F-box genes in Drosophila melanogaster: A Review
DOI:
https://doi.org/10.58445/rars.1213Keywords:
Drosophila, F-box genes, melanogasterAbstract
The archipelago gene (Ago) in Drosophila melanogaster prevents cell division. The gene Fbw7 (the mammalian equivalent of Ago), suppresses tumorigenesis, which is the process that can indicate whether cancer is present. Ago is essential in shaping the embryonic tracheal system in Drosophila post-mitosis. As current research reflects, Ago encodes for an SCF-type polyubiquitin ligase which inhibits tumor growth. However, research has found that it is probable that Ago has other protein targets. Researchers have discovered the Trachealess (Trh) protein, which Ago targets. However, there are mutations of Ago that elevate Trh levels in-vivo, making them ineffective in binding Trh in a Dysfusion positive cell. (Dysfusion is a gene found in Drosophila which controls the tracheal fusion event). It has been noted that Ago plays a role in tracheal morphogenesis, which is the process by which tracheal cells attach to one another. Despite their attachment in tracheal morphogenesis, these cells will continue to remain flexible, which will allow for rearrangement during different phases of development in Drosophila. Ago has noteworthy functions in cells that have undergone mitosis; such data can be utilized to highlight Ago’s role in disease and cell development. This review article intends to analyze the function of Ago in Dysfusion-positive cells. It will study various experiments on Drosophila that have allowed researchers to uncover the relationship between the Trh protein, Ago, and the Dysfusion protein.
References
Tolwinski N. S. (2017). Introduction: Drosophila-A Model System for Developmental Biology. Journal of developmental biology, 5(3), 9. https://doi.org/10.3390/jdb5030009
Papagiannouli, F., & M., B. (2013). Modeling Tumorigenesis in Drosophila: Current Advances and Future Perspectives. InTech. doi: 10.5772/55686
Facts. Facts - Fruit Flies | Max-Planck-Gesellschaft. (n.d.). https://www.mpg.de/10973625/why-do-scientists-investigate-fruit-flies#:~:text=Outwardly%2C%20fruit%20flies%20and%20humans,humans%20in%20a%20similar%20form.
Tolwinski N. S. (2017). Introduction: Drosophila-A Model System for Developmental Biology. Journal of developmental biology, 5(3), 9. https://doi.org/10.3390/jdb5030009
Medina, I., Calleja, M., & Morata, G. (2021). Tumorigenesis and cell competition in Drosophila in the absence of polyhomeotic function. Proceedings of the National Academy of Sciences of the United States of America, 118(45), e2110062118. https://doi.org/10.1073/pnas.2110062118
Herranz, H., & Cohen, S. M. (2017). Drosophila as a Model to Study the Link between Metabolism and Cancer. Journal of developmental biology, 5(4), 15. https://doi.org/10.3390/jdb5040015
Archipelago. (n.d.). https://www.sdbonline.org/sites/fly/sturtevant/archipelago1.htm
Welcker, M., & Clurman, B. E. (n.d.). FBW7 ubiquitin ligase: A tumour suppressor at the crossroads of cell division, growth and differentiation. Nature News. https://www.nature.com/articles/nrc2290
Chung, S., Chavez, C., & Andrew, D. J. (2011). Trachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis. Developmental biology, 360(1), 160–172. https://doi.org/10.1016/j.ydbio.2011.09.014
Jiang, L., & Crews, S. T. (2003). The Drosophila dysfusion basic helix-loop-helix (bHLH)-PAS gene controls tracheal fusion and levels of the trachealess bHLH-PAS protein. Molecular and cellular biology, 23(16), 5625–5637. https://doi.org/10.1128/MCB.23.16.5625-5637.2003
Mortimer, N. T., & Moberg, K. H. (2007). The Drosophila F-box protein Archipelago controls levels of the Trachealess transcription factor in the embryonic tracheal system. Developmental biology, 312(2), 560–571. https://doi.org/10.1016/j.ydbio.2007.10.002
Mishra, P., Singh, U., Pandey, C. M., Mishra, P., & Pandey, G. (2019). Application of student's t-test, analysis of variance, and covariance. Annals of cardiac anaesthesia, 22(4), 407–411. https://doi.org/10.4103/aca.ACA_94_19
Mortimer, N. T., & Moberg, K. H. (2007). The Drosophila F-box protein Archipelago controls levels of the Trachealess transcription factor in the embryonic tracheal system. Developmental biology, 312(2), 560–571. https://doi.org/10.1016/j.ydbio.2007.10.002
Mortimer, N. T., & Moberg, K. H. (2007). The Drosophila F-box protein Archipelago controls levels of the Trachealess transcription factor in the embryonic tracheal system. Developmental biology, 312(2), 560–571. https://doi.org/10.1016/j.ydbio.2007.10.002
Mortimer, N. T., & Moberg, K. H. (2009). Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia. Developmental biology, 329(2), 294–305. https://doi.org/10.1016/j.ydbio.2009.03.001
Dui, W., Lu, W., Ma, J., & Jiao, R. (2012). A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila. Journal of genetics and genomics = Yi chuan xue bao, 39(8), 397–413. https://doi.org/10.1016/j.jgg.2012.05.009
Dui, W., Lu, W., Ma, J., & Jiao, R. (2012). A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila. Journal of genetics and genomics = Yi chuan xue bao, 39(8), 397–413. https://doi.org/10.1016/j.jgg.2012.05.009
Mortimer, N. T., & Moberg, K. H. (2007). The Drosophila F-box protein Archipelago controls levels of the Trachealess transcription factor in the embryonic tracheal system. Developmental biology, 312(2), 560–571. https://doi.org/10.1016/j.ydbio.2007.10.002
NCI Dictionary of Genetics terms. National Cancer Institute. (n.d.). https://www.cancer.gov/publications/dictionaries/genetics-dictionary
Mortimer, N. T., & Moberg, K. H. (2007). The Drosophila F-box protein Archipelago controls levels of the Trachealess transcription factor in the embryonic tracheal system. Developmental biology, 312(2), 560–571. https://doi.org/10.1016/j.ydbio.2007.10.002
Mortimer, N. T., & Moberg, K. H. (2009). Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia. Developmental biology, 329(2), 294–305. https://doi.org/10.1016/j.ydbio.2009.03.001
Mortimer, N. T., & Moberg, K. H. (2009). Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia. Developmental biology, 329(2), 294–305. https://doi.org/10.1016/j.ydbio.2009.03.001
Dui, W., Lu, W., Ma, J., & Jiao, R. (2012). A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila. Journal of genetics and genomics = Yi chuan xue bao, 39(8), 397–413. https://doi.org/10.1016/j.jgg.2012.05.009
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