Childhood Adversity Impact on Brain Development and Persistence in Adulthood
Threat versus Deprivation and Therapeutic Interventions
DOI:
https://doi.org/10.58445/rars.3239Keywords:
adolescent, child adversity, threat, deprivation, adult progression, PTSD, persistent effects, structural development, functional developmentAbstract
Sixty-four percent of adults in the U.S. report having endured at least one adverse experience before the age of eighteen. In this paper, the two major sections are threat versus deprivation and the differences in functional and structural brain neurodevelopment. In the context of this research, this paper discusses the distinct differences between threat and deprivation as adverse experiences, as well as the resulting differences in structural and functional brain neurodevelopment. We also consider how adverse experiences may increase the risk of developing disorders such as post-traumatic stress disorder. The paper concludes with a brief review of potential ways to mitigate adverse outcomes by promoting a functional, healthy lifestyle early in development. Moreover, by examining numerous studies conducted in the United States, each targeting different aspects of child adversity and brain development, my research will encompass recent trends in America while also considering the statistics that often go unreported.
Keywords: adolescent, child adversity, threat, deprivation, adult progression, PTSD, persistent effects, structural development, functional development
References
Avinun, R., Nevo, A., Knodt, A. R., Elliott, M. L., Radtke, S. R., Brigidi, B. D., & Hariri, A. R. (2017). Reward-Related Ventral Striatum Activity Buffers against the Experience of Depressive Symptoms Associated with Sleep Disturbances. The Journal of Neuroscience, 37(40), 9724–9729. https://doi.org/10.1523/JNEUROSCI.1734-17.2017
Bilek E, Itz ML, Stößel G, Ma R, Berhe O, Clement L, Zang Z, Robnik L, Plichta MM, Neukel C, Schmahl C, Kirsch P, Meyer-Lindenberg A, Tost H. Deficient Amygdala Habituation to Threatening Stimuli in Borderline Personality Disorder Relates to Adverse Childhood Experiences. Biol Psychiatry. 2019 Dec 15;86(12):930-938. doi: 10.1016/j.biopsych.2019.06.008. Epub 2019 Jun 19. PMID: 31366446
Bounoua, N., Miglin, R., Spielberg, J. M., & Sadeh, N. (2020). Childhood assaultive trauma and physical aggression: Links with cortical thickness in prefrontal and occipital cortices. NeuroImage: Clinical, 27, 102321. https://doi.org/10.1016/j.nicl.2020.102321
CDC. (2025, January 31). About Child Abuse and Neglect. Child Abuse and Neglect Prevention. https://www.cdc.gov/child-abuse-neglect/about/index.html
Division (DCD), D. C. (13 C.E., February 9). What is child abuse or neglect? What is the definition of child abuse and neglect? [FAQ]. https://www.hhs.gov/answers/programs-for-families-and-children/what-is-child-abuse/index.html
Fostering Social Skills—Kids First. (n.d.). Retrieved September 21, 2025, from https://www.kidsfirstservices.com/first-insights/fostering-social-skills
Goetschius, L. G., Hein, T. C., Mitchell, C., Lopez-Duran, N. L., McLoyd, V. C., Brooks-Gunn, J., McLanahan, S. S., Hyde, L. W., & Monk, C. S. (2020). Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivity. Developmental cognitive neuroscience, 45, 100849. https://doi.org/10.1016/j.dcn.2020.100849
Hanson, J. L., Hariri, A. R., & Williamson, D. E. (2015). Blunted Ventral Striatum Development in Adolescence Reflects Emotional Neglect and Predicts Depressive Symptoms. Biological Psychiatry, 78(9), 598–605. https://doi.org/10.1016/j.biopsych.2015.05.010
Herring, R. J. (2017). Trauma, PTSD and the Developing Brain. Current Psychiatry Reports, 19(10), 69. https://doi.org/10.1007/s11920-017-0825-3
Hein, T. C., Goetschius, L. G., McLoyd, V. C., Brooks-Gunn, J., McLanahan, S. S., Mitchell, C., Lopez-Duran, N. L., Hyde, L. W., & Monk, C. S. (2020). Childhood violence exposure and social deprivation are linked to adolescent threat and reward neural function. Social Cognitive and Affective Neuroscience, 15(11), 1252-1259. https://doi.org/10.1093/scan/nsaa144
