Preprint / Version 1

Optimizing Pharmaceutical Wastewater Treatment: A Comprehensive Review and Unique Experimental Insight

##article.authors##

  • Arnav Muthali BASIS Independent Silicon Valley

DOI:

https://doi.org/10.58445/rars.729

Keywords:

Pharmaceutical Wastewater Treatment, Advanced Oxidation Processes, conventional treatments

Abstract

The increased production and consumption of pharmaceuticals to combat evolving diseases, bacteria, and generally as a treatment (or an aid to) for unsolvable ailments (i.e. psychiatric treatments for Alzheimer's), results in higher concentrations of pharmaceuticals exposed to the environment both from production processes and human waste. Both in the production and in the disposal of pharmaceuticals does an increase of it as waste arises, seen at greatest effect at a local (to the production facility) level but can potentially become a global issue. The paper goes over conventional treatments for pharmaceutical wastewater. These treatments are classed under Advanced Oxidation Processes, Bio-activated methods, and treatments that involve separation methods. These treatments are then evaluated for their qualities, good and bad, when dealing with pharmaceutical wastewater, and then are either chosen or discarded for the final two sections. The final two sections then create an experimental treatment solution post-evaluation of wastewater treatment solutions that are considered stable and beneficial, and then that will be evaluated, with the limitations being discussed and alternative perspectives given.

References

Adeleye, Adeyemi S., et al. “Abundance, Fate, and Effects of Pharmaceuticals and Personal Care Products in Aquatic Environments.” Journal of Hazardous Materials, vol. 424, Feb. 2022, p. 127284. DOI.org (Crossref), https://doi.org/10.1016/j.jhazmat.2021.127284.

Andreozzi, Roberto, et al. “Antibiotic Removal from Wastewaters: The Ozonation of Amoxicillin.” Journal of Hazardous Materials, vol. 122, no. 3, July 2005, pp. 243–50. DOI.org (Crossref), https://doi.org/10.1016/j.jhazmat.2005.03.004.

Ankley, Gerald T., et al. “Repeating History: Pharmaceuticals in the Environment.” Environmental Science & Technology, vol. 41, no. 24, Dec. 2007, pp. 8211–17. DOI.org (Crossref), https://doi.org/10.1021/es072658j.

Araña, J., et al. “TiO2-Photocatalysis as a Tertiary Treatment of Naturally Treated Wastewater.” Catalysis Today, vol. 76, no. 2, Nov. 2002, pp. 279–89. ScienceDirect, https://doi.org/10.1016/S0920-5861(02)00226-2.

Aydin, Sevcan, et al. “Development of Antibiotic Resistance Genes in Microbial Communities during Long-Term Operation of Anaerobic Reactors in the Treatment of Pharmaceutical Wastewater.” Water Research, vol. 83, Oct. 2015, pp. 337–44. DOI.org (Crossref), https://doi.org/10.1016/j.watres.2015.07.007.

Barnes, Kimberlee K., et al. “A National Reconnaissance of Pharmaceuticals and Other Organic Wastewater Contaminants in the United States — I) Groundwater.” Science of The Total Environment, vol. 402, no. 2–3, Sept. 2008, pp. 192–200. DOI.org (Crossref), https://doi.org/10.1016/j.scitotenv.2008.04.028.

Benotti, Mark J., et al. “Evaluation of a Photocatalytic Reactor Membrane Pilot System for the Removal of Pharmaceuticals and Endocrine Disrupting Compounds from Water.” Water Research, vol. 43, no. 6, Apr. 2009, pp. 1513–22. ScienceDirect, https://doi.org/10.1016/j.watres.2008.12.049.

Bogush, A. A., et al. “Removal of Arsenic, Nitrate, Persistent Organic Pollutants and Pathogenic Microbes from Water Using Redox-Reactive Minerals.” Redox-Reactive Minerals: Properties, Reactions and Applications in Clean Technologies, by K.A. Hudson-Edwards, edited by I.A.M. Ahmed, 1st ed., Mineralogical Society of Great Britain & Ireland, 2007, pp. 405–42. DOI.org (Crossref), https://doi.org/10.1180/EMU-notes.17.12.

