Wired and Tired: Sleep Science from Neurobiology to Daily Struggles
DOI:
https://doi.org/10.58445/rars.2829Keywords:
Sleep Science, Neurobiology, Circadian RhythmsAbstract
Sleep is a complex biological process regulated by neural systems, circadian rhythms, environmental cues and more. Poor sleep quality has become a global public health concern, affecting nearly one-third of adults worldwide. This paper provides an overview of sleep biology, the causes of poor sleep, and its consequences for mental and physiological health. It outlines the structure and regulation of healthy sleep, followed by biological, behavioral, environmental, and genetic disruptions that can worsen sleep quality. It then examines common clinical sleep disorders - such as obstructive sleep apnea, insomnia, narcolepsy, hypersomnolence disorder and REM sleep behavior disorder - and reviews current medications. This paper aims to provide an interdisciplinary overview of sleep biology, explore the complex causes of poor sleep, and examine how its disruption affects nearly every aspect of human functioning.
References
Abel, J. H., Widmer, L. A., John, P. C. S., Stelling, J., & III, F. J. D. (2015). A Coupled Stochastic Model Explains Differences in Circadian Behavior of Cry1 and Cry2 Knockouts (No. arXiv:1411.4624). arXiv. https://doi.org/10.48550/arXiv.1411.4624
Alkhaldi, E. H., Battar, S., Alsuwailem, S. I., Almutairi, K. S., Alshamari, W. K., & Alkhaldi, A. H. (n.d.). Effect of Nighttime Exercise on Sleep Quality Among the General Population in Riyadh, Saudi Arabia: A Cross-Sectional Study. Cureus, 15(7), e41638. https://doi.org/10.7759/cureus.41638
Basner, M., & Dinges, D. F. (2011). Maximizing sensitivity of the psychomotor vigilance test (PVT) to sleep loss. Sleep, 34(5), 581–591. https://doi.org/10.1093/sleep/34.5.581
Basner, M., Hermosillo, E., Nasrini, J., McGuire, S., Saxena, S., Moore, T. M., Gur, R. C., & Dinges, D. F. (2018). Repeated Administration Effects on Psychomotor Vigilance Test Performance. Sleep, 41(1). https://doi.org/10.1093/sleep/zsx187
Basner, M., Mollicone, D., & Dinges, D. F. (2011). Validity and Sensitivity of a Brief Psychomotor Vigilance Test (PVT-B) to Total and Partial Sleep Deprivation. Acta Astronautica, 69(11–12), 949–959. https://doi.org/10.1016/j.actaastro.2011.07.015
Benjafield, A. V., Ayas, N. T., Eastwood, P. R., Heinzer, R., Ip, M. S. M., Morrell, M. J., Nunez, C. M., Patel, S. R., Penzel, T., Pépin, J.-L., Peppard, P. E., Sinha, S., Tufik, S., Valentine, K., & Malhotra, A. (2019). Estimation of the global prevalence and burden of obstructive sleep apnoea: A literature-based analysis. The Lancet. Respiratory Medicine, 7(8), 687–698. https://doi.org/10.1016/S2213-2600(19)30198-5
Buckley, T. M., & Schatzberg, A. F. (2005). On the interactions of the hypothalamic-pituitary-adrenal (HPA) axis and sleep: Normal HPA axis activity and circadian rhythm, exemplary sleep disorders. The Journal of Clinical Endocrinology and Metabolism, 90(5), 3106–3114. https://doi.org/10.1210/jc.2004-1056
Chen, H., Xing, Y., Wan, C., Zhang, Z., Shi, Z., Liang, Y., Jin, C., Chen, Y., Zhou, X., Xu, J., Ptáček, L. J., Fu, Y.-H., & Shi, G. (2025). The SIK3-N783Y mutation is associated with the human natural short sleep trait. Proceedings of the National Academy of Sciences, 122(19), e2500356122. https://doi.org/10.1073/pnas.2500356122
Chu, B., Marwaha, K., Sanvictores, T., Awosika, A. O., & Ayers, D. (2025). Physiology, Stress Reaction. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK541120/