Hein, T. C., & Monk, C. S. (2016). Research Review: Neural response to threat in children, adolescents, and adults after child maltreatment – a quantitative meta‐analysis. Journal of Child Psychology and Psychiatry, 58(3), 222-230. https://doi.org/10.1111/jcpp.12651
Hill, J., Inder, T., Neil, J., Dierker, D., Harwell, J., & Van Essen, D. (2010). Similar patterns of cortical expansion during human development and evolution. Proceedings of the National Academy of Sciences of the United States of America, 107(29), 13135–13140. https://doi.org/10.1073/pnas.1001229107
Lambert, H. K., & McLaughlin, K. A. (2019). Impaired hippocampus-dependent associative learning as a mechanism underlying PTSD: A meta-analysis. Neuroscience and Biobehavioral Reviews, 107, 729–749. https://doi.org/10.1016/j.neubiorev.2019.09.024
Machlin, L., Egger, H. L., Stein, C. R., Navarro, E., Carpenter, K. L. H., Goel, S., Patel, K. K., Copeland, W. E., & Sheridan, M. A. (2023a). Distinct Associations of Deprivation and Threat With Alterations in Brain Structure in Early Childhood. Journal of the American Academy of Child and Adolescent Psychiatry, 62(8), 885-894.e3. https://doi.org/10.1016/j.jaac.2023.02.006
Machlin, L., Egger, H. L., Stein, C. R., Navarro, E., Carpenter, K. L. H., Goel, S., Patel, K. K., Copeland, W. E., & Sheridan, M. A. (2023b). Distinct Associations of Deprivation and Threat With Alterations in Brain Structure in Early Childhood. Journal of the American Academy of Child & Adolescent Psychiatry, 62(8), 885-894.e3. https://doi.org/10.1016/j.jaac.2023.02.006
Mackes, N. K., Golm, D., Sarkar, S., Kumsta, R., Rutter, M., Fairchild, G., Mehta, M. A., & Sonuga-Barke, E. J. S. (2020). Early childhood deprivation is associated with alterations in adult brain structure despite subsequent environmental enrichment. Proceedings of the National Academy of Sciences of the United States of America, 117(1), 641–649. https://doi.org/10.1073/pnas.1911264116
Marzola, P., Melzer, T., Pavesi, E., Gil-Mohapel, J., & Brocardo, P. S. (2023a). Exploring the Role of Neuroplasticity in Development, Aging, and Neurodegeneration. Brain Sciences, 13(12), 1610. https://doi.org/10.3390/brainsci13121610
Marzola, P., Melzer, T., Pavesi, E., Gil-Mohapel, J., & Brocardo, P. S. (2023b). Exploring the Role of Neuroplasticity in Development, Aging, and Neurodegeneration. Brain Sciences, 13(12), 1610. https://doi.org/10.3390/brainsci13121610
McCrory, E. J., Brito, S. A. D., Sebastian, C. L., Mechelli, A., Bird, G., Kelly, P. A., & Viding, E. (2011). Heightened neural reactivity to threat in child victims of family violence. Current Biology, 21(23), R947–R948. https://doi.org/10.1016/j.cub.2011.10.015
McLaughlin, K. A., Koenen, K. C., Bromet, E. J., Karam, E. G., Liu, H., Petukhova, M., Ruscio, A. M., Sampson, N. A., Stein, D. J., Aguilar-Gaxiola, S., Alonso, J., Borges, G., Demyttenaere, K., Dinolova, R. V., Ferry, F., Florescu, S., de Girolamo, G., Gureje, O., Kawakami, N., … Kessler, R. C. (2017). Childhood adversities and post-traumatic stress disorder: Evidence for stress sensitisation in the World Mental Health Surveys. The British Journal of Psychiatry, 211(5), 280–288. https://doi.org/10.1192/bjp.bp.116.197640
McLaughlin, K. A., & Lambert, H. K. (2017a). Child Trauma Exposure and Psychopathology: Mechanisms of Risk and Resilience. Current Opinion in Psychology, 14, 29–34. https://doi.org/10.1016/j.copsyc.2016.10.004
McLaughlin, K. A., & Lambert, H. K. (2017b). Child Trauma Exposure and Psychopathology: Mechanisms of Risk and Resilience. Current Opinion in Psychology, 14, 29–34. https://doi.org/10.1016/j.copsyc.2016.10.004
McLaughlin, K. A., Sheridan, M. A., & Lambert, H. K. (2014a). Childhood Adversity and Neural Development: Deprivation and Threat as Distinct Dimensions of Early Experience. Neuroscience and Biobehavioral Reviews, 47, 578–591. https://doi.org/10.1016/j.neubiorev.2014.10.012
