Preprint / Version 1

Dysregulation of the Circadian Rhythm and its Effect on Alzheimer's Disease


  • Leo Wang Student



Circadian Rhythm, Alzheimer's Disease, protein buildup



Sleep, a fundamental physiological behavior, is primarily controlled by the circadian clock, an internal mechanism in the body that regulates the physiologically appropriate time of day for sleep. Dysregulation of circadian rhythms significantly contributes to pathogenesis in several neurodegenerative diseases, including Alzheimer’s disease, affecting millions worldwide. However, how this dysregulation of the circadian rhythm contributes to the onset of Alzheimer's disease is still unknown, and there is no effective treatment or cure for this neurodegenerative disease. In this paper, we comprehensively review the literature to understand how dysregulation of circadian rhythms may contribute to the onset of Alzheimer's disease. First, we investigated the relationship between circadian rhythms and sleep deprivation. The risk of developing Alzheimer's disease was higher in patients with sleep disturbances, which suggests that sleep disturbances and Alzheimer's disease might be linked. Preventative measures can be made to prevent the onset of Alzheimer’s disease. Second, we investigated the impact of abnormal protein buildup in Alzheimer's disease. Studying these proteins is the first step towards understanding the relationship between the dysregulation of the circadian rhythm and the onset of Alzheimer’s disease. Lastly, we investigated the dysregulation of circadian genes in Alzheimer's disease,  which plays a significant role in the onset of Alzheimer's disease. Sleep deprivation is a widespread problem in today's society, along with the prevalence of Alzheimer's disease. This work will help us further understand the mechanisms contributing to Alzheimer's disease and highlight circadian mechanisms as a possible target for investigation.



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