Exploring the Effects of the Gut Microbiome on Alzheimer’s Disease
DOI:
https://doi.org/10.58445/rars.1712Keywords:
Alzheimer’s disease, Gut microbiota, Neuroinflammation, Nutrition, ProbioticsAbstract
Alzheimer’s disease is a progressive neurodegenerative disorder that is exacerbated by neuroinflammation linked to gut microbiome imbalances. Dysbiosis has been shown to increase neuroinflammation and facilitate the infiltration of lipopolysaccharides (LPS) into the brain, worsening Alzheimer's pathology. Key approaches discussed include ketogenic and Mediterranean diets, as well as multi-strain probiotics like Bifidobacterium breve A1, which may reduce oxidative stress and inflammation while enhancing short-chain fatty acid (SCFA) levels. Given the growing prevalence of Alzheimer's disease and the limited value of current treatments, understanding the role of the gut-brain axis offers a promising avenue for novel therapeutic interventions. By targeting gut microbiome imbalances, it may be possible to mitigate neuroinflammation and slow disease progression, providing new hope for patients and their families.
Keywords: Alzheimer’s disease, Gut microbiota, Neuroinflammation, Nutrition, Probiotics
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