What is Huntington's Disease and How We Can Use Virtual Reality to Overcome Difficulties?
DOI:
https://doi.org/10.58445/rars.1431Keywords:
Huntington’s Disease (HD), virtual reality, therapyAbstract
Huntington's disease, or HD, is a rare, neurodegenerative disease that causes the progressive breakdown (degeneration) of nerve cells in the brain. The molecular cause of HD is a mutation in the HTT gene, which codes for the Huntingtin protein. A part of the gene segment contains the repeating base pairs CAG, as illustrated. Normally, the base pairs CAG repeat 10-35 times, however in an individual with HD the segment repeats 36-120+ times. This produces an abnormally long protein. Fragments get cut off into toxic fragments that bind together and accumulate in neurons, damaging them. This paper specifically looks at the role of miRNAs in the pathogenesis of HD and the development of a novel application designed to provide comprehensive support to HD patients and the history behind HD. This application offers virtual, interactive physical therapy to alleviate physical symptoms while simultaneously monitoring disease progression.
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