence, pollution, and migration. These factors magnify the long-term effects in crisis-affected and low-income countries, which include both physical, emotional, and financial losses. TB leads to decreased lung function even after successful treatment, requiring the individual to pay for continued medical care. This poses a great financial concern for those in low-income countries where patients may face unemployment and loss of savings. Therefore, more research is required to improve the accessibility of TB treatments and diagnostic exams.

References

Akalu, T. Y., Clements, A. C. A., Baraki, A. G., & Alene, K. A. (2023). Protocol for a systematic review of long-term physical sequelae and financial burden of multidrug-resistant and extensively drug-resistant tuberculosis. PLOS ONE, 18(5), e0285404. https://doi.org/10.1371/journal.pone.0285404

Carrasco-Escobar, G., Schwalb, A., Tello-Lizarraga, K., Vega-Guerovich, P., & Ugarte-Gil, C. (2020). Spatio-temporal co-occurrence of hotspots of tuberculosis, poverty and air pollution in Lima, Peru. Infectious Diseases of Poverty, 9(1), 32. https://doi.org/10.1186/s40249-020-00647-w

Cortez, A. O., de Melo, A. C., Neves, L. de O., Resende, K. A., & Camargos, P. (2021). Tuberculosis in Brazil: One country, multiple realities. Jornal Brasileiro de Pneumologia, 47(2), e20200119. https://doi.org/10.36416/1806-3756/e20200119

Dale, K. D., Trauer, J. M., Dodd, P. J., Houben, R. M. G. J., & Denholm, J. T. (2020). Estimating Long-term Tuberculosis Reactivation Rates in Australian Migrants. Clinical Infectious Diseases, 70(10), 2111–2118. https://doi.org/10.1093/cid/ciz569

Fekadu, L., Hanson, C., Osberg, M., Makayova, J., Mingkwan, P., & Chin, D. (2017). Increasing Access to Tuberculosis Services in Ethiopia: Findings From a Patient-Pathway Analysis. The Journal of Infectious Diseases, 216(Suppl 7), S696–S701. https://doi.org/10.1093/infdis/jix378

Harling, G., Lima Neto, A. S., Sousa, G. S., Machado, M. M. T., & Castro, M. C. (2017). Determinants of tuberculosis transmission and treatment abandonment in Fortaleza, Brazil. BMC Public Health, 17, 508. https://doi.org/10.1186/s12889-017-4435-0

Ismail, N., Nathanson, C.-M., Zignol, M., & Kasaeva, T. (2023). Achieving universal access to rapid tuberculosis diagnostics. BMJ Global Health, 8(5), e012666. https://doi.org/10.1136/bmjgh-2023-012666

Marx, F. M., Cohen, T., Menzies, N. A., Salomon, J. A., Theron, G., & Yaesoubi, R. (2020). Cost-effectiveness of post-treatment follow-up examinations and secondary prevention of tuberculosis in a high-incidence setting: A model-based analysis. The Lancet. Global Health, 8(9), e1223–e1233. https://doi.org/10.1016/S2214-109X(20)30227-8

Meghji, J., Gregorius, S., Madan, J., Chitimbe, F., Thomson, R., Rylance, J., Banda, N. P., Gordon, S. B., Corbett, E. L., Mortimer, K., & Squire, S. B. (2021). The long term effect of pulmonary tuberculosis on income and employment in a low income, urban setting. Thorax, 76(4), 387–395. https://doi.org/10.1136/thoraxjnl-2020-215338

Meghji, J., Simpson, H., Squire, S. B., & Mortimer, K. (2016). A Systematic Review of the Prevalence and Pattern of Imaging Defined Post-TB Lung Disease. PLoS ONE, 11(8), e0161176. https://doi.org/10.1371/journal.pone.0161176

Murray, M., & Nardell, E. (2002). Molecular epidemiology of tuberculosis: Achievements and challenges to current knowledge. Bulletin of the World Health Organization, 80(6), 477–482.

Romanowski, K., Baumann, B., Basham, C. A., Khan, F. A., Fox, G. J., & Johnston, J. C. (2019). Long-term all-cause mortality in people treated for tuberculosis: A systematic review and meta-analysis. The Lancet Infectious Diseases, 19(10), 1129–1137. https://doi.org/10.1016/S1473-3099(19)30309-3

Tadyanemhandu. (n.d.). Treatment success, but living with the consequences of post-tuber...: Ingenta Connect. Retrieved January 2, 2024, from https://www.ingentaconnect.com/content/iuatld/ijtld/2020/00000024/00000007/art00001#

Tuberculosis after Initiation of Antiretroviral Therapy in Low-Income and High-Income Countries. (2007). Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 45(11), 1518–1521. https://doi.org/10.1086/522986

Zenner, D. (2017). Crisis-Affected Populations and Tuberculosis. Microbiology Spectrum, 5(1), 10.1128/microbiolspec.tnmi7-0031–2016. https://doi.org/10.1128/microbiolspec.tnmi7-0031-2016

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2024-10-15

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