Correlations Between Creutzfeldt-Jakob Disease (CJD) and the Endocrine System
DOI:
https://doi.org/10.58445/rars.1271Keywords:
Creutzfeldt-Jakob disease (CJD), Prion diseases, Neurodegenerative disorders, Endocrine system, Hormone secretionAbstract
Creutzfeldt-Jakob disease (CJD) is a rare, degenerative brain disorder caused by abnormal proteins referred to as “prions'' that accumulate in one’s brain. This life-threatening disease leads to individuals contracting symptoms such as memory loss, personality changes, and impaired judgment. As the disease progresses, the body starts experiencing blindness, weakness, and involuntary movements that typically lead to death within six to eight months. There are three primary divisions: Sporadic Creutzfeldt-Jakob disease (sCJD), Familial Creutzfeldt-Jakob disease (fCJD), and Acquired Creutzfeldt-Jakob disease (aCJD).
This is the first study to explore and recognize the correlation of CJD on the human body's endocrine system. By analyzing MRI scans and plotting data to create graphs, the research team has identified notable disruptions in the normal secretion of hormones from the hypothalamus and pituitary gland. This shows significant implications for the reproductive health, metabolic function, and overall endocrine balance of affected individuals. Specifically, the disease can result in delayed or altered puberty, infertility, and metabolic dysfunction.
Upon discovering this pattern, the study moved forward with a focus on what factors are contributing to the disruptions in hormone secretion. The research team then created a simulation using Python code to model trends associated with current CJD cases and predicted several variables in the succeeding years. They compared the trends that were modeled to the new trends associated with implementing our potential methods for mitigating CJD.
References
“Acquired CJD: Pathology: School of Medicine: Case Western Reserve University.” Pathology | School of Medicine | Case Western Reserve University, 7 Mar. 2022, case.edu/medicine/pathology/divisions/national-prion-disease-pathology-surveilla nce-center/human-prion-disease/acquired-cjd.
“Acquired CJD: Pathology: School of Medicine: Case Western Reserve University.” Pathology | School of Medicine | Case Western Reserve University, 7 Mar. 2022, case.edu/medicine/pathology/divisions/national-prion-disease-pathology-surveilla nce-center/human-prion-disease/acquired-cjd.
Author links open overlay panelKevin W. Boyack a, et al. “Characterizing In-Text Citations in Scientific Articles: A Large-Scale Analysis.” Journal of Informetrics, Elsevier, 1 Dec. 2017,
www.sciencedirect.com/science/article/abs/pii/S1751157717303516.
“Creutzfeldt-Jakob Disease.” Alzheimer’s Disease and Dementia,
www.alz.org/alzheimers-dementia/what-is-dementia/types-of-dementia/creutzfeld t-jakob-disease#:~:text=Through%20a%20process%20 scientists%20 don,difficulty%20walking%20and%20food%20 changes. Accessed 16 Mar. 2024.
“Creutzfeldt-Jakob Disease.” Mayo Clinic, Mayo Foundation for Medical Education and Research,
www.mayoclinic.org/diseases-conditions/creutzfeldt-jakob-disease/symptoms-ca uses/syc-20371226. Accessed 16 Mar. 2024.
Johnson, Matthew G, et al. “Familial Creutzfeldt-Jakob Disease Cluster among an African American Family.” Journal of Public Health Management and Practice : JPHMP, U.S. National Library of Medicine, 2017,
www.ncbi.nlm.nih.gov/pmc/articles/PMC6947528/.
L;, Männistö PT;Laakso ML;Järvinen A;Rago. “Effects of Central and Peripheral Type Benzodiazepine Ligands on Growth Hormone and Gonadotropin Secretion in Male Rats.” Pharmacology & Toxicology, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/1326109/#:~:text=Clonazepam%20 increased%20 growth%20 hormone%20 levels,%2Fkg)%20was%20not%20 effective. Accessed 16 Mar. 2024.
“Misfolded Proteins Are Biomarkers for Brain Diseases: Amprion.” Amprion DX, 6 Mar. 2024, ampriondx.com/misfolded-proteins/#:~:text=Misfolded%20 proteins%20are%20 soluble%20 nanoparticles,cells%20leading%20to%20call%20 death.
“NCI Dictionary of Cancer Terms.” National Cancer Institute,
www.cancer.gov/publications/dictionaries/cancer-terms/def/gonadotropin-releasi ng-hormone. Accessed 16 Mar. 2024.
panel, Author links open overlay. “The Services.” The Lancet, Elsevier, 8 Sept. 2003, www.sciencedirect.com/science/article/abs/pii/S0140673601569937.
professional, Cleveland Clinic medical. “Gonadotropin-Releasing Hormone (GnRH): Purpose & Testing.” Cleveland Clinic,
my.clevelandclinic.org/health/body/22525-gonadotropin-releasing-hormone. Accessed 16 Mar. 2024.
professional, Cleveland Clinic medical. “Gonadotropin-Releasing Hormone (GnRH): Purpose & Testing.” Cleveland Clinic,
my.clevelandclinic.org/health/body/22525-gonadotropin-releasing-hormone. Accessed 16 Mar. 2024.
Seethamma Gari, Kranthi K. ``Creutzfeldt Jakob Disease.” StatPearls [Internet]., U.S. National Library of Medicine, 30 Jan. 2024,
www.ncbi.nlm.nih.gov/books/NBK507860/.
T;, Humbert. “[Neuroendocrine Effects of Benzodiazepines].” Annales Medico-Psychologiques, U.S. National Library of Medicine,
pubmed.ncbi.nlm.nih.gov/8085710/#:~:text=While%20benzodiazepines%20produ ce%20inconsistent%20effects,to%20stressful%20and%20pharmacological%20sti muli.
https://pubmed.ncbi.nlm.nih.gov/18384456/#:~:text=Benzodiazepines%20(BZDs) %20remain%20important%20agents,repetitive%20and%20alcohol%20withdrawal% 20seizures. Accessed 16 Mar. 2024.
“N-Type Calcium Channel - an Overview | ScienceDirect Topics.” Www.sciencedirect.com,
www.sciencedirect.com/topics/neuroscience/n-type-calcium-channel#:~:text=Le vetiracetam%20inhibits%20excitatory%20neurotransmission%20at.
NHS. “About Levetiracetam.” Nhs.uk, 13 May 2022,
www.nhs.uk/medicines/levetiracetam/about-levetiracetam/#:~:text=Levetiraceta m%20is%20a%20medicine%20used.
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