Novel Immunotherapy Adjuvant
Oncolytic Viral Therapy
DOI:
https://doi.org/10.58445/rars.1572Keywords:
cancer, Immunotherapy, Viral TherapyAbstract
Through the rise in novel technology in the realm of cancer, science has taken a significant step forward in treatment. Despite such advancements, struggles lie ahead: tumor relapse remains a prevalent issue due to the lack of durable treatments that combat the return of cancer. The following discusses the path of using immunotherapy and oncolytic viral therapy in conjunction to mediate where the other lacks. I propose deriving viruses to target cancer-specific receptors consisting of vaccinated viral antigens to activate an immune response. This approach allows for long-term durability and patient-specific treatment, thus reaching more populations.
References
Abramson Cancer Center. (n.d.). Hormone Receptor Positive (HR+) Breast Cancer. Penn Medicine. https://www.pennmedicine.org/cancer/types-of-cancer/breast-cancer/types-of-breast-cancer/hormone-positive-breast-cancer
American Lung Association. (2022, November 17). Lung Cancer Symptoms and Diagnosis. American Lung Association. https://www.lung.org/lung-health-diseases/lung-disease-lookup/lung-cancer/symptoms-diagnosis
ASCO. (2021, December). Side Effects of Chemotherapy. Cancer.Net. https://www.cancer.net/navigating-cancer-care/how-cancer-treated/chemotherapy/side-effects-chemotherapy
Astellas. (2023, April 22). Discover Claudin18.2, a novel biomarker in the advanced gastric cancer landscape. Astellas. https://www.gastriccancerbiomarkers.com/?utm_medium=cpc&utm_source=google&utm_campaign=Unbranded+DSE_General_3516&utm_term=gastric%20cancer%20biomarker&gclid=CjwKCAjw29ymBhAKEiwAHJbJ8olF8BVZio5FePgzWb0nFogELewq3Hl8Pco9JF_EAR0xAEQaDGHM9hoCpoUQAvD_BwE&gclsrc
Bell, J. C. (n.d.). Immunotherapy: Oncolytic Virus Therapy. Cancer Research Institute. https://www.cancerresearch.org/treatment-types/oncolytic-virus-therapy
Boldt, C., & Sharma, P. (2020, September 30). Why doesn't immunotherapy work for everyone? MD Anderson Cancer Center. https://www.mdanderson.org/cancerwise/why-doesnt-immunotherapy-work-for-everyone.h00-159385101.html
Cao, G. (n.d.). The Oncolytic Virus in Cancer Diagnosis and Treatment. Frontiers, 10. https://doi.org/10.3389/fonc.2020.01786
Centers for Disease Control and Prevention. (2023, June 13). FastStats - Immunization. CDC. http://cdc.gov/nchs/fastats/immunize.htm
Dobosz, P. (2019, December 17). The Intriguing History of Cancer Immunotherapy - PMC. NCBI. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928196/#B4
Dunn, G. P. (n.d.). Immunotherapy: Cancer Vaccines. Cancer Research Institute. https://www.cancerresearch.org/treatment-types/cancer-vaccines
Grossberg, H. (2019, January 10). A suicide switch for CAR-T. IQVIA. https://www.iqvia.com/blogs/2019/01/a-suicide-switch-for-car-t
Hajdu, S. I. (2010, Ocotober 19). A note from history: Landmarks in history of cancer, part 1. ACS Journals, 117(5), 1097-1102. https://doi.org/10.1002/cncr.25553
National Cancer Institute. (2018, February 9). Using Oncolytic Viruses to Treat Cancer - NCI. National Cancer Institute. https://www.cancer.gov/news-events/cancer-currents-blog/2018/oncolytic-viruses-to-treat-cancer
National Cancer Institute. (2019, September 24). Immunotherapy for Cancer - NCI. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/types/immunotherapy
National Cancer Institute. (2019, September 24). Monoclonal Antibodies - NCI. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/monoclonal-antibodies
National Cancer Institute. (2022, April 7). Immune Checkpoint Inhibitors - NCI. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/checkpoint-inhibitors
Physician Query Data. (2020, August 19). Cancer Screening Overview (PDQ®)–Patient Version. National Cancer Institute. https://www.cancer.gov/about-cancer/screening/patient-screening-overview-pdq
SEER Training Modules. (n.d.). Combination Treatments. SEER Training. https://training.seer.cancer.gov/treatment/combination/
The American Cancer Society medical and editorial content team. (2019, December 27). How Radiation Therapy Is Used to Treat Cancer. American Cancer Society. https://www.cancer.org/cancer/managing-cancer/treatment-types/radiation/basics.html
Yu, B., Shi, Q., Belk, J. A., Davis, M. M., Stapathy, A. T., & Chang, H. Y. (2022, December 22). Engineered cell entry links receptor biology with single-cell genomics. https://doi.org/10.1016/j.cell.2022.11.016
Downloads
Posted
Categories
License
Copyright (c) 2024 Debohuti Sahu
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.