Autism From A Neurobiological Perspective
A Disorder, Not A Disease
DOI:
https://doi.org/10.58445/rars.1521Keywords:
Neuroscience, Autism Spectrum Disorder, Therapies, ASD Diagnosis, NeurobiologyAbstract
This paper focuses on eradicating stigmas related to Autism Spectrum Disorder (ASD), particularly addressing the misconception that ASD is a disease requiring a cure rather than a neurodevelopmental disorder with various behaviors and symptoms that can be managed through specific and personalized interventions. The current societal approach often frames autism as a condition to be "fixed," that fails to acknowledge the spectrum's complexity. This paper seeks to challenge these views by delving into the neurobiological factors of ASD, including genetics, neuroanatomy, and brain function. Through a comprehensive analysis of these factors, the goal is to promote a more nuanced understanding of ASD that respects the individuality of those on the spectrum. By shifting the focus from "curing" autism to understanding its variability, this paper aims to propose more ethical, effective, and representative treatment approaches, fostering greater acceptance and inclusion within society.
References
Abdulamir, H. A., Abdul-Rasheed, O. F., & Abdulghani, E. A. (2018). Serotonin and serotonin Transporter levels in autistic children. Saudi Medical Journal, 39(5), 487–494. https://doi.org/10.15537/smj.2018.5.21751
Apte, M., & Kumar, A. (2023). Correlation of mutated gene and signaling pathways in ASD. IBRO neuroscience reports, 14, 384–392. https://doi.org/10.1016/j.ibneur.2023.03.011
Almalki N. S. (2022). Using the Model, Lead, and Test Technique and "GoTalk NOW" App to Teach Children With Intellectual and Developmental Delays to Correctly Request. Frontiers in psychology, 12, 811510. https://doi.org/10.3389/fpsyg.2021.811510
Bai, C., Wang, Y., Zhang, Y., Wang, X., Chen, Z., Yu, W., Zhang, H., Li, X., Zhu, K., Wang, Y., & Zhang, T. (2023). Abnormal gray matter volume and functional connectivity patterns in social cognition-related brain regions of young children with autism spectrum disorder. Autism research : official journal of the International Society for Autism Research, 16(6), 1124–1137. https://doi.org/10.1002/aur.2936
Bakshi, A., & Tadi, P. (2022). Biochemistry, Serotonin. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK560856/
Child Mind Institute. (n.d.). Why autism diagnoses are often delayed. Child Mind Institute. https://childmind.org/article/why-autism-diagnoses-are-often-delayed/
Cleveland Clinic. (n.d.). Fragile X syndrome.
https://my.clevelandclinic.org/health/diseases/5476-fragile-x-syndrome
Coelho-Medeiros, M. E., Bronstein, J., Aedo, K., Pereira, J. A., Arraño, V., Perez, C. A.,
Valenzuela, P. M., Moore, R., Garrido, I., & Bedregal, P. (2019). M-CHAT-R/F
Validation as a screening tool for early detection in children with autism
spectrum disorder. Validación del M-CHAT-R/F como instrumento de tamizaje
para detección precoz en niños con trastorno del espectro autista. Revista
chilena de pediatria, 90(5), 492–499. https://doi.org/10.32641/rchped.v90i5.703
Courchesne, E., Campbell, K., & Solso, S. (2011). Brain growth across the life span in autism: age-specific changes in anatomical pathology. Brain research, 1380, 138–145. https://doi.org/10.1016/j.brainres.2010.09.101
Conner, C. M., Cramer, R. D., & McGonigle, J. J. (2019). Examining the Diagnostic
Validity of Autism Measures Among Adults in an Outpatient Clinic Sample.
Autism in adulthood : challenges and management, 1(1), 60–68.
https://doi.org/10.1089/aut.2018.0023
Dingemans, A.J.M., Truijen, K.M.G., van de Ven, S. et al. The phenotypic spectrum and
genotype-phenotype correlations in 106 patients with variants in major autism
gene CHD8. Transl Psychiatry 12, 421 (2022).
https://doi.org/10.1038/s41398-022-02189-1
Duvall, R. M. (2020). The relationship between autism and the multiple intelligences
theory: Identifying patterns in learning for educational purposes (Honors thesis). Digital
Commons. https://encompass.eku.edu/honors_theses/715
Ebert, D. H., & Greenberg, M. E. (2013). Activity-dependent neuronal signalling and
autism spectrum disorder. Nature, 493(7432), 327–337.
https://doi.org/10.1038/nature11860
Fishman, I., Keown, C. L., Lincoln, A. J., Pineda, J. A., & Müller, R. A. (2014).
