Smoking and Oxidative Stress: A New Lens to Consider Alzheimer’s Disease
DOI:
https://doi.org/10.58445/rars.681Keywords:
smoking, oxidative stress, Alzheimer's DiseaseAbstract
Smoking is a prevalent habit across the world, with about 2 billion individuals using tobacco products, typically in the form of smoking cigarettes. In the United States alone, there are an estimated 44 million active smokers. Smoking is recognized as a tremendous risk factor for various health conditions, such as CVD, COPD, stroke, and cancer, and emerging evidence demonstrates that it can also have detrimental effects on neurobiological aspects of the brain and cause neurocognitive abnormalities. Recent studies have shown that these smoking-related neural abnormalities can potentially serve as risk factors for Alzheimer’s disease. Smoking itself can lead to an increased risk of Alzheimer’s Disease and the progression of Alzheimer's pathology, and the extent of its effect can vary due to age and individual characteristics. This review explores the different neurobiological abnormalities that are caused by smoking, and its contribution to the pathogenesis of Alzheimer’s Disease.
References
A. Armstrong, R. (2019). Risk factors for Alzheimer’s disease. Folia Neuropathologica, 57(2), 87-105. https://doi.org/10.5114/fn.2019.85929
Arcavi, L., & Benowitz, N. L. (2004). Cigarette Smoking and Infection. Archives of Internal Medicine, 164(20), 2206–2216.
Bai, R., Xiang-Yang Ye, J. G., Xie, Y., & Xie, T. (2022, April 5). Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease. Ageing Research Reviews. https://www.sciencedirect.com/science/article/abs/pii/S1568163722000617?via%3Dihub
Barrera, G., Pizzimenti, S., Daga, M., Dianzani, C., Arcaro, A., Cetrangolo, G. P., Giordano, G., Cucci, M. A., Graf, M., & Gentile, F. (2018, July 30). Lipid peroxidation-derived aldehydes, 4-hydroxynonenal and Malondialdehyde in aging-related disorders. Antioxidants (Basel, Switzerland). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115986/
Benowitz, N. L. (2009). Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics. Annual Review of Pharmacology and Toxicology, 49, 57–71.
Blennow, K., Dubois, B., Fagan, A. M., Lewczuk, P., de Leon, M. J., & Hampel, H. (2015). Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease. Alzheimer's & Dementia, 11(1), 58-69.
Blinkouskaya, Y., Cacoilo, A., Gollamudi, T., Jalalian, S., & Weickenmeier, J. (2021, October 1). Brain aging mechanisms with mechanical manifestations. Mechanisms of Ageing and Development. https://www.sciencedirect.com/science/article/pii/S0047637421001470?via%3Dihub
Centers for Disease Control and Prevention. (2023, May 4). Current cigarette smoking among adults in the United States. Centers for Disease Control and Prevention. https://www.cdc.gov/tobacco/data_statistics/fact_sheets/adult_data/cig_smoking/index.htm#:~:text=In%202021%2C%20nearly%2012%20of,with%20a%20smoking%2Drelated%20disease.
Centers for Disease Control and Prevention (CDC). (2021a). Smoking & Tobacco Use: Fast Facts. https://www.cdc.gov/tobacco/data_statistics/fact_sheets/fast_facts/index.htm
Centers for Disease Control and Prevention (CDC). (2021b). Current Cigarette Smoking Among Adults in the United States. https://www.cdc.gov/tobacco/data_statistics/fact_sheets/adult_data/cig_smoking/index.htm
Chen, Z., & Zhong, C. (2014, March 24). Oxidative stress in Alzheimer’s disease - Neuroscience Bulletin. SpringerLink. https://link.springer.com/article/10.1007/s12264-013-1423-y
Chiolero, A., Faeh, D., Paccaud, F., & Cornuz, J. (2008). Consequences of smoking for body weight, body fat distribution, and insulin resistance. American Journal of Clinical Nutrition, 87(4), 801–809.