---. “Removal of Arsenic, Nitrate, Persistent Organic Pollutants and Pathogenic Microbes from Water Using Redox-Reactive Minerals.” Redox-Reactive Minerals: Properties, Reactions and Applications in Clean Technologies, by K.A. Hudson-Edwards, edited by I.A.M. Ahmed, 1st ed., Mineralogical Society of Great Britain & Ireland, 2007, pp. 405–42. DOI.org (Crossref), https://doi.org/10.1180/EMU-notes.17.12.

Chopra, Sunil, and Dharmender Kumar. “Pharmaceuticals and Personal Care Products (PPCPs) as Emerging Environmental Pollutants: Toxicity and Risk Assessment.” Advances in Animal Biotechnology and Its Applications, edited by Suresh Kumar Gahlawat et al., Springer, 2018, pp. 337–53. Springer Link, https://doi.org/10.1007/978-981-10-4702-2_19.

Clarizia, L., et al. “Homogeneous Photo-Fenton Processes at near Neutral pH: A Review.” Applied Catalysis B: Environmental, vol. 209, July 2017, pp. 358–71. DOI.org (Crossref), https://doi.org/10.1016/j.apcatb.2017.03.011.

Cokgor, Emine Ubay, et al. “Biological Treatability of Raw and Ozonated Penicillin Formulation Effluent.” Journal of Hazardous Materials, vol. 116, no. 1, Dec. 2004, pp. 159–66. ScienceDirect, https://doi.org/10.1016/j.jhazmat.2004.08.011.

Corcoran, Jenna, et al. “Pharmaceuticals in the Aquatic Environment: A Critical Review of the Evidence for Health Effects in Fish.” Critical Reviews in Toxicology, vol. 40, no. 4, Apr. 2010, pp. 287–304. DOI.org (Crossref), https://doi.org/10.3109/10408440903373590.

Deegan, A. M., et al. “Treatment Options for Wastewater Effluents from Pharmaceutical Companies.” International Journal of Environmental Science & Technology, vol. 8, no. 3, June 2011, pp. 649–66. DOI.org (Crossref), https://doi.org/10.1007/BF03326250.

Feng, Xianghua, et al. “Degradation of Estrone in Aqueous Solution by Photo-Fenton System.” Science of The Total Environment, vol. 345, no. 1, June 2005, pp. 229–37. ScienceDirect, https://doi.org/10.1016/j.scitotenv.2004.11.008.

Fent, K., et al. “Ecotoxicology of Human Pharmaceuticals.” Aquatic Toxicology, vol. 76, no. 2, Feb. 2006, pp. 122–59. DOI.org (Crossref), https://doi.org/10.1016/j.aquatox.2005.09.009.

Fick, Jerker, et al. “Contamination of Surface, Ground, and Drinking Water from Pharmaceutical Production.” Environmental Toxicology and Chemistry, vol. 28, no. 12, Dec. 2009, pp. 2522–27. DOI.org (Crossref), https://doi.org/10.1897/09-073.1.

Ganiyu, Soliu O., Eric D. Van Hullebusch, et al. “Coupling of Membrane Filtration and Advanced Oxidation Processes for Removal of Pharmaceutical Residues: A Critical Review.” Separation and Purification Technology, vol. 156, Dec. 2015, pp. 891–914. DOI.org (Crossref), https://doi.org/10.1016/j.seppur.2015.09.059.

Ganiyu, Soliu O., Eric D. van Hullebusch, et al. “Coupling of Membrane Filtration and Advanced Oxidation Processes for Removal of Pharmaceutical Residues: A Critical Review.” Separation and Purification Technology, vol. 156, Dec. 2015, pp. 891–914. ScienceDirect, https://doi.org/10.1016/j.seppur.2015.09.059.