Atypical cross talk between mentalizing and mirror neuron networks in
autism spectrum disorder. JAMA psychiatry, 71(7), 751–760.
https://doi.org/10.1001/jamapsychiatry.2014.83
Ganz J. B. (2015). AAC Interventions for Individuals with Autism Spectrum Disorders:
State of the Science and Future Research Directions. Augmentative and
alternative communication (Baltimore, Md. : 1985), 31(3), 203–214.
https://doi.org/10.3109/07434618.2015.1047532
Gasiewski, K., Weiss, M. J., Leaf, J. B., & Labowitz, J. (2021). Collaboration
between Behavior Analysts and Occupational Therapists in Autism Service
Provision: Bridging the Gap. Behavior analysis in practice, 14(4), 1209–1222.
https://doi.org/10.1007/s40617-021-00619-y
Geschwind D. H. (2011). Genetics of autism spectrum disorders.
Trends in cognitive sciences, 15(9), 409–416. https://doi.org/10.1016/j.tics.2011.07.003
Gzielo, K., & Nikiforuk, A. (2021). Astroglia in Autism Spectrum Disorder.
International journal of molecular sciences, 22(21), 11544.
https://doi.org/10.3390/ijms222111544
Ha, S., Sohn, I. J., Kim, N., Sim, H. J., & Cheon, K. A. (2015). Characteristics of Brains
in Autism Spectrum Disorder: Structure, Function and Connectivity across the Lifespan.
Experimental neurobiology, 24(4), 273–284. https://doi.org/10.5607/en.2015.24.4.273
Hashem, S., Nisar, S., Bhat, A. A., Yadav, S. K., Azeem, M. W., Bagga, P., Fakhro, K.,
Reddy, R., Frenneaux, M. P., & Haris, M. (2020). Genetics of structural and
functional brain changes in autism spectrum disorder. Translational psychiatry, 10(1), 229. https://doi.org/10.1038/s41398-020-00921-3
Hirota, T., & King, B. H. (2023). Autism Spectrum Disorder: A Review. JAMA, 329(2),
–168. https://doi.org/10.1001/jama.2022.23661
Hours, C., Recasens, C., & Baleyte, J. M. (2022). ASD and ADHD Comorbidity: What Are
We Talking About?. Frontiers in psychiatry, 13, 837424.
https://doi.org/10.3389/fpsyt.2022.837424
Hua, X., Thompson, P. M., Leow, A. D., Madsen, S. K., Caplan, R., Alger, J. R.,
O'Neill, J., Joshi, K., Smalley, S. L., Toga, A. W., & Levitt, J. G. (2013). Brain
growth rate abnormalities visualized in adolescents with autism. Human brain mapping,
(2), 425–436. https://doi.org/10.1002/hbm.21441
Inside the Autism Brain Channel: The Transmitter. (2020, October 9). [Video].
YouTube. https://www.youtube.com/watch?v=iJMWATYG9Zc
Kilner, J. M., & Lemon, R. N. (2013). What we know currently about mirror
neurons. Current biology : CB, 23(23), R1057–R1062.