Çiçek, İ., & Yıldırım, M. (2025). Exploring the impact of family conflict on depression, anxiety and sleep problems in Turkish adolescents: The mediating effect of social connectedness. Journal of Psychologists and Counsellors in Schools, 35(2), 130–146. https://doi.org/10.1177/20556365251331108
Cuellar, N. G., Whisenant, D., & Stanton, M. P. (2015). Hypnic Jerks: A Scoping Literature Review. Sleep Medicine Clinics, 10(3), 393–401, xvi. https://doi.org/10.1016/j.jsmc.2015.05.010
Demichelis, O. P., Grainger, S. A., Burr, L., & Henry, J. D. (2023). Emotion regulation mediates the effects of sleep on stress and aggression. Journal of Sleep Research, 32(3), e13787. https://doi.org/10.1111/jsr.13787
Di Muzio, M., Diella, G., Di Simone, E., Novelli, L., Alfonsi, V., Scarpelli, S., Annarumma, L., Salfi, F., Pazzaglia, M., Giannini, A. M., & De Gennaro, L. (2020). Nurses and Night Shifts: Poor Sleep Quality Exacerbates Psychomotor Performance. Frontiers in Neuroscience, 14, 579938. https://doi.org/10.3389/fnins.2020.579938
Fernandez, L. M. J., & Lüthi, A. (2020). Sleep Spindles: Mechanisms and Functions. Physiological Reviews, 100(2), 805–868. https://doi.org/10.1152/physrev.00042.2018
Frank, S., Gonzalez, K., Lee-Ang, L., Young, M. C., Tamez, M., & Mattei, J. (2017). Diet and Sleep Physiology: Public Health and Clinical Implications. Frontiers in Neurology, 8, 393. https://doi.org/10.3389/fneur.2017.00393
Gallagher, C., Austin, V., Dunlop, K. A., Dally, J., Taylor, K., Pullinger, S. A., & Edwards, B. J. (2024). Effects of Supplementing Zinc Magnesium Aspartate on Sleep Quality and Submaximal Weightlifting Performance, following Two Consecutive Nights of Partial Sleep Deprivation. Nutrients, 16(2), 251. https://doi.org/10.3390/nu16020251
Hansen, D. A., Layton, M. E., Riedy, S. M., & Van Dongen, H. P. (2019). Psychomotor Vigilance Impairment During Total Sleep Deprivation Is Exacerbated in Sleep-Onset Insomnia. Nature and Science of Sleep, 11, 401–410. https://doi.org/10.2147/NSS.S224641
Idiopathic Hypersomnia: Recognition and Management in Psychiatric Practice. (n.d.). Psychiatrist.Com. Retrieved July 20, 2025, from https://www.psychiatrist.com/jcp/idiopathic-hypersomnia-recognition-management-in-psychiatric-practice/
Iranzo, A., Molinuevo, J. L., Santamaría, J., Serradell, M., Martí, M. J., Valldeoriola, F., & Tolosa, E. (2006). Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: A descriptive study. The Lancet. Neurology, 5(7), 572–577. https://doi.org/10.1016/S1474-4422(06)70476-8
Iranzo, A., Santamaria, J., & Tolosa, E. (2009). The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseases. Sleep Medicine Reviews, 13(6), 385–401. https://doi.org/10.1016/j.smrv.2008.11.003
Kelly, R. J., Thompson, M. J., & El-Sheikh, M. (2024). Exposure to parental interpartner conflict in adolescence predicts sleep problems in emerging adulthood. Sleep Health: Journal of the National Sleep Foundation, 10(5), 576–582. https://doi.org/10.1016/j.sleh.2024.06.003
Killgore, W. D. S. (2010). Effects of sleep deprivation on cognition. Progress in Brain Research, 185, 105–129. https://doi.org/10.1016/B978-0-444-53702-7.00007-5
Krause, A. J., Simon, E. B., Mander, B. A., Greer, S. M., Saletin, J. M., Goldstein-Piekarski, A. N., & Walker, M. P. (2017). The sleep-deprived human brain. Nature Reviews Neuroscience, 18(7), 404–418. https://doi.org/10.1038/nrn.2017.55
