Nutritional Status of Sickle Cell Patients: A Literature Review
DOI:
https://doi.org/10.58445/rars.164Keywords:
Sickle Cell Disease, Nutrient Deficiency, Vitamins, MineralsAbstract
Sickle cell disease (SCD) is a lethal, life-long condition characterized by a mutation in the gene that codes for hemoglobin. To alleviate the pain experienced by sickle cell (SC) patients, adequate nutrition levels are vital as deficiencies of vitamins or minerals may cause other symptoms. The objective of this review is to outline the nutrient status of SC patients and propose research areas where further study is needed. This review summarizes twelve primary research papers that measured the level of vitamins A, C, D, E, B-2, B-6, B-12, folate, magnesium, iron, zinc, and copper in SC patients. The majority of SC patients had suboptimal vitamin A levels and were vitamin D deficient. Their zinc and vitamins B-6, C, and E levels were adequate, while their folate, copper, and iron levels were elevated. There were notable differences in some of the measurement methods used for the same nutrient levels. There is more research needed to find the optimal amount of vitamin A supplement for SC patients, and the effect of zinc supplementation on copper levels and the cause of low zinc levels in SC patients remains unexplored.
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