Preprint / Version 1

The effects of shift work induced circadian disruption on human health and its countermeasures

##article.authors##

  • Mahiti Kandukuri Polygence student

DOI:

https://doi.org/10.58445/rars.1259

Keywords:

shift work, circadian disruption, health

Abstract

This review delves into the effects of shift work-induced disruptions to circadian rhythms on human physiology and cognition. By explaining the complex connections between circadian rhythms and various physiological systems, including cardiovascular, digestive, reproductive, nervous, and endocrine systems, it shows that circadian disruption goes beyond just bad sleep. Additionally, this paper explores potential countermeasures, such as light exposure, melatonin administration, sleep hygiene practices, strategic napping, and pharmacological interventions, offering viable strategies to mitigate the adverse effects of shift work. Through comprehensive understanding and targeted interventions, this research aims to enhance occupational health and well-being. 

References

Wu, Q-J.; Sun, H.; Wen, Z-Y.; Zhang, M.; Wang, H-Y.; He, X-H.; Jiang, Y-T.; Zhao, Y-H. Shift work and health outcomes: an umbrella review of systematic reviews and meta-analyses of epidemiological studies. JCSM. 2022, 18 (2), 653-662. DOI: 10.5664/jcsm.9642.

Richards, J.; Gumz, M. L. Advances in understanding the peripheral circadian clocks. FASEB J. 2012, 26 (9), 3602-3613. DOI: 10.1096/fj.

Vitaterna, M.H; Takahashi, J.S; Turek, F.W. Overview of circadian rhythms. Alcohol Res Health. 2001, 25 (2), 85-93. PMID: 11584554; PMCID: PMC6707128.

Abbott, K. S.; Queener, H. M.; Ostrin, L. A. The ipRGC-Driven Pupil Response with Light Exposure, Refractive Error, and Sleep. Optometry and Vision Science. 2018, 95 (4) 323-331. DOI: 10.1097/OPX.0000000000001198

Andreani, T.S.; Itoh, T.Q.; Yildirim, E.; Hwangbo, D.S.; Allada, R. Genetics of Circadian Rhythms. Sleep Med Clin. 2015, 10 (4) 413-421. DOI: 10.1016/j.jsmc.2015.08.007

Bae, K.; Jin, X.; Maywood, E. S.; Hastings, M. H.; Reppert, S. M.; Weaver, D. R.; Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock. Neuron. 2001, 30 (2) 525-536. DOI: 10.1016/S0896-6273(01)00302-6

Wickwire, E. M.; Geiger-Brown, J.; Scharf, S. M.; Drake, C. L.; Shift Work and Shift Work Sleep Disorder: Clinical and Organizational Perspectives. Chest. 2017, 151 (5) 1156-1172. DOI: 10.1016/j.chest.2016.12.007.

Boivin, D.B.; Boudreau, P. Impacts of shift work on sleep and circadian rhythms. Pathologie Biologie. 2014, 62 (5) 292-301. DOI: 10.1016/j.patbio.2014.08.001

Mohd Azmi, N. A. S.; Juliana, N.; Azmani, S.; Mohd Effendy, N.; Abu, I. F.; Mohd Fahmi Teng, N. I.; Das, S. Cortisol on Circadian Rhythm and Its Effect on Cardiovascular System. Int J Environ Res Public Health. 2021, 18 (2) 676. DOI: 10.3390/ijerph18020676

Boivin, D. B.; Tremblay, G. M.; James, F. O. Working on atypical schedules. Sleep Medicine. 2007, 8 (6) 578-589. DOI: 10.1016/j.sleep.2007.03.015.

Boivin, D. B.; Boudreau, P.; Tremblay, G. M. Phototherapy and orange-tinted goggles for night-shift adaptation of police officers on patrol. Chronobiol Int. 2012, 29 (5) 629-640. DOI: 10.3109/07420528.2012.675252

Black, N.; D'Souza, A.; Wang, Y.; Piggins, H.; Dobrzynski, H.; Morris, G.; Boyett, M. R. Circadian rhythm of cardiac electrophysiology, arrhythmogenesis, and the underlying mechanisms. Heart Rhythm. 2019, 16 (2) 298-307. DOI: 10.1016/j.hrthm.2018.08.026.

