Music and Epilepsy
A Literature Review
DOI:
https://doi.org/10.58445/rars.3279Keywords:
epilepsy, music, seizures, epileptiform discharge, musicogenic epilepsy, music therapy, sound therapyAbstract
Epilepsy has been increasingly studied in relation to auditory stimuli. Research has demonstrated the health-promoting and seizure-inducing influence of music on the epileptic brain. The objective of this literature review is to investigate the potential therapeutic and adverse outcomes of music in people with epilepsy. Understanding how music and sound impact symptoms and rehabilitation in epilepsy patients may support the development of effective therapeutic and rehabilitative strategies for epilepsy. This review examines empirical studies, meta-analyses, and literature reviews to identify circumstances under which auditory stimuli may alleviate or trigger symptoms. Studies were reviewed for their designs, participant characteristics, auditory stimulus types, and outcome measures involving seizure frequency and epileptiform activity. Evidence indicates that certain musical stimuli, including specific compositions, and clinical interventions involving music training or exposure may reduce seizures and epileptiform discharges and contribute to psychosocial wellbeing. Conversely, music has also been reported to trigger seizures. The findings suggest a complex, context-dependent association between musical stimuli and restorative or detrimental outcomes on individuals with epilepsy. The underlying neural mechanisms for the therapeutic and adverse effects of music on epilepsy patients remain poorly understood. Further research is necessary to determine optimal conditions for safe, effective auditory-based treatment interventions and diagnostic procedures for epilepsy.
References
Abramaviciute, Z., and V. Aleksiene. “Music Therapy in the Psychosocial Rehabilitation of People with Epilepsy.” SHS Web of Conferences, vol. 2, 2012, p. 00001, https://doi.org/10.1051/SHSCONF/20120200001.
Bratu, Ionut Flavius, et al. “Musicogenic Seizures in Temporal Lobe Epilepsy: Case Reports Based on Ictal Source Localization Analysis.” Frontiers in Neurology, vol. 14, 2023, https://doi.org/10.3389/FNEUR.2023.1072075.
Francisco, Leonor, and Marta Carvalho. “Musicogenic Epilepsy in Adults: Epileptogenesis and Management Update.” Sinapse, vol. 21, no. 2, Apr. 2021, pp. 85–92, https://doi.org/10.46531/SINAPSE/AR/210028/2021.
Howland, Kathleen M. “Music Therapy | Mental Health, Stress Relief & Well-Being.” Britannica. https://www.britannica.com/topic/music-therapy. Accessed 28 Jul. 2025.
Lee, Alyssa Wan-Chei, et al. “Emerging Therapies for Neurological Disorders: A Clinical Review of MANAGED (Music, Art, Nature-Based, Animal-Assisted, Game, Essential Oil, Dance) Care.” NeuroSci, vol. 6, no. 2, Jun. 2025, p. 51, https://doi.org/10.3390/NEUROSCI6020051.
Lin, Lung Chang, et al. “Parasympathetic Activation Is Involved in Reducing Epileptiform Discharges When Listening to Mozart Music.” Clinical Neurophysiology, vol. 124, no. 8, Aug. 2013, pp. 1528–35, https://doi.org/10.1016/J.CLINPH.2013.02.021.
Maguire, Melissa Jane. “Music and Epilepsy: A Critical Review.” Epilepsia, vol. 53, no. 6, Jun. 2012, pp. 947–61, https://doi.org/10.1111/J.1528-1167.2012.03523.X.
———. “Wired for Sound: The Effect of Sound on the Epileptic Brain.” Seizure, vol. 102, Nov. 2022, pp. 22–31, https://doi.org/10.1016/J.SEIZURE.2022.09.016.
National Institute of Neurological Disorders and Stroke. “Epilepsy and Seizures.” National Institute of Neurological Disorders and Stroke, 1 Mar. 2024, https://www.ninds.nih.gov/health-information/disorders/epilepsy-and-seizures.
Raglio, Alfredo. “Effects of Music and Music Therapy on Mood in Neurological Patients.” World Journal of Psychiatry, vol. 5, no. 1, 2015, p. 68, https://doi.org/10.5498/WJP.V5.I1.68.
Sesso, Gianluca, and Federico Sicca. “Safe and Sound: Meta-Analyzing the Mozart Effect on Epilepsy.” Clinical Neurophysiology, vol. 131, no. 7, Jul. 2020, pp. 1610–20, https://doi.org/10.1016/J.CLINPH.2020.03.039.
Valentine, David. “Epileptiform Activity on EEG.” Learning EEG. https://www.learningeeg.com/epileptiform-activity. Accessed 25 Jul. 2025.
Yang, Haitao, et al. “The Impact of Frequency-Specific Music Stimulation on Consciousness in Patients with Disorders of Consciousness.” Frontiers in Neurology, vol. 16, 2025, https://doi.org/10.3389/FNEUR.2025.1506261.
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