Investigation of the Interactions and Benefits of Music Therapy and TREM2 in the Reduction of Alzheimer’s Disease
DOI:
https://doi.org/10.58445/rars.1602Keywords:
Alzheimer's Disease, music therapy, TREM2Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss, driven by complex interactions between genetic factors and environmental influences. Despite advancement in the understanding of AD, therapeutic approaches are limited. Among the potential therapeutic approaches, there are triggering receptor expressed on myeloid cells 2 (TREM2) and music therapy. TREM2 has been identified as a key genetic factor and potential therapeutic target for AD. TREM2, predominantly expressed in central nervous system (CNS) microglia, is involved in crucial microglial functions such as proliferation and phagocytosis. TREM2 also plays a role in regulating inflammatory responses and cell signaling pathways. Meanwhile music therapy has emerged as a promising non-pharmacological approach for managing AD symptoms, with evidence suggesting it can improve cognitive function, emotional well-being, and overall quality of life. This review evaluates both non-pharmacological and pharmacological treatments for AD, focusing on music therapy and the role of TREM2. We will discuss the current evidence supporting them and their potential mechanisms. Additionally, the review will explore a proposed connection between music therapy and TREM2, promoting further research into their combined effects. By providing a comprehensive overview, this review seeks to guide future studies and enhance therapeutic approaches for Alzheimer's disease.
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