Kredlow, M. A., Capozzoli, M. C., Hearon, B. A., Calkins, A. W., & Otto, M. W. (2015). The effects of physical activity on sleep: A meta-analytic review. Journal of Behavioral Medicine, 38(3), 427–449. https://doi.org/10.1007/s10865-015-9617-6
Langille, J. J. (2019). Remembering to Forget: A Dual Role for Sleep Oscillations in Memory Consolidation and Forgetting. Frontiers in Cellular Neuroscience, 13. https://doi.org/10.3389/fncel.2019.00071
Lin, Q.-C., Zhang, X.-B., Chen, G.-P., Huang, D.-Y., Din, H.-B., & Tang, A.-Z. (2012). Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome in nonobese adults. Sleep & Breathing = Schlaf & Atmung, 16(2), 571–578. https://doi.org/10.1007/s11325-011-0544-7
Liu, J., Ghastine, L., Um, P., Rovit, E., & Wu, T. (2021). Environmental exposures and sleep outcomes: A review of evidence, potential mechanisms, and implications. Environmental Research, 196, 110406. https://doi.org/10.1016/j.envres.2020.110406
Mahlios, J., De la Herrán-Arita, A. K., & Mignot, E. (2013). The Autoimmune Basis of Narcolepsy. Current Opinion in Neurobiology, 23(5), 10.1016/j.conb.2013.04.013. https://doi.org/10.1016/j.conb.2013.04.013
Mahoney, C. E., Cogswell, A., Koralnik, I. J., & Scammell, T. E. (2019). The neurobiological basis of narcolepsy. Nature Reviews. Neuroscience, 20(2), 83–93. https://doi.org/10.1038/s41583-018-0097-x
Matsangas, P., & Shattuck, N. L. (2020). Sleep quality, occupational factors, and psychomotor vigilance performance in the U.S. Navy sailors. Sleep, 43(12), zsaa118. https://doi.org/10.1093/sleep/zsaa118
Mbiydzenyuy, N. E., & Qulu, L.-A. (2024). Stress, hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, and aggression. Metabolic Brain Disease, 39(8), 1613–1636. https://doi.org/10.1007/s11011-024-01393-w
Mirabile, V. S., & Sharma, S. (2025). Cataplexy. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK549782/
Mitra, A., Snyder, A. Z., Hacker, C. D., Pahwa, M., Tagliazucchi, E., Laufs, H., Leuthardt, E. C., & Raichle, M. E. (2016). Human cortical–hippocampal dialogue in wake and slow-wave sleep. Proceedings of the National Academy of Sciences, 113(44), E6868–E6876. https://doi.org/10.1073/pnas.1607289113
Moore, R. Y. (2007). Suprachiasmatic nucleus in sleep-wake regulation. Sleep Medicine, 8 Suppl 3, 27–33. https://doi.org/10.1016/j.sleep.2007.10.003
Münch, M., Kobialka, S., Steiner, R., Oelhafen, P., Wirz-Justice, A., & Cajochen, C. (2006). Wavelength-dependent effects of evening light exposure on sleep architecture and sleep EEG power density in men. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 290(5), R1421–R1428. https://doi.org/10.1152/ajpregu.00478.2005
Murray, J. M., Phillips, A. J. K., Magee, M., Sletten, T. L., Gordon, C., Lovato, N., Bei, B., Bartlett, D. J., Kennaway, D. J., Lack, L. C., Grunstein, R. R., Lockley, S. W., Rajaratnam, S. M. W., Armstrong, E., Chohan, K., Djavadkhani, Y., Dodds, K., Gunaratnam, S., Hardy, M., … Yu, K. (2019). Sleep regularity is associated with sleep-wake and circadian timing, and mediates daytime function in Delayed Sleep-Wake Phase Disorder. Sleep Medicine, 58, 93–101. https://doi.org/10.1016/j.sleep.2019.03.009
Okun, M. L. (2011). Biological Consequences of Disturbed Sleep: Important Mediators of Health? The Japanese Psychological Research, 53(2), 163–176. https://doi.org/10.1111/j.1468-5884.2011.00463.x
Ostrin, L. A., Abbott, K. S., & Queener, H. M. (2017). Attenuation of short wavelengths alters sleep and the ipRGC pupil response. Ophthalmic & Physiological Optics : The Journal of the British College of Ophthalmic Opticians (Optometrists), 37(4), 440–450. https://doi.org/10.1111/opo.12385
