Visualizing Dementia’s Impact
Analyzing MRI Scans to Identify Key Brain Regions through Python-Based Image Comparison
DOI:
https://doi.org/10.58445/rars.1953Keywords:
Machine learning, neuroscience, dementia, brain, alzheimer's diseaseAbstract
MRI scans of dementia patients were analyzed to identify commonalities and differences in specific areas when compared to non-demented patients. Using Python, average images of the brain scans for both groups were created, and the differences were plotted to visually highlight regions of significant variation. This approach identified critical areas affected by dementia, such as the hippocampus and ventricles, which display distinct patterns of atrophy and enlargement, consistent with previous studies. By generating these comparative images, this analysis aimed to enhance understanding of how dementia structurally impacts the brain, providing a visual representation that can aid in more accurate diagnosis and assessment of the disease's progression. These visual insights contribute to the broader goal of utilizing computational methods to pinpoint early indicators of dementia, offering potential pathways for future AI models to further refine the detection and prediction of this condition.
References
Alzheimer's Association. (2023). Alzheimer's Disease Facts and Figures. Alzheimer's & Dementia, 19(1), 159-229. Retrieved from Alzheimer's Association.
Jack, C. R., et al. (2018). NIA-AA Research Framework: Toward a Biological Definition of Alzheimer’s Disease. Alzheimer's & Dementia, 14(4), 535-562.
McKhann, G. M., et al. (2011). The Diagnosis of Dementia Due to Alzheimer’s Disease: Recommendations from the National Institute on Aging and the Alzheimer’s Association Workgroups. Alzheimer's & Dementia, 7(3), 263-269.
Mosconi, L., et al. (2010). Role of PET and MRI Imaging in Predicting Alzheimer’s Disease. Neurobiology of Aging, 31(1), 17-24.
Blennow, K., et al. (2015). Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease. Nature Reviews Neurology, 11(2), 103-118.
Cummings, J., et al. (2019). Early Intervention in Alzheimer’s Disease: Evidence and Implications for Clinical Practice. Therapeutic Advances in Neurological Disorders, 12, 1-12.
Brodaty, H., & Donkin, M. (2009). Family Caregivers of People with Dementia. Dialogues in Clinical Neuroscience, 11(2), 217-228.
Hampel, H., et al. (2018). The Future of Alzheimer’s Disease Biomarkers in Clinical Trials. Journal of Alzheimer’s Disease, 62(3), 1217-1231.
Goodfellow, I., Bengio, Y., & Courville, A. (2016). Deep Learning. MIT Press.
LeCun, Y., Bengio, Y., & Hinton, G. (2015). Deep Learning. Nature, 521(7553), 436-444.
Nair, V., & Hinton, G. E. (2010). Rectified Linear Units Improve Restricted Boltzmann Machines. Proceedings of the 27th International Conference on Machine Learning (ICML-10), 807-814.
Daniel S. Marcus, Tracy H. Wang, Jamie Parker, John G. Csernansky, John C. Morris, Randy L. Buckner; Open Access Series of Imaging Studies (OASIS): Cross-sectional MRI Data in Young, Middle Aged, Nondemented, and Demented Older Adults. J Cogn Neurosci2007; 19 (9): 1498–1507. doi: https://doi.org/10.1162/jocn.2007.19.9.1498
Boysen, J. (n.d.). MRI and Alzheimers Magnetic Resonance Imaging Comparisons of Demented and Nondemented Adults. Retrieved July 2024, from https://www.kaggle.com/datasets/jboysen/mri-and-alzheimers/data.
Acknowledgements
Data was provided by Oasis: OASIS-1: Cross-Sectional: Principal Investigators: D. Marcus, R, Buckner, J, Csernansky J. Morris; P50 AG05681, P01 AG03991, P01 AG026276, R01 AG021910, P20 MH071616, U24 RR021382
Daniel S. Marcus, Tracy H. Wang, Jamie Parker, John G. Csernansky, John C. Morris, Randy L. Buckner; Open Access Series of Imaging Studies (OASIS): Cross-sectional MRI Data in Young, Middle Aged, Nondemented, and Demented Older Adults. J Cogn Neurosci2007; 19 (9): 1498–1507. doi: https://doi.org/10.1162/jocn.2007.19.9.1498
Posted
Categories
License
Copyright (c) 2024 Aditya Kudaravalli
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.