https://doi.org/10.1016/j.cub.2013.10.051
Kim, S. H., Joseph, R. M., Frazier, J. A., O'Shea, T. M., Chawarska, K., Allred, E. N.,
Leviton, A., Kuban, K. K., & Extremely Low Gestational Age Newborn
(ELGAN) Study Investigators (2016). Predictive Validity of the Modified
Checklist for Autism in Toddlers (M-CHAT) Born Very Preterm. The Journal of
pediatrics, 178, 101–107.e2. https://doi.org/10.1016/j.jpeds.2016.07.052
King, M., Romski, M., & Sevcik, R. A. (2020). Growing up with AAC in the digital age: a longitudinal profile of communication across contexts from toddler to teen. Augmentative and alternative communication (Baltimore, Md. : 1985), 36(2), 128–141. https://doi.org/10.1080/07434618.2020.1782988
Kleinman, J. M., Robins, D. L., Ventola, P. E., Pandey, J., Boorstein, H. C., Esser, E. L., Wilson, L. B., Rosenthal, M. A., Sutera, S., Verbalis, A. D., Barton, M., Hodgson, S., Green, J., Dumont-Mathieu, T., Volkmar, F., Chawarska, K., Klin, A., & Fein, D. (2008). The modified checklist for autism in toddlers: a follow-up study investigating the early detection of autism spectrum disorders. Journal of autism and developmental disorders, 38(5), 827–839. https://doi.org/10.1007/s10803-007-0450-9
Kyle, S. M., Vashi, N., & Justice, M. J. (2018). Rett syndrome: a neurological
disorder with metabolic components. Open biology, 8(2), 170216.
https://doi.org/10.1098/rsob.170216
Lamanna, J., & Meldolesi, J. (2024). Autism spectrum disorder: Brain areas involved,
neurobiological mechanisms, diagnoses, and therapies. International Journal
of Molecular Sciences, 25(4), 2423. https://doi.org/10.3390/ijms25042423
Leaf, J. B., Cihon, J. H., Leaf, R., McEachin, J., Liu, N., Russell, N., Unumb, L., Shapiro,
S., & Khosrowshahi, D. (2022). Concerns About ABA-Based Intervention:
An Evaluation and Recommendations. Journal of autism and developmental disorders,
(6), 2838–2853. https://doi.org/10.1007/s10803-021-05137-y
Leblanc, L. A., Esch, J., Sidener, T. M., & Firth, A. M. (2006). Behavioral language
interventions for children with autism: comparing applied verbal behavior
and naturalistic teaching approaches. The Analysis of verbal behavior, 22(1), 49–60.
https://doi.org/10.1007/BF03393026
LeClerc, S., & Easley, D. (2015). Pharmacological therapies for autism spectrum
disorder: a review. P & T : a peer-reviewed journal for formulary
management, 40(6), 389–397. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450669/
Lordan, R., Storni, C., & De Benedictis, C. A. (2021). Autism spectrum disorders:
Diagnosis and treatment. In A. M. Grabrucker (Ed.), Autism spectrum disorders [Internet]
(Chapter 2). Exon Publications. https://www.ncbi.nlm.nih.gov/books/NBK573609/
Mandic-Maravic, V., Grujicic, R., Milutinovic, L., Munjiza-Jovanovic, A., &
Pejovic-Milovancevic, M. (2022). Dopamine in Autism Spectrum
Disorders-Focus on D2/D3 Partial Agonists and Their Possible Use in
Treatment. Frontiers in psychiatry, 12, 787097.
https://doi.org/10.3389/fpsyt.2021.787097
Marco, E. J., Hinkley, L. B., Hill, S. S., & Nagarajan, S. S. (2011). Sensory processing in
autism: a review of neurophysiologic findings. Pediatric research, 69(5 Pt 2), 48R–54R.
https://doi.org/10.1203/PDR.0b013e3182130c54
Marotta, R., Risoleo, M. C., Messina, G., Parisi, L., Carotenuto, M., Vetri, L., & Roccella,
M. (2020). The Neurochemistry of Autism. Brain sciences, 10(3), 163.
https://doi.org/10.3390/brainsci10030163
Maseri, M., Mamat, M., Yew, H. T., & Chekima, A. (2021). The Implementation of
Application Software to Improve Verbal Communication in Children with
Autism Spectrum Disorder: A Review. Children (Basel, Switzerland), 8(11), 1001.
https://doi.org/10.3390/children8111001
MedlinePlus Genetics. (n.d.). Autism spectrum disorder. National Library of Medicine.