Cruz-Topete, D.; Oakley, R. H.; Cidlowski, J. A. Glucocorticoid Signaling and the Aging Heart. Frontiers in Endocrinology. 2020, (11) 1664-2392. DOI: 10.3389/fendo.2020.00347

Takeda, N.; Maemura, K. Circadian Clock and Cardiovascular Disease. J. Cardiol. 2011, 57 (3), 249−256. DOI: 10.1016/j.jjcc.2011.02.00.

Zhang, J.; Chatham, J. C.; Young, M. E. Circadian Regulation of Cardiac Physiology: Rhythms That Keep the Heart Beating. Annu Rev Physiol. 2020, 10 (82) 79-101. DOI: 10.1146/annurev-physiol-020518-114349

Chellappa, S. L.; Vujovic, N.; Williams, J. S.; Scheer, F. A. J. L. Impact of Circadian Disruption on Cardiovascular Function and Disease. Trends Endocrinol Metab. 2019, 30 (10), 767-779. DOI: 10.1016/j.tem.2019.07.008

Fujino, Y.; Iso, H.; Tamakoshi, A.; Inaba, Y.; Koizumi, A.; Kubo, T.; Yoshimura, T. Japanese Collaborative Cohort Study Group. A prospective cohort study of shift work and risk of ischemic heart disease in Japanese male workers. Am J Epidemiol. 2006, 164 (2), 128-35. DOI: 10.1093/aje/kwj185

Vaughn, B. V.; Rotolo, S.; Roth, H. Circadian rhythm and sleep influences on digestive physiology and disorders. ChronoPhysiology and Therapy. 2014, 67-77. DOI: 10.2147/CPT.S44806

Taleb, Z.; Karpowicz, Phillip. Circadian regulation of digestive and metabolic tissues. Am. J. Physiol. Cell Physiol. 2022, 323 (2). DOI: 10.1152/ajpcell.00166.2022

Stephan, F. K.; Swann, J. M.; Sisk, C. L. Anticipation of 24-hr feeding schedules in rats with lesions of the suprachiasmatic nucleus. Behavioral and Neural Biology. 1979, 25 (3), 346-363. DOI: 10.1016/S0163-1047(79)90415-1

Fustin, J. M.; Doi, M.; Yamada, H.; Komatsu, R.; Shimba, S.; Okamura, H. Rhythmic nucleotide synthesis in the liver: temporal segregation of metabolites. Cell Rep. 2012, 1 (4), 341-349. DOI: 10.1016/j.celrep.2012.03.001

Neufeld-Cohen, A.; Robles, M. S.; Aviram, R.; Manella, G.; Adamovich, Y.; Ladeuix, B.; Nir, D.; Rousso-Noori, L.; Kuperman, Y.; Golik, M.; Mann, M.; Asher, G. Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins. PNAS. 2016, 113 (12), 1673-1682. DOI: 10.1073/pnas.1519650113

Jacobi, D.; Liu, S.; Burkewitz, K.; Kory, N.; Knudsen, N. H.; Alexander, R. K.; Unluturk, U.; Li, X.; Kong, X.; Hyde, A. L.; Gangl, M. R.; Mair, W. B.; Lee, C. H. Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness. Cell Metab. 2015, 22 (4), 709-720. DOI: 10.1016/j.cmet.2015.08.006

Pan, X.; Bradfield, C. A.; Hussain, M. M. Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis. Nat. Commun. 2016, 7 (1). DOI: 10.1038/ncomms130.

Rudic, R. D.; McNamara, P.; Curtis, A. M.; Boston, R. C.; Panda, S.; Hogenesch, J. B.; Fitzgerald, G. A. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol. 2004, 2 (11), 377. DOI: 10.1371/journal.pbio.0020377

Kim, C. W.; Yun, K. E.; Jung, H. S.; Chang, Y.; Choi, E. S.; Kwon, M. J.; Lee, E. H.; Woo, E. J.; Kim, N. H.; Shin, H.; Ryu, S. Sleep duration and quality in relation to non-alcoholic fatty liver disease in middle-aged workers and their spouses. J Hepatol. 2013, 59 (2), 351-357. DOI: 10.1016/j.jhep.2013.03.035

Lin, Y. M.; Chang, J. H.; Yeh, K. T.; Yang, M. Y.; Liu, T. C.; Lin, S. F.; Su, W. W.; Chang, J. G. Disturbance of circadian gene expression in hepatocellular carcinoma. Mol Carcinog. 2008, 47 (12), 925-933. DOI: 10.1002/mc.20446

Stevenson, N. R.; Ferrigni, F.; Parnicky, K.; Day, S.; Fierstein, J. S. Effect of changes in feeding schedule on the diurnal rhythms and daily activity levels of intestinal brush border enzymes and transport systems. Biochim Biophys Acta. 1975, 406 (1), 131-145. DOI: 10.1016/0005-2736(75)90048-6. PMID: 240440.