Gerrity, Daniel, et al. “Pharmaceuticals and Endocrine Disrupting Compounds in Drinking Water.” Biophysico-Chemical Processes of Anthropogenic Organic Compounds in Environmental Systems, Jan. 2011, pp. 233–50, https://doi.org/10.1002/9780470944479.ch10.

Giri, Ardhendu Sekhar, and Animes Kumar Golder. “Fenton, Photo-Fenton, H 2 O 2 Photolysis, and TiO 2 Photocatalysis for Dipyrone Oxidation: Drug Removal, Mineralization, Biodegradability, and Degradation Mechanism.” Industrial & Engineering Chemistry Research, vol. 53, no. 4, Jan. 2014, pp. 1351–58. DOI.org (Crossref), https://doi.org/10.1021/ie402279q.

Guo, Y., et al. “A Review on Advanced Treatment of Pharmaceutical Wastewater.” IOP Conference Series: Earth and Environmental Science, vol. 63, May 2017, p. 012025. DOI.org (Crossref), https://doi.org/10.1088/1755-1315/63/1/012025.

Heberer, Thomas. “Occurrence, Fate, and Removal of Pharmaceutical Residues in the Aquatic Environment: A Review of Recent Research Data.” Toxicology Letters, vol. 131, no. 1–2, May 2002, pp. 5–17. DOI.org (Crossref), https://doi.org/10.1016/S0378-4274(02)00041-3.

Jing, Zhaoqian, and Shiwei Cao. “Combined Application of UV Photolysis and Ozonation with Biological Aerating Filter in Tertiary Wastewater Treatment.” International Journal of Photoenergy, vol. 2012, 2012, pp. 1–6. DOI.org (Crossref), https://doi.org/10.1155/2012/140605.

Kavitha, V., and K. Palanivelu. “The Role of Ferrous Ion in Fenton and Photo-Fenton Processes for the Degradation of Phenol.” Chemosphere, vol. 55, no. 9, June 2004, pp. 1235–43. ScienceDirect, https://doi.org/10.1016/j.chemosphere.2003.12.022.

Kremer, Mordechai L. “Mechanism of the Fenton Reaction. Evidence for a New Intermediate.” Physical Chemistry Chemical Physics, vol. 1, no. 15, 1999, pp. 3595–605. DOI.org (Crossref), https://doi.org/10.1039/a903915e.

Krishnan, Radhakrishnan Yedhu, et al. “Removal of Emerging Micropollutants Originating from Pharmaceuticals and Personal Care Products (PPCPs) in Water and Wastewater by Advanced Oxidation Processes: A Review.” Environmental Technology & Innovation, vol. 23, Aug. 2021, p. 101757. ScienceDirect, https://doi.org/10.1016/j.eti.2021.101757.

LaPara, Timothy M., et al. “Stability of the Bacterial Communities Supported by a Seven-Stage Biological Process Treating Pharmaceutical Wastewater as Revealed by PCR-DGGE.” Water Research, vol. 36, no. 3, Feb. 2002, pp. 638–46. ScienceDirect, https://doi.org/10.1016/S0043-1354(01)00277-9.

Larsen, Tove A., et al. “How to Avoid Pharmaceuticals in the Aquatic Environment.” Journal of Biotechnology, vol. 113, no. 1–3, Sept. 2004, pp. 295–304. DOI.org (Crossref), https://doi.org/10.1016/j.jbiotec.2004.03.033.

Legrini, O., et al. “Photochemical Processes for Water Treatment.” ACS Publications, American Chemical Society, 1 May 2002, https://doi.org/10.1021/cr00018a003. world.

Leónidas A. Pérez-Estrada, †, et al. “Photo-Fenton Degradation of Diclofenac: Identification of Main Intermediates and Degradation Pathway.” ACS Publications, American Chemical Society, 21 Sept. 2005, https://doi.org/10.1021/es050794n. world.

