Epigenetics and Neurological Disorders
DOI:
https://doi.org/10.58445/rars.1655Keywords:
Epigenetics, Neuroscience, Genes, Gene Expression, Therapeutics, Huntington's Disease, Alzheimer's DiseaseAbstract
Epigenetics, with its diverse mechanisms such as DNA methylation, histone acetylation, and ncRNAs, holds significant therapeutic potential for a wide range of disorders and diseases. Its intrinsic adaptability prevents DNA from enduring permanent damage while at the same time, regulating gene expression in reversible and plastic ways. It is a natural and dynamic process that needs continuous regulation for our bodies to function properly. However, this essential machinery can be disrupted by various factors. This paper will explore the molecular and cellular changes that occur in the brain due to epigenetic dysregulation, and how these changes are correlated to neurodegenerative diseases such as Alzheimer's and Huntington’s disease.
References
Mehler, M. F. (2008). Epigenetics and the nervous system. Annals of Neurology, 64(6),
–617. https://doi.org/10.1002/ana.21595
Kubota, T., Hirasawa Takae, & Miyake, K. (2012). Epigenetic Mechanisms and
Therapeutic Perspectives for Neurodevelopmental Disorders. Pharmaceuticals, 5(4),
–383. https://doi.org/10.3390/ph5040369
MacDonald, W. A. (2012). Epigenetic Mechanisms of Genomic Imprinting: Common
Themes in the Regulation of Imprinted Regions in Mammals, Plants, and Insects.
Genetics Research International, 2012, 1–17. https://doi.org/10.1155/2012/585024
Jakovcevski, M., & Schahram Akbarian. (2012). Epigenetic mechanisms in neurological
disease. Nature Medicine, 18(8), 1194–1204. https://doi.org/10.1038/nm.2828
Jorge Alejandro Alegría-Torres, Baccarelli, A., & Bollati, V. (2011). Epigenetics and
lifestyle. Epigenomics, 3(3), 267–277. https://doi.org/10.2217/epi.11.22
Vivek Kumar Sharma, Mehta, V., & Thakur Gurjeet Singh. (2020). Alzheimer's Disorder:
Epigenetic Connection and Associated Risk Factors. Current Neuropharmacology, 18(8),
–753. https://doi.org/10.2174/1570159x18666200128125641
Clinic, C. (2023). Huntington's Disease: What It Is, Symptoms & Treatment. Cleveland
Clinic. https://my.clevelandclinic.org/health/diseases/14369-huntingtons-disease
Hodges, A., Strand, A. D., Aragaki, A. K., Kuhn, A., Thierry Sengstag, Hughes, G.,
Elliston, L. A., Hartog, C., Goldstein, D. R., Thu, D., Hollingsworth, Z. R., Collin, F.,
Synek, B., Holmans, P. A., Young, A. B., Wexler, N. S., Delorenzi, M., Kooperberg, C.,
Augood, S. J., & Richard L.M. Faull. (2006). Regional and cellular gene expression
changes in human Huntington’s disease brain. Human Molecular Genetics, 15(6),
–977. https://doi.org/10.1093/hmg/ddl013
Ross, C. A., & Poirier, M. A. (2004). Protein aggregation and neurodegenerative disease.
Nature Medicine, 10(S7), S10–S17. https://doi.org/10.1038/nm1066
Laetitia Francelle, Lotz, C., Tiago Outeiro, Brouillet, E., & Merienne, K. (2017).
Contribution of Neuroepigenetics to Huntington's Disease. Frontiers in Human
Neuroscience, 11. https://doi.org/10.3389/fnhum.2017.00017
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