Cornelius, M. E., Loretan, C. G., Jamal, A., Davis Lynn, B. C., Mayer, M., Alcantara, I. C., & Neff, L. (2023). Tobacco Product Use Among Adults - United States, 2021. MMWR. Morbidity and mortality weekly report, 72(18), 475–483. https://doi.org/10.15585/mmwr.mm7218a1
Crimmins EM. Lifespan and Healthspan: Past, Present, and Promise. Gerontologist. 2015 Dec;55(6):901-11. doi: 10.1093/geront/gnv130. Epub 2015 Nov 10. PMID: 26561272; PMCID: PMC4861644.
De-Paula, V. J., Radanovic, M., Diniz, B. S., & Forlenza, O. V. (2019). Neurobiology of behavior disturbances in Alzheimer's disease: current status and future perspectives. Alzheimer's & Dementia, 15
Durazzo, T., Mattsson, N., & Weiner, M. (2014, June 10). Smoking and increased Alzheimer’s disease risk: A review of potential mechanisms. Alzheimer’s & Dementia. https://www.sciencedirect.com/science/article/pii/S155252601400137X?via%3Dihub
Durazzo, T. C., Meyerhoff, D. J., & Nixon, S. J. (2014). Chronic cigarette smoking: implications for neurocognition and brain neurobiology. The International Journal of Environmental Research and Public Health, 11(11), 11605–11626.
Eratne, D., Loi, S. M., Farrand, S., Kelso, W., Velakoulis, D., & Looi, J. C. (2018). Alzheimer’s disease: clinical update on epidemiology, pathophysiology and diagnosis. Australasian Psychiatry, 26(4), 347–357. doi:10.1177/1039856218762308
Ezzati, M., Lopez, A. D., & Rodgers, A. A. (2003). Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors. World Health Organization.
Grossman, M., Farmer, J., Leight, S., Work, M., Moore, P., Van Deerlin, V., ... & Trojanowski, J. Q. (2017). Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's disease. Annals of Neurology, 24(3), 407-411.
Imbimbo, B. P., Lombard, J., & Pomara, N. (2005). Pathophysiology of Alzheimer’s Disease. Neuroimaging Clinics of North America, 15(4), 727–753. doi:10.1016/j.nic.2005.09.009
Ionescu-Tucker, A., & Cotman, C. (2021, July). Emerging roles of oxidative stress in Brain aging and alzheimer’s disease. Neurobiology of aging. https://pubmed.ncbi.nlm.nih.gov/34416493/
Jamal, A., Phillips, E., Gentzke, A. S., Homa, D. M., Babb, S. D., King, B. A., & Neff, L. J. (2018). Current Cigarette Smoking Among Adults — United States, 2016. MMWR. Morbidity and Mortality Weekly Report, 67(2), 53–59.
Jha, P., Ramasundarahettige, C., Landsman, V., Rostron, B., Thun, M., Anderson, R. N., … Peto, R. (2014). 21st-Century Hazards of Smoking and Benefits of Cessation in the United States. New England Journal of Medicine, 370(4), 341–350.
Kuhn, S., Gallinat, J., & Musso, F. (2010). Smoking influences grey matter volume in the mesolimbic brain. European Archives of Psychiatry and Clinical Neuroscience, 260(2), 343–347.
Mishra, S., & Chaudhry, A. (2020). Impact of Oxidative Stress on Alzheimer's Disease Pathogenesis: Role of Metal Toxicity. Alzheimer's Disease: Pathogenesis, Cellular Mechanisms, and Therapeutics, 151–175.
