Preprint / Version 1

The impact of the oral microbiome on our mental health and decision making

##article.authors##

  • Jana Choe Student

DOI:

https://doi.org/10.58445/rars.107

Keywords:

microbiome, oral health, Mental health, publi

Abstract

Worldwide, cases of mental illnesses have been on the rise largely due to the COVID-19 pandemic. While multiple factors such as the environment, genetics, and childhood experiences are known to impact mental illness in humans, a large growing body of literature has recently focused on the microbes that inhabit our bodies. This article focuses on how the oral microbiome develops, how bacteria communicate with our environment and brains, and how these interactions impact our mental health and decision-making processes.

References

U.S. Department of Health and Human Services. (2022). Mental illness. National Institute

of Mental Health. https://www.nimh.nih.gov/health/statistics/mental-illness

Tsuang, M. T., Bar, J. L., Stone, W. S., & Faraone, S. V. (2004). Gene-environment

interactions in mental disorders. World psychiatry : official journal of the World Psychiatric

Association (WPA), 3(2), 73–83.

Wingfield, B., Lapsley, C., McDowell, A., Miliotis, G., McLafferty, M., O'Neill, S. M.,

Coleman, S., McGinnity, T. M., Bjourson, A. J., & Murray, E. K. (2021). Variations in the

oral microbiome are associated with depression in young adults. Scientific reports, 11(1),

https://doi.org/10.1038/s41598-021-94498-6

Altveş, S., Yildiz, H. K., & Vural, H. C. (2020). Interaction of the microbiota with the

human body in health and diseases. Bioscience of microbiota, food and health, 39(2),

–32. https://doi.org/10.12938/bmfh.19-023

Lamont, R. J., Koo, H., & Hajishengallis, G. (2018). The oral microbiota: Dynamic

communities and host interactions. Nature Reviews Microbiology, 16(12), 745-759.

https://doi.org/10.1038/s41579-018-0089-x

Sulyanto, R. M., Thompson, Z. A., Beall, C. J., Leys, E. J., & Griffen, A. L. (2019). The

predominant oral microbiota is acquired early in an organized pattern. Scientific Reports,

(1). https://doi.org/10.1038/ s41598-019-46923-0

Sedghi, L., Dimassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021). The oral

microbiome: Role of key organisms and complex networks in oral health and disease.

Periodontology 2000, 87(1), 107-131. https://doi.org/10.1111/prd.12393

Lif holgerson, P., Esberg, A., Sjödin, A., West, C. E., & Johansson, I. (2020). A

longitudinal study of the development of the saliva microbiome in infants 2 days to 5

years compared to the microbiome in adolescents. Scientific Reports, 10(1).

https://doi.org/10.1038/s41598-020-66658-7

Kaan, A. M., Kahharova, D., & Zaura, E. (2021). Acquisition and establishment of the oral

microbiota. Periodontology 2000, 86(1), 123-141. https://doi.org/10.1111/prd.12366

Burcham, Z. M., Garneau, N. L., Comstock, S. S., Tucker, R. M., Knight, R., & Metcalf, J.

L. (2020). Patterns of oral microbiota diversity in adults and children: A crowdsourced

population study. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-59016-0

Cho, Y.-D., Kim, K.-H., Lee, Y.-M., Ku, Y., & Seol, Y.-J. (2021). Oral microbiome and host

health: Review on current advances in genome-wide analysis. Applied Sciences, 11(9),

https://doi.org/10.3390/app11094050

Zaura, E., Keijser, B. J., Huse, S. M., & Crielaard, W. (2009). Defining the healthy "core

microbiome" of oral microbial communities. BMC Microbiology, 9(1), 259.

https://doi.org/10.1186/1471-2180-9-259

Martínez, M., Postolache, T. T., García-bueno, B., Leza, J. C., Figuero, E., Lowry, C. A., &

Malan-müller, S. (2022). The role of the oral microbiota related to periodontal diseases in

anxiety, mood and trauma- and stress-related disorders. Frontiers in Psychiatry, 12.

https://doi.org/10.3389/fpsyt.2021.814177

Hughes, D. T., & Sperandio, V. (2008). Inter-kingdom signalling: Communication between

bacteria and their hosts. Nature Reviews Microbiology, 6(2), 111-120.

https://doi.org/10.1038/nrmicro1836

Waters, C. M., & Bassler, B. L. (2005). Quorum sensing: Cell-to-Cell communication in

bacteria. Annual Review of Cell and Developmental Biology, 21(1), 319-346.

https://doi.org/10.1146/annurev.cellbio.21.012704.131001

Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I., & Tuohy, K. (2017).