Qiu, J. M.; Roberts, S. A.; Potten, C. S. Cell migration in the small and large bowel shows a strong circadian rhythm. Epithelial Cell Biol. 1994, 3 (4), 137-148. PMID: 7550605.

Schernhammer, E. S.; Laden, F.; Speizer, F. E.; Willett, W. C.; Hunter, D. J.; Kawachi, I.; Fuchs, C. S.; Colditz, G. A. Night-shift work and risk of colorectal cancer in the nurses' health study. J Natl Cancer Inst. 2003, 95 (11), 825-8. DOI: 10.1093/jnci/95.11.825

Pérez, S.; Murias, L.; Fernández-Plaza, C.; Díaz, I.; González, C.; Otero, J.; Díaz, E. Evidence for clock genes circadian rhythms in human full-term placenta. Syst Biol Reprod Med. 2015, 61 (6), 360-366. DOI: 10.3109/19396368.2015.1069420

Rahman, S. A.; Grant, L. K.;Gooley, J. J.; Rajaratnam, S. M. W.; Czeisler, C. A.; Lockley, S. W. Endogenous Circadian Regulation of Female Reproductive Hormones. J Clin Endocrinol Metab. 2019, 104 (12), 6049-6059. DOI: 10.1210/jc.2019-00803

Alvarez, J. D.; Chen, D.; Storer, E.; Sehgal, A. Non-cyclic and developmental stage-specific expression of circadian clock proteins during murine spermatogenesis. Biol Reprod. 2003, 69 (1), 81-91. DOI: 10.1095/biolreprod.102.011833

Mahoney, M. M. Shift work, jet lag, and female reproduction. Int J Endocrinol. 2010, 2010. DOI: 10.1155/2010/813764

Endo, A.; Toshiaki, Watanabe. Effects of Non‐24‐Hour Days on Reproductive Efficacy and Embryonic Development in Mice. Gamete Research. 1989, 22 (4), 435–441. DOI:10.1002/mrd.1120220409

Bittman, E. L. Timing in the Testis. J Biol Rhythms. 2016, 31 (1), 12-36. DOI: 10.1177/0748730415618297

Peruquetti, R. L.; De Mateo, S.; Sassone-Corsi, P. Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells. PLoS One. 2012, 7 (8), DOI: 10.1371/journal.pone.0042695

Leproult, R.: Van Cauter, E. Effect of 1 week of sleep restriction on testosterone levels in young healthy men. JAMA. 2011, 305 (21), 2173-2174. DOI: 10.1001/jama.2011.710

Clinic, Cleveland. “Autonomic Nervous System: What It Is, Function & Disorders.” Cleveland Clinic, 2022, my.clevelandclinic.org/health/body/23273-autonomic-nervous-system. Accessed 21 Feb. 2024.

Riganello, F.; Prada, V.; Soddu, A.; di Perri, C.; Sannita, W. G. Circadian Rhythms and Measures of CNS/Autonomic Interaction. Int. J. Environ. Res. Public Health. 2019, 16, 2336. DOI:10.3390/ijerph16132336

‌Logan, R. W.; McClung, C. A . Rhythms of Life: Circadian Disruption and Brain Disorders across the Lifespan. Nature Reviews Neuroscience. 2018, 20 (1), 49–65. DOI: 10.1038/s41583-018-0088-y

Hall, A. L.; Franche, R. L.; Koehoorn, M. Examining Exposure Assessment in Shift Work Research: A Study on Depression Among Nurses. Ann Work Expo Health. 2018, 62 (2), 182-194. DOI:10.1093/annweh/wxx103

McNeely, E.; Mordukhovich, I.; Staffa, S.; Tideman, S.; Gale, S.; Coull, B. Cancer prevalence among flight attendants compared to the general population. Environ Health. 2018, 17 (1).DOI:10.1186/s12940-018-0396-8

Leso, V.; Fontana, L.; Caturano, A.; Vetrani, I.; Fedele, M.; Iavicoli, I. Impact of Shift Work and Long Working Hours on Worker Cognitive Functions: Current Evidence and Future Research Needs. Int J Environ Res Public Health. 2021, 18 (12), 6540. DOI:10.3390/ijerph18126540

Alhola, P.; Polo-Kantola, P. Sleep deprivation: Impact on cognitive performance. Neuropsychiatr Dis Treat. 2007, 3 (5), 553-567.