Onojighofia Tobore, T. (2019). On the Etiopathogenesis and Pathophysiology of Alzheimer’s Disease: A Comprehensive Theoretical Review. Journal of Alzheimer’s Disease, 1–21. doi:10.3233/jad-181052
Ozguner, F., Koyu, A., & Cesur, G. (2005). Active smoking causes oxidative stress and decreases blood melatonin levels. Toxicology and industrial health, 21(1-2), 21–26. https://doi.org/10.1191/0748233705th211oa
Patra, J., Bhatia, M., Suraweera, W., Morris, S. K., Patra, C., Gupta, P. C., & Jha, P. (2018). Exposure to second-hand smoke and the risk of tuberculosis in children and adults: a systematic review and meta-analysis of 18 observational studies. PLoS Medicine, 15(6), e1002597.
Petersen, R. C., Caracciolo, B., Brayne, C., Gauthier, S., Jelic, V., & Fratiglioni, L. (2014). Mild cognitive impairment: a concept in evolution. Journal of Internal Medicine, 275(3), 214-228.
Picciotto, M. R., & Kenny, P. J. (2013). Molecular Mechanisms Underlying Behaviors Related to Nicotine Addiction. Cold Spring Harbor Perspectives in Medicine, 3(1), a012112.
Pike, C. (2016, November 7). Sex and the development of Alzheimer's Disease - Wiley Online Library. Wiley Online Library. https://onlinelibrary.wiley.com/doi/pdf/10.1002/jnr.23827
Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, Mucke L. Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10914-9. doi: 10.1073/pnas.95.18.10914. PMID: 9724804; PMCID: PMC27995.
Salmon, T. B., Evert, B. A., Song, B., & Doetsch, P. W. (2004). Biological consequences of oxidative stress-induced DNA damage in Saccharomyces cerevisiae. Nucleic acids research, 32(12), 3712–3723. https://doi.org/10.1093/nar/gkh696
Schoenborn, C. A., & Gindi, R. M. (2019). Electronic Cigarette Use Among Adults: United States, 2014–2018. NCHS Data Brief, (365), 1–8.
Shields, H. J., Traa, A., & Van Raamsdonk, J. M. (2021, February 11). Beneficial and detrimental effects of reactive oxygen species on lifespan: A comprehensive review of comparative and experimental studies. Frontiers in cell and developmental biology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905231/#:~:text=Reactive%20oxygen%20species%20(ROS)%20can,of%20guanine%20to%208%2Doxoguanine.
Sies, H. (2015, January 2). Oxidative stress: a concept in redox biology and medicine. Redox Biology. https://www.sciencedirect.com/science/article/pii/S2213231715000038?via%3Dihub
Shin J. H. (2022). Dementia Epidemiology Fact Sheet 2022. Annals of rehabilitation medicine, 46(2), 53–59. https://doi.org/10.5535/arm.22027
Srivastava, S., Ahmad, R., & Share, S. K. (2021, February 23). Alzheimer’s disease and its treatment by different approaches: A review. European Journal of Medicinal Chemistry. https://www.sciencedirect.com/science/article/abs/pii/S0223523421001690?via%3Dihub
Thun, M. J., Carter, B. D., Feskanich, D., Freedman, N. D., Prentice, R., Lopez, A. D., Hartge, P., Gapstur, S. M. (2013). 50-Year Trends in Smoking-Related Mortality in the United States. New England Journal of Medicine, 368(4), 351–364.
United States Department of Health and Human Services. (2020). Smoking
U.S. Department of Health and Human Services. (2014). The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. https://www.ncbi.nlm.nih.gov/books/NBK179276/
Vogel, J. W., Varga, D., Schiff, N. D., Gomperts, S. N., & Fowler, K. S. (2020). Multimodal signatures of brain structure and function preceding and following advanced age. Brain Imaging and Behavior, 14(3), 767-779.
Volkow, N. D., Wang, G. J., Fowler, J. S., Logan, J., Gatley, S. J., Hitzemann, R., ... & Pappas, N. (2010). Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcoholism: Clinical and Experimental Research, 24(11), 1575-1582.
Wills, T. A., & Sargent, J. D. (2020). The Unfinished Business of Youth Smoking Prevention. JAMA Pediatrics, 174(2), 115-116.
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