The Neuroprotective Role of Estrogen Across Reproductive Stages and Its Implications for Alzheimer’s Disease in Women
DOI:
https://doi.org/10.58445/rars.4107Keywords:
Alzheimer’s Disease, Estrogen, Neuroprotective Role, Reproductive StagesAbstract
Hormonal changes across lifespan (stages) in women could be contributing, where estrogen and prog levels fluctuate. Estrogen has been shown to support memory and brain function, so in these stages where estrogen levels decline, it could contribute to AD symptoms, including decline in memory and cognitive function. One key area where estrogen is neuroprotective is through support of memory, communication between nerve cells synapses, and glucose metabolism as well as being an anti-inflammatory agent in the brain. As estrogen levels decline during menopause, regions in the brain like the hippocampus could be more prone to the various symptoms resulting from AD like memory loss, brain fog, and development of amyloid plaques and tau tangles in the brain. Hormone Replacement Therapy (HRT/ERT) has been studied for its role to potentially prevent AD, but results from research have been inconsistent with no proper conclusion.
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