Preprint / Version 1

Doping Agents In Sports

##article.authors##

  • ZhongYu Richard Xun Kristin School

DOI:

https://doi.org/10.58445/rars.1553

Keywords:

Chemistry, Analytical Chemistry Doping, Drug Detection, Anabolic Androgenic Steroids

Abstract

Even in 2024, doping in sports remains a significant concern, posing challenges regarding health, ethics, and equity. This paper provides an exploration of doping agents, with a focus on their chemistry, mechanisms of action and methods of their detection. The structures and modes-of-action of testosterone derivates are discussed, and the analytical methods of gas chromatography coupled with mass spectrometry, gas chromatography coupled with tandem mass spectrometry, gas chromatography/combustion/isotope ratio mass spectrometry, and liquid chromatography are introduced. The paper concludes with a discussion of ways in which users of doping agents attempt to avoid detection and introduces the emerging field of gene doping.

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