How Aging Works and How To Stop It
Aging is a concept familiar to all of us. It claims the most lives yearly and weakens us severely as we get older. Aging itself does not “kill” people, rather, it weakens our immune systems until they stop working well enough to protect us from diseases. This is why conditions like Alzheimer’s or dementia become much more deadly at old age. Currently, modern medicine is working on fixing the problems caused by aging, but not aging itself. But by stopping the aging process, many diseases such as Alzheimer’s, cardiovascular disease, and dementia would be solved in the process as well. In addition, staying youthful also has the benefit of being less susceptible to diseases that aren’t related with age, as your body and immune system are overall stronger. With recent scientific breakthroughs, new potential therapies in the fight against aging have been discovered.
Aging: Too Much Telomerase Can Be as Bad as Too Little - Scientific American Blog Network. https://blogs.scientificamerican.com/guest-blog/aging-too-much-telomerase-can-be-as-bad-as-too-little/. Accessed 11 Sept. 2022.
Callaway, Ewen. “Telomerase Reverses Ageing Process.” Nature, Nov. 2010, doi:10.1038/news.2010.635.
Chini, Claudia C. S., et al. “CD38 Ecto-Enzyme in Immune Cells Is Induced during Aging and Regulates NAD+ and NMN Levels.” Nature Metabolism, vol. 2, no. 11, Nov. 2020, pp. 1284–304, doi:10.1038/s42255-020-00298-z.
Covarrubias, Anthony J., et al. “NAD+ Metabolism and Its Roles in Cellular Processes during Ageing.” Nature Reviews. Molecular Cell Biology, vol. 22, no. 2, Feb. 2021, pp. 119–41, doi:10.1038/s41580-020-00313-x.
Imai, Shin-ichiro, and Leonard Guarente. “NAD+ and Sirtuins in Aging and Disease.” Trends in Cell Biology, vol. 24, no. 8, Aug. 2014, pp. 464–71, doi:10.1016/j.tcb.2014.04.002.
Lu, Yuancheng, et al. “Reprogramming to Recover Youthful Epigenetic Information and Restore Vision.” Nature, vol. 588, no. 7836, Dec. 2020, pp. 124–29, doi:10.1038/s41586-020-2975-4.
Mercken, Evi M., et al. “Of Mice and Men: The Benefits of Caloric Restriction, Exercise, and Mimetics.” Ageing Research Reviews, vol. 11, no. 3, July 2012, pp. 390–98, doi:10.1016/j.arr.2011.11.005.
Okabe, Keisuke, et al. “Implications of Altered NAD Metabolism in Metabolic Disorders.” Journal of Biomedical Science, vol. 26, no. 1, May 2019, p. 34, doi:10.1186/s12929-019-0527-8.
Rajman, Luis, et al. “Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.” Cell Metabolism, vol. 27, no. 3, Mar. 2018, pp. 529–47, doi:10.1016/j.cmet.2018.02.011.
Sachdev, Esha, et al. “PARP Inhibition in Cancer: An Update on Clinical Development.” Targeted Oncology, vol. 14, no. 6, Dec. 2019, pp. 657–79, doi:10.1007/s11523-019-00680-2.
Sultani, G., et al. “NAD+ : A Key Metabolic Regulator with Great Therapeutic Potential.” Journal of Neuroendocrinology, vol. 29, no. 10, Oct. 2017, doi:10.1111/jne.12508.
Telomerase: Definition, Function, Structure and Cancer | Biology Dictionary. https://biologydictionary.net/telomerase/. Accessed 29 Aug. 2022.
Verdin, Eric. “NAD+ in Aging, Metabolism, and Neurodegeneration.” Science, vol. 350, no. 6265, Dec. 2015, pp. 1208–13, doi:10.1126/science.aac4854.
Wang, Ling-Fang, et al. “CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD+/Sirt1 Signaling Pathway.” Frontiers in Physiology, vol. 10, Sept. 2019, p. 1125, doi:10.3389/fphys.2019.01125.
Copyright (c) 2023 Naren Selvam
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.