Preprint / Version 1

The Role of HAP1 in the Progression of Huntington's Disease in Middle-aged Patients


  • Ayaan Arif American High School



Huntington's, Huntington's Disease, HAP1, HTT, CAG Repeats, Huntingtin, Neurodegenerative Diseases


This review paper wanted to look into the effect of HAP1 on the onset of Huntington’s Disease in middle-aged patients. Multiple research papers were reviewed, and found that a lack of HAP1 leads to an increased CAG repeat in certain areas of the brain. These CAG repeats in areas of the brain involved with motor functions cause those parts to deteriorate. When these parts of the brain deteriorate, nerve cells experience cell death as well, causing the nervous system to slowly shut down. Research points towards HAP1 monitoring and mediating CAG repeats, and the lack thereof leads to the phenomenon called Huntington’s Disease. Research towards other involved proteins such as HTT is necessary in the betterment of this paper, as HAP1 even being related towards the progression of Huntington’s is speculation.


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