Rouch, I.; Wild, P.; Ansiau, D.; Marquié, J. C. Shiftwork experience, age and cognitive performance. Ergonomics. 2005, 48 (10) 1282-1293. DOI: 10.1080/00140130500241670. PMID: 16253945.

Kazemi, R.; Haidarimoghadam, R.; Motamedzadeh, M.; Golmohamadi, R.; Soltanian, A.; Zoghipaydar, M. R. Effects of Shift Work on Cognitive Performance, Sleep Quality, and Sleepiness among Petrochemical Control Room Operators. J Circadian Rhythms. 2016, 14 (1) DOI:10.5334/jcr.134. PMID: 27103934

Caruso, C. C.; Negative impacts of shiftwork and long work hours. Rehabil Nurs. 2014, 39 (1), 16-25. DOI:10.1002/rnj.107

Boyle, L. N.; Tippin, J.; Paul, A.; Rizzo, M.; Driver Performance in the Moments Surrounding a Microsleep. Transp Res Part F Traffic Psychol Behav. 2008, 11 (2), 126-136. DOI:10.1016/j.trf.2007.08.001

Babkoff, H.; Zukerman, G.; Fostick, L.; Ben-Artzi, E. Effect of the diurnal rhythm and 24 h of sleep deprivation on dichotic temporal order judgment. J Sleep Res. 2005, 4 (1), 7-15. DOI:10.1111/j.1365-2869.2004.00423.x

Hastings, M. H.; Reddy, A. B.; Maywood, E. S. A clockwork web: circadian timing in brain and periphery, in health and disease. Nat Rev Neurosci. 2003, 4 (8) 649-661. DOI: 10.1038/nrn1177. PMID: 12894240.

Dickmeis, T. Glucocorticoids and the circadian clock. J Endocrinol. 2009, 200 (1) 3-22. doi: 10.1677/JOE-08-0415.

Escobar, C.; Salgado-Delgado, R.; Gonzalez-Guerra, E.; Tapia, O. A.; Angeles-Castellanos, M.; Buijs, R. M. Circadian disruption leads to loss of homeostasis and disease. Sleep Disord. 2011, 2011:964510. doi: 10.1155/2011/964510.

Scheer, F. A.; Hilton, M. F.; Mantzoros, C. S.; Shea, S. A. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A. 2009, 106 (11) 4453-4458. DOI: 10.1073/pnas.0808180106.

Boivin, D. B.; JAMES, F. O. Light Treatment and Circadian Adaptation to Shift Work. Industrial Health. 2005, 43 (1) 34-48. DOI:0.2486/indhealth.43.34

Czeisler, C. A.; Allan, J. S.; Strogatz, S. H.; Ronda, J. M.; Sánchez, Ramiro.; Ríos, C. D.; Freitag, W. O.; Richardson, G. S.; Kronauer, R. E. Bright Light Resets the Human Circadian Pacemaker Independent of the Timing of the Sleep-Wake Cycle. Science. 1986, 233 (4764) 667-671. DOI:10.1126/science.3726555

Gumenyuk, V.; Howard, R.; Roth, T.; Korzyukov, O.; Drake, C. L. Sleep Loss, Circadian Mismatch, and Abnormalities in Reorienting of Attention in Night Workers with Shift Work Disorder. Sleep. 2014 37 (3) 545–556. DOI:10.5665/sleep.3494

Richardson, G. S.; Zee, P. C.; Wang-Weigand, S.; Rodriguez, L.; Peng, X. Circadian Phase-Shifting Effects of Repeated Ramelteon Administration in Healthy Adults. JCSM. 2008, 4 (5) 456-461. DOI: 10.5664/jcsm.27282

Damien, L.; Pierre, P.; Philippe, J.; Arnaud, M.; Dominique, C. Effects of a combination of napping and bright light pulses on shift workers' sleepiness at the wheel: a pilot study. J. Sleep. Res. 2009, 18 (4) 472-479. DOI:10.1111/j.1365-2869.2008.00676.x

Wright, K. P.; Bogan, R. K.; Wyatt, J. K. Shift work and the assessment and management of shift work disorder (SWD). Sleep Med. Rev. 2013, 17 (1) 41-54. DOI: 10.1016/j.smrv.2012.02.002.

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2024-06-29