https://medlineplus.gov/genetics/condition/autism-spectrum-disorder/
Nadeem, M. S., Murtaza, B. N., Al-Ghamdi, M. A., Ali, A., Zamzami, M. A., Khan,
J. A., Ahmad, A., Rehman, M. U., & Kazmi, I. (2021). Autism - A Comprehensive
Array of Prominent Signs and Symptoms. Current pharmaceutical design, 27(11),
–1433. https://doi.org/10.2174/1381612827666210120095829
National Institute of Neurological Disorders and Stroke. (n.d.). Rett syndrome. National
Institutes of Health. https://www.ninds.nih.gov/health-information/disorders/rett-syndrome
National Institute on Deafness and Other Communication Disorders. (2020). Autism
spectrum disorder: Communication problems in children. National Institutes of Health.
https://www.nidcd.nih.gov/health/autism-spectrum-disorder-communication-problems-ch
ildren
Neuroscience Transmissions. (2023, May 25). The neuroscience of Autism ft. 12tone
[Video]. YouTube. https://www.youtube.com/watch?v=275TqUelUX0
Posar, A., Resca, F., & Visconti, P. (2015). Autism according to diagnostic and statistical
manual of mental disorders 5(th) edition: The need for further improvements. Journal of
pediatric neurosciences, 10(2), 146–148. https://doi.org/10.4103/1817-1745.159195
Paul R. (2008). Interventions to improve communication in autism. Child and adolescent
psychiatric clinics of North America, 17(4), 835–x.
https://doi.org/10.1016/j.chc.2008.06.011
Robins, D. L., Casagrande, K., Barton, M., Chen, C. M., Dumont-Mathieu, T., & Fein,
D. (2014). Validation of the modified checklist for Autism in toddlers,
revised with follow-up (M-CHAT-R/F). Pediatrics, 133(1), 37–45.
https://doi.org/10.1542/peds.2013-1813
Rothwell, P. E., Fuccillo, M. V., Maxeiner, S., Hayton, S. J., Gokce, O., Lim, B. K.,
Fowler, S. C., Malenka, R. C., & Südhof, T. C. (2014). Autism-associated
neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors.
Cell, 158(1), 198–212. https://doi.org/10.1016/j.cell.2014.04.045
Sharifi, O., & Yasui, D. H. (2021). The Molecular Functions of MeCP2 in Rett
Syndrome Pathology. Frontiers in genetics, 12, 624290.
https://doi.org/10.3389/fgene.2021.624290
Tian, J., Gao, X., & Yang, L. (2022). Repetitive Restricted Behaviors in Autism
Spectrum Disorder: From Mechanism to Development of Therapeutics.
Frontiers in neuroscience, 16, 780407. https://doi.org/10.3389/fnins.2022.780407
University of Maryland School of Medicine. (2023, January 24). New research shows
how brain inflammation in children may cause neurological disorders such as autism or
Schizophrenia.https://www.medschool.umaryland.edu/news/2023/new-research-shows-h
Ow-brain-inflammation-in-children-may-cause-neurological-disorders-such-as-autism-or
-schizophrenia.html
Virués-Ortega J. (2010). Applied behavior analytic intervention for autism in early
childhood: a meta-analysis, meta-regression, and dose-response meta-analysis of
multiple outcomes. Clinical psychology review, 30(4), 387–399.
https://doi.org/10.1016/j.cpr.2010.01.008
Volkmar, F. R., & Reichow, B. (2013). Autism in DSM-5: progress and challenges.
Molecular autism, 4(1), 13. https://doi.org/10.1186/2040-2392-4-13
Werkhoven, S., Anderson, J. H., & Robeyns, I. A. M. (2022). Who benefits from
Diagnostic labels for developmental disorders? Developmental medicine
and child neurology, 64(8), 944–949. https://doi.org/10.1111/dmcn.15177
Wilkinson, M., Wang, R., van der Kouwe, A., & Takahashi, E. (2016). White and gray
matter fiber pathways in autism spectrum disorder revealed by ex vivo diffusion MR
tractography. Brain and behavior, 6(7), e00483. https://doi.org/10.1002/brb3.483
Wulffaert, J., Van Berckelaer-Onnes, I. A., & Scholte, E. M. (2009). Autistic disorder
Symptoms in Rett syndrome. Autism: the international journal of research and
practice, 13(6), 567–581. https://doi.org/10.1177/1362361309338184
Xavier S. D. (2021). The relationship between autism spectrum disorder and sleep.
Sleep science (Sao Paulo, Brazil), 14(3), 193–195.
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