Lin, Yen-Hui. “Molecular Weight Distribution of Organic Matter by Ozonation and Biofiltration.” Water Science and Technology : A Journal of the International Association on Water Pollution Research, vol. 66, Oct. 2012, pp. 2604–12. ResearchGate, https://doi.org/10.2166/wst.2012.484.

Loganathan, Paripurnanda, et al. “Submerged Membrane/Adsorption Hybrid Process in Water Reclamation and Concentrate Management—a Mini Review.” Environmental Science and Pollution Research, vol. 30, no. 15, Sept. 2022, pp. 42738–52. DOI.org (Crossref), https://doi.org/10.1007/s11356-022-23229-9.

Maartens, A., et al. “An Enzymatic Approach to the Cleaning of Ultrafiltration Membranes Fouled in Abattoir Effluent.” Journal of Membrane Science, vol. 119, no. 1, Oct. 1996, pp. 9–16. DOI.org (Crossref), https://doi.org/10.1016/0376-7388(96)00015-4.

Madukasi, E. I., et al. “Potentials of Phototrophic Bacteria in Treating Pharmaceutical Wastewater.” International Journal of Environmental Science & Technology, vol. 7, no. 1, Dec. 2010, pp. 165–74. DOI.org (Crossref), https://doi.org/10.1007/BF03326128.

Maskooki, Abdolmajid, et al. “Cleaning of Spiralwound Ultrafiltration Membranes Using Ultrasound and Alkaline Solution of EDTA.” Desalination, vol. 264, no. 1–2, Dec. 2010, pp. 63–69. DOI.org (Crossref), https://doi.org/10.1016/j.desal.2010.07.005.

Miège, C., et al. “Fate of Pharmaceuticals and Personal Care Products in Wastewater Treatment Plants – Conception of a Database and First Results.” Environmental Pollution, vol. 157, no. 5, May 2009, pp. 1721–26. DOI.org (Crossref), https://doi.org/10.1016/j.envpol.2008.11.045.

Muñoz, Ivan, et al. “Life Cycle Assessment of a Coupled Solar Photocatalytic–Biological Process for Wastewater Treatment.” Water Research, vol. 40, no. 19, Nov. 2006, pp. 3533–40. DOI.org (Crossref), https://doi.org/10.1016/j.watres.2006.08.001.

Nakada, Norihide, et al. “Removal of Selected Pharmaceuticals and Personal Care Products (PPCPs) and Endocrine-Disrupting Chemicals (EDCs) during Sand Filtration and Ozonation at a Municipal Sewage Treatment Plant.” Water Research, vol. 41, no. 19, Nov. 2007, pp. 4373–82. ScienceDirect, https://doi.org/10.1016/j.watres.2007.06.038.

Obotey Ezugbe, Elorm, and Sudesh Rathilal. “Membrane Technologies in Wastewater Treatment: A Review.” Membranes, vol. 10, no. 5, Apr. 2020, p. 89. DOI.org (Crossref), https://doi.org/10.3390/membranes10050089.

Oz, Nilgun Ayman, et al. “Effect of Wastewater Composition on Methanogenic Activity in an Anaerobic Reactor.” Journal of Environmental Science and Health, Part A, vol. 39, no. 11–12, Dec. 2004, pp. 2941–53. Taylor and Francis+NEJM, https://doi.org/10.1081/LESA-200034284.

Pandey, Aditi, and Ravi Singh. “Industrial Waste Water Treatment by Membrane Bioreactor System.” Elixir Chemical Engineering, vol. 70, Apr. 2014, pp. 23772–77.

Popović, Svetlana, et al. “Application of an Ultrasound Field in Chemical Cleaning of Ceramic Tubular Membrane Fouled with Whey Proteins.” Journal of Food Engineering, vol. 101, no. 3, Dec. 2010, pp. 296–302. DOI.org (Crossref), https://doi.org/10.1016/j.jfoodeng.2010.07.012.

Renita, A. Annam, et al. “A Review on Analytical Methods and Treatment Techniques of Pharmaceutical Wastewater.” DESALINATION AND WATER TREATMENT, vol. 87, 2017, pp. 160–78. DOI.org (Crossref), https://doi.org/10.5004/dwt.2017.21311.