Park, I., Díaz, J., Matsumoto, S., Iwayama, K., Nabekura, Y., Ogata, H., Kayaba, M., Aoyagi, A., Yajima, K., Satoh, M., Tokuyama, K., & Vogt, K. E. (2021). Exercise improves the quality of slow-wave sleep by increasing slow-wave stability. Scientific Reports, 11(1), 4410. https://doi.org/10.1038/s41598-021-83817-6
Patan, M. J., Kennedy, D. O., Husberg, C., Hustvedt, S. O., Calder, P. C., Middleton, B., Khan, J., Forster, J., & Jackson, P. A. (2021). Differential Effects of DHA- and EPA-Rich Oils on Sleep in Healthy Young Adults: A Randomized Controlled Trial. Nutrients, 13(1), 248. https://doi.org/10.3390/nu13010248
Peppard, P. E., Young, T., Palta, M., Dempsey, J., & Skatrud, J. (2000). Longitudinal Study of Moderate Weight Change and Sleep-Disordered Breathing. JAMA, 284(23), 3015–3021. https://doi.org/10.1001/jama.284.23.3015
Postuma, R. B., Bertrand, J.-A., Montplaisir, J., Desjardins, C., Vendette, M., Rios Romenets, S., Panisset, M., & Gagnon, J.-F. (2012). Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson’s disease: A prospective study. Movement Disorders: Official Journal of the Movement Disorder Society, 27(6), 720–726. https://doi.org/10.1002/mds.24939
Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., & Nissen, C. (2010a). The hyperarousal model of insomnia: A review of the concept and its evidence. Sleep Medicine Reviews, 14(1), 19–31. https://doi.org/10.1016/j.smrv.2009.04.002
Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., & Nissen, C. (2010b). The hyperarousal model of insomnia: A review of the concept and its evidence. Sleep Medicine Reviews, 14(1), 19–31. https://doi.org/10.1016/j.smrv.2009.04.002
Roenneberg, T., & Merrow, M. (2016). The Circadian Clock and Human Health. Current Biology: CB, 26(10), R432-443. https://doi.org/10.1016/j.cub.2016.04.011
Rye, D. B., Bliwise, D. L., Parker, K., Trotti, L. M., Saini, P., Fairley, J., Freeman, A., Garcia, P. S., Owens, M. J., Ritchie, J. C., & Jenkins, A. (2012). Modulation of vigilance in the primary hypersomnias by endogenous enhancement of GABAA receptors. Science Translational Medicine, 4(161), 161ra151. https://doi.org/10.1126/scitranslmed.3004685
Scammell, T. E. (2015). Narcolepsy. New England Journal of Medicine, 373(27), 2654–2662. https://doi.org/10.1056/NEJMra1500587
Schwartz, A. R., Patil, S. P., Laffan, A. M., Polotsky, V., Schneider, H., & Smith, P. L. (2008). Obesity and Obstructive Sleep Apnea. Proceedings of the American Thoracic Society, 5(2), 185–192. https://doi.org/10.1513/pats.200708-137MG
Schwartz, M. D., & Kilduff, T. S. (2015). The Neurobiology of Sleep and Wakefulness. The Psychiatric Clinics of North America, 38(4), 615–644. https://doi.org/10.1016/j.psc.2015.07.002
Scott, H., Naik, G., Lechat, B., Manners, J., Fitton, J., Nguyen, D. P., Hudson, A. L., Reynolds, A. C., Sweetman, A., Escourrou, P., Catcheside, P., & Eckert, D. J. (2024a). Are we getting enough sleep? Frequent irregular sleep found in an analysis of over 11 million nights of objective in-home sleep data. Sleep Health: Journal of the National Sleep Foundation, 10(1), 91–97. https://doi.org/10.1016/j.sleh.2023.10.016
Scott, H., Naik, G., Lechat, B., Manners, J., Fitton, J., Nguyen, D. P., Hudson, A. L., Reynolds, A. C., Sweetman, A., Escourrou, P., Catcheside, P., & Eckert, D. J. (2024b). Are we getting enough sleep? Frequent irregular sleep found in an analysis of over 11 million nights of objective in-home sleep data. Sleep Health: Journal of the National Sleep Foundation, 10(1), 91–97. https://doi.org/10.1016/j.sleh.2023.10.016