McLaughlin, K. A., Sheridan, M. A., & Lambert, H. K. (2014b). Childhood Adversity and Neural Development: Deprivation and Threat as Distinct Dimensions of Early Experience. Neuroscience and Biobehavioral Reviews, 47, 578–591. https://doi.org/10.1016/j.neubiorev.2014.10.012
O’Donovan, A., Slavich, G. M., Epel, E. S., & Neylan, T. C. (2013). Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of aging. Neuroscience and Biobehavioral Reviews, 37(1), 96–108. https://doi.org/10.1016/j.neubiorev.2012.10.013
Orben, A., Tomova, L., & Blakemore, S.-J. (2020). The effects of social deprivation on adolescent development and mental health. The Lancet. Child & Adolescent Health, 4(8), 634–640. https://doi.org/10.1016/S2352-4642(20)30186-3
Petersen, A. C., Joseph, J., Feit, M., Committee on Child Maltreatment Research, P., Board on Children, Y., Justice, C. on L. and, Medicine, I. of, & Council, N. R. (2014). Consequences of Child Abuse and Neglect. In New Directions in Child Abuse and Neglect Research. National Academies Press (US). https://www.ncbi.nlm.nih.gov/books/NBK195987/
Physical Activity and Cognitive Functioning of Children: A Systematic Review—PMC. (n.d.). Retrieved October 1, 2025, from https://pmc.ncbi.nlm.nih.gov/articles/PMC5923842/
Roberts, M., Tolar-Peterson, T., Reynolds, A., Wall, C., Reeder, N., & Rico Mendez, G. (2022). The Effects of Nutritional Interventions on the Cognitive Development of Preschool-Age Children: A Systematic Review. Nutrients, 14(3), 532. https://doi.org/10.3390/nu14030532
Sheridan, M. A., Mukerji, C. E., Wade, M., Humphreys, K. L., Garrisi, K., Goel, S., Patel, K., Fox, N. A., Zeanah, C. H., Nelson, C. A., & McLaughlin, K. A. (2022). Early deprivation alters structural brain development from middle childhood to adolescence. Science Advances, 8(40), eabn4316. https://doi.org/10.1126/sciadv.abn4316
Starcevic, A., Postic, S., Radojicic, Z., Starcevic, B., Milovanovic, S., Ilankovic, A., Dimitrijevic, I., Damjanovic, A., Aksić, M., & Radonjic, V. (2014). Volumetric Analysis of Amygdala, Hippocampus, and Prefrontal Cortex in Therapy-Naive PTSD Participants. BioMed Research International, 2014, 968495. https://doi.org/10.1155/2014/968495
Stensvehagen, M. T., Bronken, B. A., Lien, L., & Larsson, G. (2022). Interrelationship of Posttraumatic Stress, Hassles, Uplifts, and Coping in Women With a History of Severe Sexual Abuse: A Cross-Sectional Study. Journal of Interpersonal Violence, 37(5–6), 2289–2309. https://doi.org/10.1177/0886260520935479
To Improve Your Kid’s Mood, Make Them Move. (n.d.). Retrieved October 1, 2025, from https://www.childrenscolorado.org/just-ask-childrens/articles/mental-health-benefits-exercise/
van den Bulk, B. G., Meens, P. H. F., van Lang, N. D. J., de Voogd, E. L., van der Wee, N. J. A., Rombouts, S. A. R. B., Crone, E. A., & Vermeiren, R. R. J. M. (2014). Amygdala activation during emotional face processing in adolescents with affective disorders: The role of underlying depression and anxiety symptoms. Frontiers in Human Neuroscience, 8, 393. https://doi.org/10.3389/fnhum.2014.00393
Verduyn, P., & Brans, K. (2012). The relationship between extraversion, neuroticism and aspects of trait affect. Personality and Individual Differences, 52(6), 664–669. https://doi.org/10.1016/j.paid.2011.12.017
Yang, F. N., Xie, W., & Wang, Z. (2022). Effects of sleep duration on neurocognitive development in U.S. early adolescents: A propensity score matched, longitudinal, observational study. The Lancet. Child & Adolescent Health, S2352-4642(22)00188-2. https://doi.org/10.1016/S2352-4642(22)00188-2
Zimmermann, K. S., Richardson, R., & Baker, K. D. (2023). Developmental changes in functional connectivity between the prefrontal cortex and amygdala following fear extinction. Neurobiology of Learning and Memory, 205, 107847. https://doi.org/10.1016/j.nlm.2023.107847
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