Rizzo, L., et al. “Urban Wastewater Treatment Plants as Hotspots for Antibiotic Resistant Bacteria and Genes Spread into the Environment: A Review.” Science of The Total Environment, vol. 447, Mar. 2013, pp. 345–60. DOI.org (Crossref), https://doi.org/10.1016/j.scitotenv.2013.01.032.

Rosman, Nurafiqah, et al. “Hybrid Membrane Filtration-Advanced Oxidation Processes for Removal of Pharmaceutical Residue.” Journal of Colloid and Interface Science, vol. 532, Dec. 2018, pp. 236–60. DOI.org (Crossref), https://doi.org/10.1016/j.jcis.2018.07.118.

Ryan, Christopher C., et al. “Direct and Indirect Photolysis of Sulfamethoxazole and Trimethoprim in Wastewater Treatment Plant Effluent.” Water Research, vol. 45, no. 3, Jan. 2011, pp. 1280–86. DOI.org (Crossref), https://doi.org/10.1016/j.watres.2010.10.005.

Shemer, Hilla, et al. “Degradation of the Pharmaceutical Metronidazole via UV, Fenton and Photo-Fenton Processes.” Chemosphere, vol. 63, no. 2, Apr. 2006, pp. 269–76. ScienceDirect, https://doi.org/10.1016/j.chemosphere.2005.07.029.

Singh, Rajindar. “Chapter 3 - Hybrid Membrane Systems – Applications and Case Studies.” Membrane Technology and Engineering for Water Purification (Second Edition), edited by Rajindar Singh, Butterworth-Heinemann, 2015, pp. 179–281. ScienceDirect, https://doi.org/10.1016/B978-0-444-63362-0.00003-3.

Sreekanth, D., et al. “Thermophilic Treatment of Bulk Drug Pharmaceutical Industrial Wastewaters by Using Hybrid up Flow Anaerobic Sludge Blanket Reactor.” Bioresource Technology, vol. 100, no. 9, May 2009, pp. 2534–39. DOI.org (Crossref), https://doi.org/10.1016/j.biortech.2008.11.028.

Stapleton, D. R., et al. “Photolytic Destruction of Halogenated Pyridines in Wastewaters.” Process Safety and Environmental Protection, vol. 84, no. 4, July 2006, pp. 313–16. ScienceDirect, https://doi.org/10.1205/psep.05164.

Stumm-Zollinger, Elisabeth, and Gordon M. Fair. “Biodegradation of Steroid Hormones.” Journal (Water Pollution Control Federation), vol. 37, no. 11, 1965, pp. 1506–10.

Suman Raj, D. Samuel, and Y. Anjaneyulu. “Evaluation of Biokinetic Parameters for Pharmaceutical Wastewaters Using Aerobic Oxidation Integrated with Chemical Treatment.” Process Biochemistry, vol. 40, no. 1, Jan. 2005, pp. 165–75. DOI.org (Crossref), https://doi.org/10.1016/j.procbio.2003.11.056.

Ternes, Thomas A., et al. “Ozonation: A Tool for Removal of Pharmaceuticals, Contrast Media and Musk Fragrances from Wastewater?” Water Research, vol. 37, no. 8, Apr. 2003, pp. 1976–82. ScienceDirect, https://doi.org/10.1016/S0043-1354(02)00570-5.

Wang, Jian Long, and Le Jin Xu. “Advanced Oxidation Processes for Wastewater Treatment: Formation of Hydroxyl Radical and Application.” Critical Reviews in Environmental Science and Technology, vol. 42, no. 3, Feb. 2012, pp. 251–325. DOI.org (Crossref), https://doi.org/10.1080/10643389.2010.507698.

Yu, Zirui, et al. Adsorption of Selected Pharmaceuticals and Endocrine Disrupting Substances by GAC at Low Concentration Levels.

Downloads

Posted

2023-11-18