Sell, N. T., Sisson, N. M., Gordon, A. M., Stanton, S. C. E., & Impett, E. A. (2023). Daily Sleep Quality and Support in Romantic Relationships: The Role of Negative Affect and Perspective-Taking. Affective Science, 4(2), 370–384. https://doi.org/10.1007/s42761-023-00180-7
Shahar, E., Whitney, C. W., Redline, S., Lee, E. T., Newman, A. B., Nieto, F. J., O’Connor, G. T., Boland, L. L., Schwartz, J. E., & Samet, J. M. (2001). Sleep-disordered breathing and cardiovascular disease: Cross-sectional results of the Sleep Heart Health Study. American Journal of Respiratory and Critical Care Medicine, 163(1), 19–25. https://doi.org/10.1164/ajrccm.163.1.2001008
Shao, Y., Lei, Y., Wang, L., Zhai, T., Jin, X., Ni, W., Yang, Y., Tan, S., Wen, B., Ye, E., & Yang, Z. (2014). Altered resting-state amygdala functional connectivity after 36 hours of total sleep deprivation. PloS One, 9(11), e112222. https://doi.org/10.1371/journal.pone.0112222
Singh, A. K., Mahlios, J., & Mignot, E. (2013). Genetic association, seasonal infections and autoimmune basis of narcolepsy. Journal of Autoimmunity, 43, 26–31. https://doi.org/10.1016/j.jaut.2013.02.003
Surawicz, B., & Knilans, T. K. (Eds.). (2008). Chapter 20—Ventricular Preexcitation (Wolff-Parkinson-White Syndrome and Its Variants). In Chou’s Electrocardiography in Clinical Practice (Sixth Edition) (pp. 481–508). W.B. Saunders. https://doi.org/10.1016/B978-141603774-3.10020-6
Thorpy, M. J., Krahn, L., Ruoff, C., & Foldvary-Schaefer, N. (2024). Clinical considerations in the treatment of idiopathic hypersomnia. Sleep Medicine, 119, 488–498. https://doi.org/10.1016/j.sleep.2024.05.013
Trotti, L. M. (2017). Idiopathic Hypersomnia. Sleep Medicine Clinics, 12(3), 331–344. https://doi.org/10.1016/j.jsmc.2017.03.009
Vgontzas, A. N., Bixler, E. O., Lin, H. M., Prolo, P., Mastorakos, G., Vela-Bueno, A., Kales, A., & Chrousos, G. P. (2001). Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: Clinical implications. The Journal of Clinical Endocrinology and Metabolism, 86(8), 3787–3794. https://doi.org/10.1210/jcem.86.8.7778
Walker, M. P. (2009). The Role of Slow Wave Sleep in Memory Processing. Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine, 5(2 Suppl), S20–S26.
Wang, Y.-Q., Liu, W.-Y., Li, L., Qu, W.-M., & Huang, Z.-L. (2021). Neural circuitry underlying REM sleep: A review of the literature and current concepts. Progress in Neurobiology, 204, 102106. https://doi.org/10.1016/j.pneurobio.2021.102106
West, K. E., Jablonski, M. R., Warfield, B., Cecil, K. S., James, M., Ayers, M. A., Maida, J., Bowen, C., Sliney, D. H., Rollag, M. D., Hanifin, J. P., & Brainard, G. C. (2011). Blue light from light-emitting diodes elicits a dose-dependent suppression of melatonin in humans. Journal of Applied Physiology (Bethesda, Md.: 1985), 110(3), 619–626. https://doi.org/10.1152/japplphysiol.01413.2009
Wolk, R., Shamsuzzaman, A. S. M., & Somers, V. K. (2003). Obesity, Sleep Apnea, and Hypertension. Hypertension, 42(6), 1067–1074. https://doi.org/10.1161/01.HYP.0000101686.98973.A3
Yoo, S.-S., Hu, P. T., Gujar, N., Jolesz, F. A., & Walker, M. P. (2007). A deficit in the ability to form new human memories without sleep. Nature Neuroscience, 10(3), 385–392. https://doi.org/10.1038/nn1851
Downloads
Posted
Categories
License
Copyright (c) 2025 Madina Ilzhanova

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.