Gut microbiota functions: Metabolism of nutrients and other food components. European

Journal of Nutrition, 57(1), 1-24. https://doi.org/10.1007/s00394-017-1445-8

Ahmed, E. (2020). Microbial endocrinology: Interaction of the microbial hormones with

the host. Biomedical Journal of Scientific & Technical Research, 24(2).

https://doi.org/10.26717/BJSTR.2020.24.004015

Wei, P., Keller, C., & Li, L. (2020). Neuropeptides in gut-brain axis and their influence on

host immunity and stress. Computational and Structural Biotechnology Journal, 18,

-851. https://doi.org/10.1016/j.csbj.2020.02.018

Ma, N., He, T., Johnston, L. J., & Ma, X. (2020). Host–microbiome interactions: The aryl

hydrocarbon receptor as a critical node in tryptophan metabolites to brain signaling. Gut

Microbes, 11(5), 1203-1219. https://doi.org/10.1080/19490976.2020.1758008

Bowland, G. B., & Weyrich, L. S. (2022). The oral-microbiome-brain axis and

neuropsychiatric disorders: An anthropological perspective. Frontiers in Psychiatry, 13.

https://doi.org/10.3389/fpsyt.2022.810008

Sharma, N., Bhatia, S., Singh sodhi, A., & Batra, N. (2018). Oral microbiome and health.

AIMS Microbiology, 4(1), 42-66. https://doi.org/10.3934/microbiol.2018.1.42

Duran-pinedo, A. E., Solbiati, J., & Frias-lopez, J. (2018). The effect of the stress

hormone cortisol on the metatranscriptome of the oral microbiome. Npj Biofilms and

Microbiomes, 4(1). https://doi.org/10.1038/s41522-018-0068-z

Roberts, A., Matthews, J. B., Socransky, S. S., Freestone, P. P. E., Williams, P. H., &

Chapple, I. L. C. (2002). Stress and the periodontal diseases: Effects of catecholamines

on the growth of periodontal bacteria in vitro. Oral Microbiology and Immunology, 17(5),

-303. https://doi.org/10.1034/j.1399-302x.2002.170506.x

Jentsch, H., März, D., & Krüger, M. (2013). The effects of stress hormones on growth of

selected periodontitis related bacteria. Anaerobe, 24, 49-54.

https://doi.org/10.1016/j.anaerobe.2013.09.001

World Health Organization, Mental Disorders, Published June 8th, 2022; Accessed

October 14th, 2022, who.int/news-room/fact-sheets/detail/mental-disorders

Maitre, Y., Micheneau, P., Delpierre, A., Mahalli, R., Guerin, M., Amador, G., & Denis, F.

(2020). Did the brain and oral microbiota talk to each other? A review of the literature.

Journal of Clinical Medicine, 9(12), 3876. https://doi.org/10.3390/jcm9123876

Bear, T., Dalziel, J., Coad, J., Roy, N., Butts, C., & Gopal, P. (2021). The

microbiome-gut-brain axis and resilience to developing anxiety or depression under

stress. Microorganisms, 9(4), 723. https://doi.org/10.3390/microorganisms9040723

Zhang, X., Zhang, X., Qiu, C., Shen, H., Zhang, H., He, Z., Song, Z., & Zhou, W. (2021).

The imbalance of th17/treg via stat3 activation modulates cognitive impairment in P.

gingivalis LPS‐induced periodontitis mice. Journal of Leukocyte Biology, 110(3), 511-524.

https://doi.org/10.1002/JLB.3MA0521-742RRR

Downloads

Posted

2023-01-03

Categories